OSBPL11 - oxysterol binding protein like 11 Gene

Homo sapiens

Also known as ORP11; ORP-11; OSBP12; TCCCIA00292

Gene ID: 114885 | Gene type: protein coding

About OSBPL11

Cytogenetic location: 3q21.2 Genomic coordinates (GRCh38): 3:125,528,858-125,595,497 (from NCBI)

This gene has 1 transcript (splice variant), 211 orthologues and 11 paralogues. Ubiquitous expression in spleen (RPKM 8.5), brain (RPKM 8.2) and 25 other tissues.

Summary

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. [provided by RefSeq, Jul 2008]

OSBPL11 Products(1)

mRNA	Protein	Name
NM_022776.5	NP_073613.2	oxysterol-binding protein-related protein 11

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19615732	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in fat cell differentiation	IMP IMP: Inferred from mutant phenotype	23028956	GOA
involved in positive regulation of sequestering of triglyceride	IMP IMP: Inferred from mutant phenotype	23028956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OSBPL11 Protein Structure

Oxysterol_BP

0
200
400
600
747 a.a.

Protein Preferred Names

Protein Names

oxysterol-binding protein-related protein 11

OSBP-related protein 11

OSBPL11 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	OSBPL11	Q9BXB4	OSBPL9	Homo sapiens	Q96SU4	Anti Tag CoIP	35271311
Intra	OSBPL11	Q9BXB4	OSBPL9	Homo sapiens	Q96SU4	BiFC	22906437

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Splenic Manifestation Of Leukemia

Splenic Leukemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09838	OSBPL11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	OSBPL11	VGNC	VGNC:75631
Bos taurus	OSBPL11	VGNC	VGNC:32459
Mus musculus	OSBPL11	MGD	MGI:2146553
Canis familiaris	OSBPL11	VGNC	VGNC:44152
Felis catus	OSBPL11	VGNC	VGNC:63977
Rattus norvegicus	OSBPL11	RGD	RGD:1307294

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