Adam10 - a disintegrin and metallopeptidase domain 10 Gene

Mus musculus

Also known as kuz; MADM; kuzbanian; 1700031C13Rik

Gene ID: 11487 | Gene type: protein coding

About Adam10

Chromosome 9: 70,586,279-70,687,511 forward strand.GRCm39:CM001002.3

This gene has 4 transcripts (splice variants), 371 orthologues, 35 paralogues and is associated with 16 phenotypes. Ubiquitous expression in liver E14 (RPKM 28.), liver E14.5 (RPKM 23.2) and 27 other tissues.

Summary

This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature Enzyme that is involved in the proteolytic release of membrane-bound proteins in a process called ectodomain shedding. Mice lacking the encoded protein die in utero with multiple defects of the developing central nervous system, somites, and cardiovascular system. [provided by RefSeq, May 2016]

Adam10 Products(1)

mRNA	Protein	Name
NM_007399.4	NP_031425.2	disintegrin and metalloproteinase domain-containing protein 10 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables endopeptidase activity	IDA IDA: Inferred from direct assay	12794186	MGI
enables endopeptidase activity	IMP IMP: Inferred from mutant phenotype	29325091	MGI
enables metallodipeptidase activity	IMP IMP: Inferred from mutant phenotype	14993236	MGI
enables metallopeptidase activity	IDA IDA: Inferred from direct assay	14761956	MGI
enables metallopeptidase activity	IMP IMP: Inferred from mutant phenotype	12354787	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12176995	MGI
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	12176995	MGI
enables protein kinase binding	IDA IDA: Inferred from direct assay	12176995	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	12354787	MGI
involved in adherens junction organization	IMP IMP: Inferred from mutant phenotype	30639848	MGI
involved in cochlea development	IMP IMP: Inferred from mutant phenotype	30639848	MGI
involved in epidermal growth factor receptor ligand maturation	IMP IMP: Inferred from mutant phenotype	14993236	MGI
involved in in utero embryonic development	IMP IMP: Inferred from mutant phenotype	12354787	MGI
involved in membrane protein ectodomain proteolysis	IDA IDA: Inferred from direct assay	17245433	MGI
involved in membrane protein ectodomain proteolysis	IMP IMP: Inferred from mutant phenotype	29325091	MGI
involved in pore complex assembly	IMP IMP: Inferred from mutant phenotype	30463011	MGI
involved in postsynapse organization	EXP EXP: Inferred from Experiment	21123580	MGI
involved in postsynapse organization	IDA IDA: Inferred from direct assay	21123580	MGI
involved in protein catabolic process at postsynapse	EXP EXP: Inferred from Experiment	23083742	MGI
involved in protein catabolic process at postsynapse	IDA IDA: Inferred from direct assay	23083742	MGI
involved in protein catabolic process at postsynapse	IEP IEP: Inferred from expression pattern	23083742	MGI
involved in protein catabolic process at postsynapse	IMP IMP: Inferred from mutant phenotype	23083742	MGI
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	12176995	MGI
acts upstream of or within protein processing	IDA IDA: Inferred from direct assay	20383322	MGI
involved in regulation of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	29397483	MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	EXP EXP: Inferred from Experiment	21123580	MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	21123580	MGI
involved in regulation of postsynapse organization	EXP EXP: Inferred from Experiment	23083742	MGI
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	23083742	MGI
involved in regulation of postsynapse organization	IEP IEP: Inferred from expression pattern	23083742	MGI
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	23083742	MGI
involved in regulation of vasculature development	IMP IMP: Inferred from mutant phenotype	29397483	MGI
involved in signaling receptor ligand precursor processing	IMP IMP: Inferred from mutant phenotype	14993236	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	28032533	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	12176995	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	21123580	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21123580	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	23083742	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	23083742	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12176995	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	29325091	MGI
is active in plasma membrane	IMP IMP: Inferred from mutant phenotype	14993236	MGI
part of pore complex	IMP IMP: Inferred from mutant phenotype	30463011	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	17301176	MGI
located in synaptic membrane	IDA IDA: Inferred from direct assay	23676497	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Adam10 Protein Structure

Pep_M12B_propep

ZnMc_TACE_like

DISIN

0
200
400
600
749 a.a.

Protein Preferred Names

Protein Names

disintegrin and metalloproteinase domain-containing protein 10

a disintegrin and metalloprotease domain (ADAM) 10	kuzbanian protein homolog
mammalian disintegrin-metalloprotease

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10293	Aderbasib	Inhibitor	99.44%	Phase 2

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115670	GW280264X	Inhibitor	98.28%	Unkown
HY-110397	KP-457	Inhibitor	99.18%	Unkown
HY-120852	JG26	Inhibitor	98.01%	Unkown
HY-108675	PPNDS tetrasodium	Inhibitor	96.39%	Unkown
HY-P3722A	Mca-PLAQAV-Dpa-RSSSR-NH2 TFA		99.21%	Unkown
HY-P3722	Mca-PLAQAV-Dpa-RSSSR-NH2		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adam10	NCBI	NCBI:102

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