C1QTNF4 - C1q and TNF related 4 Gene

Homo sapiens

Also known as CTRP4; ZACRP4

Gene ID: 114900 | Gene type: protein coding

About C1QTNF4

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:47,589,667-47,595,304 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 173 orthologues and 23 paralogues. Biased expression in brain (RPKM 5.9), bone marrow (RPKM 0.3) and 2 other tissues.

Summary

Predicted to enable cytokine activity. Involved in positive regulation of cytokine production and positive regulation of signal transduction. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

C1QTNF4 Products(1)

mRNA	Protein	Name
NM_031909.3	NP_114115.2	complement C1q tumor necrosis factor-related protein 4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	21658842	GOA
involved in positive regulation of interleukin-6-mediated signaling pathway	IDA IDA: Inferred from direct assay	21658842	GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	21658842	GOA
involved in positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	21658842	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	21658842	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C1QTNF4 Protein Structure

C1q

0
100
200
300
329 a.a.

Protein Preferred Names

Protein Names

complement C1q tumor necrosis factor-related protein 4

C1q and tumor necrosis factor related protein 4

C1QTNF4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	C1QTNF4	Q9BXJ3	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	C1QTNF4	Q9BXJ3	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	C1QTNF4	Q9BXJ3	L3MBTL3	Homo sapiens	Q96JM7-2	Y2H Array	32296183
Intra	C1QTNF4	Q9BXJ3	L3MBTL3	Homo sapiens	Q96JM7-2	Y2H Prey Pooling	32296183
Intra	C1QTNF4	Q9BXJ3	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	32296183
Intra	C1QTNF4	Q9BXJ3	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	C1QTNF4	Q9BXJ3	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32296183
Intra	C1QTNF4	Q9BXJ3	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	C1QTNF4	Q9BXJ3	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	C1QTNF4	Q9BXJ3	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01730	C1QTNF4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	C1QTNF4	RGD	RGD:1311006
Mus musculus	C1QTNF4	MGD	MGI:1914695
Macaca mulatta	C1QTNF4	VGNC	VGNC:70313
Canis familiaris	C1QTNF4	VGNC	VGNC:51856
Felis catus	C1QTNF4	VGNC	VGNC:81910

Name
Email *

	Sorry, but the email address you supplied was invalid.