P2rx4 - purinergic receptor P2X 4 Gene

Rattus norvegicus

Gene ID: 29659 | Gene type: protein coding

About P2rx4

Primary_assembly 12: 33,844,396-33,862,253 reverse strand.mRatBN7.2:CM026985.1

This gene has 4 transcripts (splice variants), 211 orthologues, 6 paralogues and is associated with 5 phenotypes. Biased expression in Spleen (RPKM 179.), Kidney (RPKM 171.7) and 9 other tissues.

Summary

Enables several functions, including ATP binding activity; ligand-gated cation channel activity; and transition metal ion binding activity. Involved in several processes, including cellular response to zinc ion; neuronal action potential; and positive regulation of microglial cell migration. Located in several cellular components, including dendritic spine; neuronal cell body; and postsynaptic density. Is integral component of plasma membrane. Biomarker of congestive heart failure. Orthologous to human P2RX4 (purinergic receptor P2X 4). [provided by Alliance of Genome Resources, Apr 2022]

P2rx4 Products(1)

mRNA	Protein	Name
NM_031594.2	NP_113782.2	P2X purinoceptor 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	12819199	RGD
enables ATP-gated ion channel activity	IDA IDA: Inferred from direct assay	24817123	RGD
enables copper ion binding	IDA IDA: Inferred from direct assay	12819199	RGD
enables extracellularly ATP-gated monoatomic cation channel activity	IDA IDA: Inferred from direct assay	8551329	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	15313628	RGD
enables ligand-gated calcium channel activity	IMP IMP: Inferred from mutant phenotype	17299767	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	24815693	RGD
enables purinergic nucleotide receptor activity	IDA IDA: Inferred from direct assay	12819199	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	17785580	RGD
enables zinc ion binding	IDA IDA: Inferred from direct assay	12819199	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in behavioral response to pain	IMP IMP: Inferred from mutant phenotype	12917686	RGD
involved in calcium ion transmembrane transport	IDA IDA: Inferred from direct assay	8551329	RGD
involved in cellular response to ATP	IDA IDA: Inferred from direct assay	8551329	RGD
involved in cellular response to zinc ion	IDA IDA: Inferred from direct assay	8551329	RGD
involved in inorganic cation transmembrane transport	IDA IDA: Inferred from direct assay	16282518	RGD
involved in neuronal action potential	IDA IDA: Inferred from direct assay	12819199	RGD
involved in positive regulation of microglial cell migration	IMP IMP: Inferred from mutant phenotype	17299767	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	17299767	RGD
involved in regulation of chemotaxis	IMP IMP: Inferred from mutant phenotype	17299767	RGD
NOT involved in regulation of ruffle assembly	IMP IMP: Inferred from mutant phenotype	17299767	RGD
involved in regulation of sodium ion transport	IDA IDA: Inferred from direct assay	17785580	RGD
involved in response to axon injury	IMP IMP: Inferred from mutant phenotype	12917686	RGD
involved in response to ischemia	IMP IMP: Inferred from mutant phenotype	12849743	RGD
involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	12917686	RGD
involved in sensory perception of touch	IMP IMP: Inferred from mutant phenotype	12917686	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	15476696	RGD
located in cell body	IDA IDA: Inferred from direct assay	12849743	RGD
located in dendrite	IDA IDA: Inferred from direct assay	15476696	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	11160443	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	11160443	RGD
located in lysosomal membrane	IDA IDA: Inferred from direct assay	24817123	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	11160443	RGD
is active in parallel fiber to Purkinje cell synapse	IDA IDA: Inferred from direct assay	11160443	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	17785580	RGD
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	8551329	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	11160443	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	15476696	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2rx4 Protein Structure

P2X_receptor

0
100
200
300
388 a.a.

Protein Preferred Names

Protein Names

P2X purinoceptor 4

ATP receptor	P2X4
purinergic receptor P2X, ligand-gated ion channel 4

P2rx4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	P2rx4	P51577	P2rx2	Rattus norvegicus	P49653	Anti Tag CoIP	24815693
Intra	P2rx4	P51577	P2rx4	Rattus norvegicus	P51577	Comig Non-Denat Gel	19419241
Intra	P2rx4	P51577	P2rx6	Rattus norvegicus	P51579	IF	24815693
Intra	P2rx4	P51577	P2rx6	Rattus norvegicus	P51579	Anti Tag CoIP	24815693
Intra	P2rx4	P51577	P2rx4	Rattus norvegicus	P51577	AFM	19419241

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09906	P2RX4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09907	P2rx4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09908	P2rx4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	P2rx4	NCBI	NCBI:5025

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