RAB3C - RAB3C, member RAS oncogene family Gene

Homo sapiens

Gene ID: 115827 | Gene type: protein coding

About RAB3C

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:58,582,152-58,859,394 (from NCBI)

This gene has 4 transcripts (splice variants), 220 orthologues and 68 paralogues. Biased expression in brain (RPKM 24.5) and adrenal (RPKM 6.1).

Summary

This gene is a member of the Ras oncogene family and encodes a small GTPase. Other similar small GTPases are known to be involved in vesicle trafficking, and the encoded protein was shown to play a role in recycling phagocytosed MHC class 1 complexes to the cell surface. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

RAB3C Products(2)

mRNA	Protein	Name
NM_001317915.2	NP_001304844.1	ras-related protein Rab-3C isoform 2
NM_138453.4	NP_612462.1	ras-related protein Rab-3C isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activity	IDA IDA: Inferred from direct assay	24891604	GOA
enables myosin V binding	IPI IPI: Inferred from physical interaction	24006491	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24891604	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antigen processing and presentation	IMP IMP: Inferred from mutant phenotype	19717423	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	19717423	GOA
located in vesicle	IDA IDA: Inferred from direct assay	19717423	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB3C Protein Structure

Ras

0
100
200
227 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rab-3C

RAB3C Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAB3C	Q96E17	NEK7	Homo sapiens	Q8TDX7	Validated Y2H	32814053
Intra	RAB3C	Q96E17	NEK7	Homo sapiens	Q8TDX7	Y2H Array	32814053
Intra	RAB3C	Q96E17	NEK7	Homo sapiens	Q8TDX7	Y2H Pooling	32814053
Intra	RAB3C	Q96E17	VRTN	Homo sapiens	Q9H8Y1	Validated Y2H	32296183
Intra	RAB3C	Q96E17	VRTN	Homo sapiens	Q9H8Y1	Y2H Array	32296183
Intra	RAB3C	Q96E17	VRTN	Homo sapiens	Q9H8Y1	Y2H Prey Pooling	32296183
Intra	RAB3C	Q96E17	ITM2B	Homo sapiens	Q9Y287	Y2H Array	32814053
Intra	RAB3C	Q96E17	ITM2B	Homo sapiens	Q9Y287	Validated Y2H	32814053
Intra	RAB3C	Q96E17	ITM2B	Homo sapiens	Q9Y287	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Warburg Micro Syndrome 1

Warburg Micro Syndrome	Micro Syndrome
Warbm	WARBM1
Warburg Sjo Fledelius Syndrome	Warburg-Sjo-Fledelius Syndrome
Micro Syndrome 1	Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism

Focal Epithelial Hyperplasia

Heck'S Disease	Heck Disease
Multifocal Epithelial Hyperplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11557	RAB3C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RAB3C	VGNC	VGNC:97591
Rattus norvegicus	RAB3C	RGD	RGD:620923
Mus musculus	RAB3C	MGD	MGI:1914545
Canis familiaris	RAB3C	VGNC	VGNC:45284
Bos taurus	RAB3C	VGNC	VGNC:33651
Macaca mulatta	RAB3C	VGNC	VGNC:81541

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