FOXP4 - forkhead box P4 Gene

Homo sapiens

Also known as hFKHLA

Gene ID: 116113 | Gene type: protein coding

About FOXP4

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,546,381-41,602,384 (from NCBI)

This gene has 9 transcripts (splice variants), 190 orthologues, 4 paralogues and is associated with 1 phenotype. Ubiquitous expression in stomach (RPKM 7.0), testis (RPKM 4.6) and 25 other tissues.

Summary

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. [provided by RefSeq, Jul 2008]

FOXP4 Products(6)

mRNA	Protein	Name
NM_001012426.2	NP_001012426.1	forkhead box protein P4 isoform 1
NM_001012427.2	NP_001012427.1	forkhead box protein P4 isoform 3
NM_001405824.1	NP_001392753.1	forkhead box protein P4 isoform 4
NM_001405825.1	NP_001392754.1	forkhead box protein P4 isoform 5
NM_001405826.1	NP_001392755.1	forkhead box protein P4 isoform 6
NM_138457.3	NP_612466.1	forkhead box protein P4 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19907493	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXP4 Protein Structure

Forkhead

0
200
400
600
680 a.a.

Protein Preferred Names

Protein Names

forkhead box protein P4

fork head-related protein like A

FOXP4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FOXP4	Q8IVH2	FOXP2	Homo sapiens	O15409	TAP	25609649
Intra	FOXP4	Q8IVH2	FOXP1	Homo sapiens	Q9H334	TAP	25609649

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ventricular Septal Defect

Ventricular Septal Defects	Interventricular Septal Defect
Heart Septal Defects, Ventricular	Ventricular Septal Abnormality
Interventricular Septum Defect	Ventricular Septum Defect
Vsd - [Ventricular Septum Defect]	Congenital Ventricular Septal Defect
Single Ventricular Septal Defect

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Intellectual Disability-Severe Speech Delay-Mild Dysmorphism Syndrome

Foxp1 Syndrome	Mental Retardation With Language Impairment And With Or Without Autistic Features
Foxp1 Related Global Developmental Delay, Intellectual Disability And Speech Defects	Intellectual Disability With Language Impairment And With Or Without Autistic Features

Speech Disorder

Speech Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05076	FOXP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FOXP4	VGNC	VGNC:62346
Macaca mulatta	FOXP4	VGNC	VGNC:72755
Mus musculus	FOXP4	MGD	MGI:1921373
Canis familiaris	FOXP4	VGNC	VGNC:40968
Rattus norvegicus	FOXP4	RGD	RGD:1311386
Bos taurus	FOXP4	VGNC	VGNC:29103

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