2. Gene
  3. Acr - acrosin prepropeptide Gene

Acr - acrosin prepropeptide Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 11434 | Gene type: protein coding

About Acr

Summary

Enables peptidase activity. Involved in single fertilization. Acts upstream of or within binding activity of sperm to zona pellucida and penetration of zona pellucida. Located in acrosomal vesicle. Is expressed in testis. Orthologous to human ACR (acrosin). [provided by Alliance of Genome Resources, Apr 2022]

Acr Products(7)

mRNA Protein Name
NM_001205049.2 NP_001191978.1 acrosin isoform 2 precursor
NM_001277245.2 NP_001264174.1 acrosin isoform 3
NM_001277246.2 NP_001264175.1 acrosin isoform 3
NM_001277247.2 NP_001264176.1 acrosin isoform 4 precursor
NM_001411168.1 NP_001398097.1 acrosin isoform 5 precursor
NM_001411169.1 NP_001398098.1 acrosin isoform 3
NM_013455.4 NP_038483.1 acrosin isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables peptidase activity IMP
IMP: Inferred from mutant phenotype
7989357 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11739644 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within binding of sperm to zona pellucida IGI
IGI: Inferred from genetic interaction
15685642 MGI
acts upstream of or within penetration of zona pellucida IGI
IGI: Inferred from genetic interaction
15051954 MGI
acts upstream of or within penetration of zona pellucida IMP
IMP: Inferred from mutant phenotype
7989357 MGI
involved in single fertilization IMP
IMP: Inferred from mutant phenotype
15685642 MGI
Cellular Component GO Annotation Evidence Reference Source
located in acrosomal vesicle IDA
IDA: Inferred from direct assay
7798216 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

acrosin

preproacrosin

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-10684 Pridopidine Antagonist 99.85% Phase 3
HY-19845 Ordopidine Antagonist / Phase 1
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-129126 NC9 Inhibitor / Unkown
HY-RS00193 ACR Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-111210 Pridopidine hydrochloride Antagonist / Unkown
HY-19845A Ordopidine hydrochloride Modulator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acr NCBI NCBI:49
Canis familiaris Acr NCBI NCBI:606765
Macaca fascicularis Acr NCBI NCBI:102115325
Rattus norvegicus Acr NCBI NCBI:24163
Macaca mulatta Acr NCBI NCBI:716579