ARL11 - ADP ribosylation factor like GTPase 11 Gene

Homo sapiens

Also known as ARLTS1

Gene ID: 115761 | Gene type: protein coding

About ARL11

Cytogenetic location: 13q14.2 Genomic coordinates (GRCh38): 13:49,628,507-49,633,872 (from NCBI)

This gene has 2 transcripts (splice variants), 93 orthologues, 30 paralogues and is associated with 1 phenotype. Broad expression in lymph node (RPKM 2.7), spleen (RPKM 2.1) and 17 other tissues.

Summary

This gene encodes a tumor suppressor related to the ADP-ribosylation factor (ARF) family of proteins. The encoded protein may play a role in Apoptosis in a caspase-dependent manner. Polymorphisms in this gene have been associated with some familial cancers. [provided by RefSeq, May 2010]

ARL11 Products(1)

mRNA	Protein	Name
NM_138450.6	NP_612459.1	ADP-ribosylation factor-like protein 11

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARL11 Protein Structure

Arf

0
100
196 a.a.

Protein Preferred Names

Protein Names

ADP-ribosylation factor-like protein 11

ADP-ribosylation factor-like 11

ARL11 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ARL11	Q969Q4	TRIP13	Homo sapiens	Q15645	Y2H Array	19060904
Intra	ARL11	Q969Q4	TRIP13	Homo sapiens	Q15645	Y2H Pooling	19060904

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Chronic Leukemia

Adult Chronic Leukemia	Cll
Cml

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00979	ARL11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ARL11	VGNC	VGNC:26137
Rattus norvegicus	ARL11	RGD	RGD:1308083
Macaca mulatta	ARL11	VGNC	VGNC:69889
Mus musculus	ARL11	MGD	MGI:2444054

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