PHACTR3 - phosphatase and actin regulator 3 Gene

Homo sapiens

Also known as H17739; SCAPIN1; PPP1R123; SCAPININ; C20orf101

Gene ID: 116154 | Gene type: protein coding

About PHACTR3

Cytogenetic location: 20q13.32-q13.33 Genomic coordinates (GRCh38): 20:59,577,509-59,847,711 (from NCBI)

This gene has 9 transcripts (splice variants), 273 orthologues and 3 paralogues. Biased expression in brain (RPKM 9.3), spleen (RPKM 1.0) and 2 other tissues.

Summary

This gene encodes a member of the Phosphatase and actin regulator protein family. The encoded protein is associated with the nuclear scaffold in proliferating cells, and binds to actin and the catalytic subunit of protein phosphatase-1, suggesting that it functions as a regulatory subunit of protein phosphatase-1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

PHACTR3 Products(6)

mRNA	Protein	Name
NM_001199505.1	NP_001186434.1	phosphatase and actin regulator 3 isoform 4
NM_001199506.2	NP_001186435.1	phosphatase and actin regulator 3 isoform 2
NM_001281507.2	NP_001268436.1	phosphatase and actin regulator 3 isoform 2
NM_080672.5	NP_542403.1	phosphatase and actin regulator 3 isoform 1
NM_183244.2	NP_899067.1	phosphatase and actin regulator 3 isoform 2
NM_183246.2	NP_899069.1	phosphatase and actin regulator 3 isoform 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHACTR3 Protein Structure

RPEL

0
100
200
300
400
500
559 a.a.

Protein Preferred Names

Protein Names

phosphatase and actin regulator 3

protein phosphatase 1, regulatory subunit 123

PHACTR3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PHACTR3	Q96KR7	CAPNS2	Homo sapiens	Q96L46	Validated Y2H	32296183
Intra	PHACTR3	Q96KR7	UBIAD1	Homo sapiens	Q9Y5Z9	Validated Y2H	32296183
Intra	PHACTR3	Q96KR7	PPP1CB	Homo sapiens	P62140	Y2H Array	32296183
Intra	PHACTR3	Q96KR7	PPP1CB	Homo sapiens	P62140	Y2H Prey Pooling	32296183
Intra	PHACTR3	Q96KR7	UBL5	Homo sapiens	Q9BZL1	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Inflammatory Bowel Disease 9

IBD9

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10404	PHACTR3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PHACTR3	MGD	MGI:1921439
Rattus norvegicus	PHACTR3	RGD	RGD:1303029
Felis catus	PHACTR3	VGNC	VGNC:64130
Canis familiaris	PHACTR3	VGNC	VGNC:44474
Bos taurus	PHACTR3	VGNC	VGNC:57015
Macaca mulatta	PHACTR3	VGNC	VGNC:75805

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