2. Gene
  3. PHACTR3 - phosphatase and actin regulator 3 Gene

PHACTR3 - phosphatase and actin regulator 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as H17739; SCAPIN1; PPP1R123; SCAPININ; C20orf101

Gene ID: 116154 | Gene type: protein coding

About PHACTR3

Cytogenetic location: 20q13.32-q13.33 Genomic coordinates (GRCh38): 20:59,577,509-59,847,711 (from NCBI)

This gene has 9 transcripts (splice variants), 273 orthologues and 3 paralogues. Biased expression in brain (RPKM 9.3), spleen (RPKM 1.0) and 2 other tissues.

Summary

This gene encodes a member of the Phosphatase and actin regulator protein family. The encoded protein is associated with the nuclear scaffold in proliferating cells, and binds to actin and the catalytic subunit of protein phosphatase-1, suggesting that it functions as a regulatory subunit of protein phosphatase-1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

PHACTR3 Products(6)

mRNA Protein Name
NM_001199505.1 NP_001186434.1 phosphatase and actin regulator 3 isoform 4
NM_001199506.2 NP_001186435.1 phosphatase and actin regulator 3 isoform 2
NM_001281507.2 NP_001268436.1 phosphatase and actin regulator 3 isoform 2
NM_080672.5 NP_542403.1 phosphatase and actin regulator 3 isoform 1
NM_183244.2 NP_899067.1 phosphatase and actin regulator 3 isoform 2
NM_183246.2 NP_899069.1 phosphatase and actin regulator 3 isoform 3
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHACTR3 Protein Structure

RPEL

RPEL: RPEL repeat (440 - 464)

RPEL

RPEL: RPEL repeat (478 - 500)

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  • 559 a.a.
Protein Preferred Names Protein Names

phosphatase and actin regulator 3

protein phosphatase 1, regulatory subunit 123

Related Diseases

Diseases Alias
Inflammatory Bowel Disease 9

IBD9
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10404 PHACTR3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PHACTR3 MGD MGI:1921439
Rattus norvegicus PHACTR3 RGD RGD:1303029
Felis catus PHACTR3 VGNC VGNC:64130
Canis familiaris PHACTR3 VGNC VGNC:44474
Bos taurus PHACTR3 VGNC VGNC:57015
Macaca mulatta PHACTR3 VGNC VGNC:75805