2. Gene
  3. UBL5 - ubiquitin like 5 Gene

UBL5 - ubiquitin like 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as HUB1

Gene ID: 59286 | Gene type: protein coding

About UBL5

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:9,827,918-9,830,115 (from NCBI)

This gene has 8 transcripts (splice variants) and 189 orthologues. Ubiquitous expression in kidney (RPKM 86.7), adrenal (RPKM 83.4) and 25 other tissues.

Summary

This gene encodes a member of a group of proteins similar to ubiquitin. The encoded protein is not thought to degrade proteins like ubiquitin but to affect their function through being bound to target proteins by an isopeptide bond. The gene product has been studied as a link to predisposition to obesity based on its expression in Psammomys obesus, the fat sand rat, which is an animal model for obesity studies. Variation in this gene was found to be significantly associated with some metabolic traits (PMID: 15331561) but not associated with childhood obesity (PMID: 19189687). Pseudogenes of this gene are located on chromosomes 3, 5 and 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]

UBL5 Products(2)

mRNA Protein Name
NM_001048241.3 NP_001041706.1 ubiquitin-like protein 5
NM_024292.4 NP_077268.1 ubiquitin-like protein 5
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15620657 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11161819 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBL5 Protein Structure

ubiquitin

ubiquitin: Ubiquitin family (11 - 71)

  • 0
  • 73 a.a.
Protein Preferred Names Protein Names

ubiquitin-like protein 5

beacon

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15376 UBL5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus UBL5 RGD RGD:1564644
Mus musculus UBL5 MGD MGI:1913427
Felis catus UBL5 VGNC VGNC:66775
Macaca mulatta UBL5 VGNC VGNC:82266
Canis familiaris UBL5 VGNC VGNC:48078