FOXP1 - forkhead box P1 Gene

Homo sapiens

Also known as MFH; QRF1; 12CC4; hFKH1B; HSPC215

Gene ID: 27086 | Gene type: protein coding

About FOXP1

Cytogenetic location: 3p13 Genomic coordinates (GRCh38): 3:70,954,708-71,583,978 (from NCBI)

This gene has 71 transcripts (splice variants), 131 orthologues, 42 paralogues and is associated with 104 phenotypes. Ubiquitous expression in lung (RPKM 7.3), ovary (RPKM 7.1) and 25 other tissues.

Summary

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

FOXP1 Products(17)

mRNA	Protein	Name
NM_001012505.2	NP_001012523.1	forkhead box protein P1 isoform b
NM_001244808.3	NP_001231737.1	forkhead box protein P1 isoform c
NM_001244810.2	NP_001231739.1	forkhead box protein P1 isoform d
NM_001244812.3	NP_001231741.1	forkhead box protein P1 isoform e
NM_001244813.3	NP_001231742.1	forkhead box protein P1 isoform f
NM_001244814.3	NP_001231743.1	forkhead box protein P1 isoform a
NM_001244815.2	NP_001231744.2	forkhead box protein P1 isoform f
NM_001244816.2	NP_001231745.1	forkhead box protein P1 isoform a
NM_001349337.2	NP_001336266.2	forkhead box protein P1 isoform i
NM_001349338.3	NP_001336267.1	forkhead box protein P1 isoform a
NM_001349340.3	NP_001336269.1	forkhead box protein P1 isoform a
NM_001349341.3	NP_001336270.1	forkhead box protein P1 isoform j
NM_001349342.3	NP_001336271.1	forkhead box protein P1 isoform f
NM_001349343.3	NP_001336272.1	forkhead box protein P1 isoform i
NM_001349344.3	NP_001336273.1	forkhead box protein P1 isoform i
NM_001370548.1	NP_001357477.1	forkhead box protein P1 isoform k
NM_032682.6	NP_116071.2	forkhead box protein P1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables core promoter sequence-specific DNA binding	IDA IDA: Inferred from direct assay	28218735	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25609649	GOA
enables nuclear androgen receptor binding	IDA IDA: Inferred from direct assay	18640093	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18347093	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	30111844	GOA
involved in endothelial cell activation	IMP IMP: Inferred from mutant phenotype	24023716	GOA
involved in macrophage activation	IDA IDA: Inferred from direct assay	18799727	GOA
involved in monocyte activation	IDA IDA: Inferred from direct assay	18799727	GOA
involved in negative regulation of B cell apoptotic process	IDA IDA: Inferred from direct assay	25267198	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20950788	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	26647308	GOA
involved in negative regulation of androgen receptor signaling pathway	IDA IDA: Inferred from direct assay	18640093	GOA
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	30111844	GOA
involved in osteoclast development	IDA IDA: Inferred from direct assay	18799727	GOA
involved in osteoclast differentiation	IDA IDA: Inferred from direct assay	18799727	GOA
involved in positive regulation of B cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	30111844	GOA
involved in positive regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	24023716	GOA
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	24023716	GOA
involved in regulation of chemokine (C-X-C motif) ligand 2 production	IDA IDA: Inferred from direct assay	18799727	GOA
involved in regulation of defense response to bacterium	IDA IDA: Inferred from direct assay	18799727	GOA
involved in regulation of endothelial tube morphogenesis	IMP IMP: Inferred from mutant phenotype	24023716	GOA
involved in regulation of gene expression	IMP IMP: Inferred from mutant phenotype	28218735	GOA
involved in regulation of inflammatory response	IDA IDA: Inferred from direct assay	18799727	GOA
involved in regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	18799727	GOA
involved in regulation of interleukin-12 production	IDA IDA: Inferred from direct assay	18799727	GOA
involved in regulation of macrophage colony-stimulating factor production	IDA IDA: Inferred from direct assay	18799727	GOA
involved in regulation of monocyte differentiation	IDA IDA: Inferred from direct assay	15286807	GOA
involved in regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	18799727	GOA
involved in response to lipopolysaccharide	IDA IDA: Inferred from direct assay	18799727	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	25027557	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXP1 Protein Structure

Forkhead

0
200
400
600
677 a.a.

Protein Preferred Names

Protein Names

forkhead box protein P1

fork head-related protein like B

Related Diseases

Diseases

Alias

Intellectual Disability-Severe Speech Delay-Mild Dysmorphism Syndrome

Foxp1 Syndrome	Mental Retardation With Language Impairment And With Or Without Autistic Features
Foxp1 Related Global Developmental Delay, Intellectual Disability And Speech Defects	Intellectual Disability With Language Impairment And With Or Without Autistic Features

Intellectual Developmental Disorder With Language Impairment And With Or Without Autistic Features

Mental Retardation With Language Impairment And With Or Without Autistic Features	Intellectual Developmental Disorder With Language Impairment With Or Without Autistic Features
MRLIAF

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Atrial Septal Defect 1

ASD1	Atrial Heart Septal Defect 1
Asd

Lymphoma, Mucosa-Associated Lymphoid Type

Malt Lymphoma	Gastric Lymphoma, Primary
Lymphoma, Malt, Somatic	Mucosa-Associated Lymphoid Tissue Lymphoma
Extranodal Marginal Zone B-Cell Lymphoma	MALTOMA
Marginal Zone B-Cell Lymphoma	Mucosa-Associated Lymphatic Tissue Lymphoma
Primary Gastric Lymphoma	Gastric Lymphoma
Familial Primary Gastric Lymphoma

B-Lymphoblastic Leukemia/Lymphoma With Recurrent Genetic Abnormality

Earlobe Crease

Rare Genetic Intellectual Disability

Strabismus

Strabismus, Susceptibility To	Strabismus, Susceptibility To, 1
Strabismus 1

Speech Disorder

Speech Disorders

B-Cell Lymphoma

Lymphoma, B-Cell	B-Cell Lymphomas
B-Cell Lymphocytic Neoplasm	Lymphoma B-Cell
B-Cell Lymphoma Nos

B-Lymphoblastic Leukemia/Lymphoma, Bcr-Abl1-Like

B Lymphoblastic Leukemia/Lymphoma, Bcr-Abl1-Like

B-All Bcr-Abl1-Like

Blepharophimosis

Hypogonadotropic Hypogonadism 4 With Or Without Anosmia

HH4	Kallmann Syndrome 4
Kal4	Hypogonadotropic Hypogonadism, Type 4 With/Without Anosmia

Megalencephaly

Macroencephaly

Macrencephaly

Alpha Chain Disease

Seligmann'S Disease

Immunoproliferative Small Intestinal Disease

Orbit Lymphoma

Orbital Lymphoma

Lymphoma Of The Orbit

Speech And Communication Disorders

Language Disorder	Communication Disorder
Language Disorders	Communication Disorders
Speech Language Disorder	Speech-Language Disorder
Communication Impairment	Speech And Language Disorder

Congenital Disorder Of Glycosylation, Type Ig

CDG1G	Alg12-Congenital Disorder Of Glycosylation
Cdg Ig	Congenital Disorder Of Glycosylation Type 1g
Congenital Disorder Of Glycosylation Type Ig	Cdgig
Congenital Disorder Of Glycosylation Ig	Congenital Disorder Of Glycosylation 1g
Cdg-Ig	Alg12-Cdg
Cdg Syndrome Type Ig	Carbohydrate Deficient Glycoprotein Syndrome Type Ig
Mannosyltransferase 8 Deficiency	Glycosylation, Congenital Disorder Of, Type Ig

Marginal Zone B-Cell Lymphoma

Marginal Zone Lymphoma	Mzl
Mucosa-Associated Lymphoid Tissue Lymphoma

Specific Language Impairment

Language Impairment, Specific

Huntington Disease

Huntington'S Disease	Huntington Chorea
Huntington'S Chorea	HD
Huntington Chronic Progressive Hereditary Chorea	Juvenile Huntington Disease
Chronic Progressive Chorea	Chronic Progressive Hereditary Chorea
Hc - [Huntington Chorea]	Hereditary Chorea
Progressive Hereditary Chorea

Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05073	FOXP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FOXP1	VGNC	VGNC:29101
Felis catus	FOXP1	VGNC	VGNC:62345
Mus musculus	FOXP1	MGD	MGI:1914004
Rattus norvegicus	FOXP1	RGD	RGD:1308669
Canis familiaris	FOXP1	VGNC	VGNC:40965
Macaca mulatta	FOXP1	VGNC	VGNC:84173

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