DIS3L - DIS3 like exosome 3'-5' exoribonuclease Gene

Homo sapiens

Also known as DIS3L1

Gene ID: 115752 | Gene type: protein coding

About DIS3L

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:66,293,309-66,333,898 (from NCBI)

This gene has 14 transcripts (splice variants), 196 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 7.4), testis (RPKM 7.4) and 25 other tissues.

Summary

The cytoplasmic RNA exosome complex degrades unstable mRNAs and is involved in the regular turnover of other mRNAs. The protein encoded by this gene contains 3'-5' exoribonuclease activity and is a catalytic component of this complex. [provided by RefSeq, May 2016]

DIS3L Products(13)

mRNA	Protein	Name
NM_001143688.3	NP_001137160.1	DIS3-like exonuclease 1 isoform 1
NM_001323936.2	NP_001310865.1	DIS3-like exonuclease 1 isoform 2
NM_001323937.2	NP_001310866.1	DIS3-like exonuclease 1 isoform 5
NM_001323938.2	NP_001310867.1	DIS3-like exonuclease 1 isoform 3
NM_001323939.2	NP_001310868.1	DIS3-like exonuclease 1 isoform 3
NM_001323940.2	NP_001310869.1	DIS3-like exonuclease 1 isoform 4
NM_001323941.2	NP_001310870.1	DIS3-like exonuclease 1 isoform 3
NM_001323943.2	NP_001310872.1	DIS3-like exonuclease 1 isoform 4
NM_001323944.2	NP_001310873.1	DIS3-like exonuclease 1 isoform 6
NM_001323945.2	NP_001310874.1	DIS3-like exonuclease 1 isoform 2
NM_001323946.2	NP_001310875.1	DIS3-like exonuclease 1 isoform 3
NM_001323948.2	NP_001310877.1	DIS3-like exonuclease 1 isoform 7
NM_133375.5	NP_588616.1	DIS3-like exonuclease 1 isoform 2

DIS3L Protein Structure

RNB

0
200
400
600
800
1000
1054 a.a.

Protein Preferred Names

Protein Names

DIS3-like exonuclease 1

DIS3 mitotic control homolog-like

Related Diseases

Diseases

Alias

Perlman Syndrome

Nephroblastomatosis, Fetal Ascites, Macrosomia And Wilms Tumor	PRLMNS
Renal Hamartomas, Nephroblastomatosis, And Fetal Gigantism	Nephroblastomatosis Fetal Ascites Macrosomia And Wilms Tumor
Nephroblastomatosis, Fetal Ascites, Macrosomia, And Wilms Tumor	Nephroblastomatosis - Fetal Ascites - Macrosomia - Wilms Tumor
Renal Hamartomas, Nephroblastomatosis And Fetal Gigantism	Nephroblastomatosis-Fetal Ascites-Macrosomia-Wilms Tumor Syndrome
Renal Hamartomas Nephroblastomatosis And Fetal Gigantism	Nephroblastoma
Fetal Macrosomia

Trichohepatoenteric Syndrome 1

Trichohepatoenteric Syndrome	Syndromic Diarrhea
Tricho-Hepato-Enteric Syndrome	Sd/The
Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome	THES1
Phenotypic Diarrhea	Thes
Phenotypic Diarrhea Of Infancy	Diarrhea, Syndromic
Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa	Intractable Diarrhea With Phenotypic Anomalies
Syndromatic Diarrhea	Fatal Infantile Diarrhea With Trichorrhexis Nodosa

Trichohepatoenteric Syndrome 2

THES2

Pontocerebellar Hypoplasia

Pch	Congenital Pontocerebellar Hypoplasia
Opch	Hypoplasia, Pontocerebellar
Pontoneocerebellar Hypoplasia	Nonsyndromic Pontocerebellar Hypoplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03779	DIS3L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03780	DIS3L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DIS3L	MGD	MGI:2143272
Bos taurus	DIS3L	VGNC	VGNC:28073
Canis familiaris	DIS3L	VGNC	VGNC:39963
Macaca mulatta	DIS3L	VGNC	VGNC:71796
Rattus norvegicus	DIS3L	RGD	RGD:1308959
Felis catus	DIS3L	VGNC	VGNC:61500

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