FCHO2 - FCH and mu domain containing endocytic adaptor 2 Gene

Homo sapiens

Gene ID: 115548 | Gene type: protein coding

About FCHO2

Cytogenetic location: 5q13.2 Genomic coordinates (GRCh38): 5:72,956,041-73,090,522 (from NCBI)

This gene has 7 transcripts (splice variants), 222 orthologues and 5 paralogues. Ubiquitous expression in esophagus (RPKM 12.4), thyroid (RPKM 12.1) and 25 other tissues.

Summary

Enables identical protein binding activity. Involved in clathrin coat assembly and clathrin-dependent endocytosis. Located in clathrin-coated pit and clathrin-coated vesicle. [provided by Alliance of Genome Resources, Apr 2022]

FCHO2 Products(2)

mRNA	Protein	Name
NM_001146032.2	NP_001139504.1	F-BAR domain only protein 2 isoform b
NM_138782.3	NP_620137.2	F-BAR domain only protein 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	17540576	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19380743	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in clathrin coat assembly	IMP IMP: Inferred from mutant phenotype	20448150	GOA
involved in clathrin-dependent endocytosis	IMP IMP: Inferred from mutant phenotype	20448150	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in clathrin-coated pit	IDA IDA: Inferred from direct assay	21762413	GOA
located in clathrin-coated vesicle	IDA IDA: Inferred from direct assay	21762413	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FCHO2 Protein Structure

FCH

muHD

0
200
400
600
810 a.a.

Protein Preferred Names

Protein Names

F-BAR domain only protein 2

FCH domain only 2

FCHO2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	FCHO2	Q0JRZ9	Dab2	Mus musculus	P98078	Pull Down	22323290
Cross	FCHO2	Q0JRZ9	Dab2	Mus musculus	P98078	Anti Tag CoIP	22323290
Intra	FCHO2	Q0JRZ9	EPS15	Homo sapiens	P42566	Confocal	21762413
Intra	FCHO2	Q0JRZ9	EPS15	Homo sapiens	P42566	Anti Bait CoIP	21762413

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cardiomyopathy, Familial Hypertrophic, 2

Hypertrophic Cardiomyopathy 2	CMH2
Cardiomyopathy, Hypertrophic, 2	Cardiomyopathy Familial Hypertrophic 2
Cardiomyopathy, Familial Hypertrophic 2	Cardiomyopathy, Hypertrophic, Familial, Type 2

Developmental And Epileptic Encephalopathy 4

DEE4	Epileptic Encephalopathy, Early Infantile, 4
Eiee4	Early Infantile Epileptic Encephalopathy 4
Stxbp1-Related Early-Onset Encephalopathy	Early Myoclonic Encephalopathy
Developmental And Epileptic Encephalopathy, 4	Stxbp1 Disorders
Stxbp1 Encephalopathy	Developmental And Epileptic Encephalopathy, Type 4
Early-Infantile Epileptic Encephalopathy 4	Stxbp1 Encephalopathy With Epilepsy
Stxbp1 Epileptic Encephalopathy	Stxbp1-Related Developmental And Epileptic Encephalopathy
Stxbp1-Related Epileptic Encephalopathy	Eme
Neonatal Epilepsy With Suppression-Burst Pattern	Encephalopathy, Epileptic, Early Infantile, Type 4

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04835	FCHO2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FCHO2	RGD	RGD:1565396
Macaca mulatta	FCHO2	VGNC	VGNC:72571
Canis familiaris	FCHO2	VGNC	VGNC:40805
Bos taurus	FCHO2	VGNC	VGNC:28936
Mus musculus	FCHO2	MGD	MGI:3505790
Felis catus	FCHO2	VGNC	VGNC:62211

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