OSBPL10 - oxysterol binding protein like 10 Gene

Homo sapiens

Also known as ORP10; OSBP9

Gene ID: 114884 | Gene type: protein coding

About OSBPL10

Cytogenetic location: 3p23-p22.3 Genomic coordinates (GRCh38): 3:31,660,825-32,077,692 (from NCBI)

This gene has 20 transcripts (splice variants), 251 orthologues and 11 paralogues. Broad expression in testis (RPKM 5.3), placenta (RPKM 5.2) and 23 other tissues.

Summary

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

OSBPL10 Products(2)

mRNA	Protein	Name
NM_001174060.2	NP_001167531.1	oxysterol-binding protein-related protein 10 isoform 2
NM_017784.5	NP_060254.2	oxysterol-binding protein-related protein 10 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables cholesterol binding	IDA IDA: Inferred from direct assay	17428193	GOA
enables phosphatidylserine binding	IDA IDA: Inferred from direct assay	23934110	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19615732	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OSBPL10 Protein Structure

PH_8

Oxysterol_BP

0
200
400
600
764 a.a.

Protein Preferred Names

Protein Names

oxysterol-binding protein-related protein 10

ORP-10

OSBPL10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	OSBPL10	Q9BXB5	OSBPL9	Homo sapiens	Q96SU4	BiFC	22906437
Intra	OSBPL10	Q9BXB5	OSBPL9	Homo sapiens	Q96SU4	Anti Tag CoIP	22906437

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09837	OSBPL10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	OSBPL10	MGD	MGI:1921736
Bos taurus	OSBPL10	VGNC	VGNC:32458
Macaca mulatta	OSBPL10	VGNC	VGNC:75629
Felis catus	OSBPL10	VGNC	VGNC:63976
Rattus norvegicus	OSBPL10	RGD	RGD:1561652
Canis familiaris	OSBPL10	VGNC	VGNC:44151

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