1. Gene
  2. PPP1CB - protein phosphatase 1 catalytic subunit beta Gene

PPP1CB - protein phosphatase 1 catalytic subunit beta Gene

Homo sapiens

Also known as MP; PP1B; PP1c; NSLH2; PP-1B; PPP1CD; PP1beta; PPP1beta; HEL-S-80p

Gene ID: 5500 | Gene type: protein coding

About PPP1CB

Cytogenetic location: 2p23.2 Genomic coordinates (GRCh38): 2:28,751,604-28,802,940 (from NCBI)

This gene has 16 transcripts (splice variants), 213 orthologues, 12 paralogues and is associated with 3 phenotypes. Ubiquitous expression in esophagus (RPKM 80.9), prostate (RPKM 58.5) and 25 other tissues.

Summary

The protein encoded by this gene is one of the three catalytic subunits of protein Phosphatase 1 (PP1). PP1 is a serine/threonine specific protein Phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

PPP1CB Products(2)

mRNA Protein Name
NM_002709.3 NP_002700.1 serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform 1
NM_206876.2 NP_996759.1 serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables myosin-light-chain-phosphatase activity IDA
IDA: Inferred from direct assay
20354225 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11067852 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
20354225 GOA
Biological Process GO Annotation Evidence Reference Source
involved in regulation of cell adhesion IDA
IDA: Inferred from direct assay
20354225 GOA
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
21712997 GOA
Cellular Component GO Annotation Evidence Reference Source
part of PTW/PP1 phosphatase complex IDA
IDA: Inferred from direct assay
20354225 GOA
colocalizes with chromosome, telomeric region IDA
IDA: Inferred from direct assay
24270157 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP1CB Protein Structure

Metallophos

Metallophos: Calcineurin-like phosphoesterase (58 - 249)

  • 0
  • 100
  • 200
  • 300
  • 327 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase PP1-beta catalytic subunit

epididymis secretory sperm binding protein Li 80p

PPP1CB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PPP1CB P62140 PPP1R7 Homo sapiens Q15435
BioID
28330616
Intra
PPP1CB P62140 PPP1R7 Homo sapiens Q15435
Anti Bait CoIP
17353931
Intra
PPP1CB P62140 PPP1R7 Homo sapiens Q15435
Pull Down
28330616
Intra
PPP1CB P62140 PPP1R7 Homo sapiens Q15435
TAP
27173435
Intra
PPP1CB P62140 PPP1R7 Homo sapiens Q15435
Anti Tag CoIP
26496610
Intra
PPP1CB P62140 PPP1R7 Homo sapiens Q15435
Anti Tag CoIP
27880917
Intra
PPP1CB P62140 PPP1R7 Homo sapiens Q15435
Validated Y2H
32296183
Intra
PPP1CB P62140 PPP1R2B Homo sapiens Q6NXS1
Validated Y2H
25416956
Intra
PPP1CB P62140 PPP1R2B Homo sapiens Q6NXS1
Validated Y2H
32296183
Intra
PPP1CB P62140 PPP1R2B Homo sapiens Q6NXS1
Y2H Array
25416956
Intra
PPP1CB P62140 PPP1R2B Homo sapiens Q6NXS1
Y2H Prey Pooling
32296183
Intra
PPP1CB P62140 PPP1R16B Homo sapiens Q96T49
BFG-2H
27107012
Intra
PPP1CB P62140 PPP1R11 Homo sapiens O60927
Anti Tag CoIP
27880917
Intra
PPP1CB P62140 PPP1R11 Homo sapiens O60927
Anti Tag CoIP
26496610
Intra
PPP1CB P62140 PPP1R11 Homo sapiens O60927
TAP
27173435
Intra
PPP1CB P62140 PPP1R11 Homo sapiens O60927
Anti Bait CoIP
17353931
Intra
PPP1CB P62140 PPP1R11 Homo sapiens O60927
BioID
28330616
Intra
PPP1CB P62140 PPP1R11 Homo sapiens O60927
Pull Down
28330616
Intra
PPP1CB P62140 TP53BP2 Homo sapiens Q05BL1
Validated Y2H
32296183
Intra
PPP1CB P62140 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
Intra
PPP1CB P62140 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
Intra
PPP1CB P62140 SPATC1L Homo sapiens Q9H0A9-2
Validated Y2H
32296183
Intra
PPP1CB P62140 NRAC Homo sapiens Q8N912
Validated Y2H
32296183
Intra
PPP1CB P62140 PPP1R12B Homo sapiens A0A0S2Z4Q8
Y2H Prey Pooling
26871637
Intra
PPP1CB P62140 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
PPP1CB P62140 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
PPP1CB P62140 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
PPP1CB P62140 PPP1R3C Homo sapiens Q9UQK1
Y2H Prey Pooling
25416956
Intra
PPP1CB P62140 PPP1R3C Homo sapiens Q9UQK1
Validated Y2H
25416956
Intra
PPP1CB P62140 PPP1R3C Homo sapiens Q9UQK1
Y2H Prey Pooling
32296183
Intra
PPP1CB P62140 PPP1R3C Homo sapiens Q9UQK1
Validated Y2H
32296183
Intra
PPP1CB P62140 PPP1R3C Homo sapiens Q9UQK1
Y2H Array
32296183
Intra
PPP1CB P62140 KANK2 Homo sapiens Q63ZY3
Validated Y2H
32296183
Intra
PPP1CB P62140 KANK2 Homo sapiens Q63ZY3
Y2H Array
32296183
Intra
PPP1CB P62140 KANK2 Homo sapiens Q63ZY3
Y2H Prey Pooling
32296183
Intra
PPP1CB P62140 PPP1R9B Homo sapiens Q96SB3
Anti Tag CoIP
26496610
Intra
PPP1CB P62140 RRP1B Homo sapiens Q14684
TAP
27173435
Intra
PPP1CB P62140 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
PPP1CB P62140 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
PPP1CB P62140 CSRNP1 Homo sapiens Q96S65
Y2H Array
32296183
Intra
PPP1CB P62140 CSRNP1 Homo sapiens Q96S65
Y2H Prey Pooling
32296183
Intra
PPP1CB P62140 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
PPP1CB P62140 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
PPP1CB P62140 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
PPP1CB P62140 PPP1R27 Homo sapiens Q86WC6
Validated Y2H
32296183
Intra
PPP1CB P62140 CSRNP2 Homo sapiens Q9H175
Y2H Prey Pooling
32296183
Intra
PPP1CB P62140 CSRNP2 Homo sapiens Q9H175
Complementation
32296183
Intra
PPP1CB P62140 CSRNP2 Homo sapiens Q9H175
Y2H Array
25416956
Intra
PPP1CB P62140 CSRNP2 Homo sapiens Q9H175
Y2H Array
32296183
Intra
PPP1CB P62140 CSRNP2 Homo sapiens Q9H175
Validated Y2H
32296183
Intra
PPP1CB P62140 CSRNP2 Homo sapiens Q9H175
Validated Y2H
25416956
Intra
PPP1CB P62140 PPP1R13L Homo sapiens Q8WUF5
TAP
27173435
Intra
PPP1CB P62140 PPP1R13L Homo sapiens Q8WUF5
BioID
28330616
Intra
PPP1CB P62140 PPP1R13L Homo sapiens Q8WUF5
Pull Down
28330616
Intra
PPP1CB P62140 PPP1R13L Homo sapiens Q8WUF5
Anti Tag CoIP
27880917
Intra
PPP1CB P62140 PPP1R13L Homo sapiens Q8WUF5
Anti Tag CoIP
26496610
Intra
PPP1CB P62140 PPP1R16A Homo sapiens Q96I34
Pull Down
28330616
Intra
PPP1CB P62140 PPP1R16A Homo sapiens Q96I34
Y2H Array
25416956
Intra
PPP1CB P62140 PPP1R16A Homo sapiens Q96I34
Validated Y2H
25416956
Intra
PPP1CB P62140 PPP1R16A Homo sapiens Q96I34
Validated Y2H
32296183
Intra
PPP1CB P62140 PHACTR3 Homo sapiens Q96KR7
Validated Y2H
32296183
Intra
PPP1CB P62140 CHCHD3 Homo sapiens Q9NX63
Y2H Prey Pooling
32296183
Intra
PPP1CB P62140 CHCHD3 Homo sapiens Q9NX63
Validated Y2H
32296183
Intra
PPP1CB P62140 CHCHD3 Homo sapiens Q9NX63
Y2H Array
32296183
Intra
PPP1CB P62140 SH2D4A Homo sapiens Q9H788
BFG-2H
27107012
Intra
PPP1CB P62140 SH2D4A Homo sapiens Q9H788
Anti Bait CoIP
17353931
Intra
PPP1CB P62140 SH2D4A Homo sapiens Q9H788
Pull Down
28330616
Intra
PPP1CB P62140 SH2D4A Homo sapiens Q9H788
Validated Y2H
27107012
Intra
PPP1CB P62140 SH2D4A Homo sapiens Q9H788
Y2H Prey Pooling
25416956
Intra
PPP1CB P62140 SH2D4A Homo sapiens Q9H788
Anti Tag CoIP
27880917
Intra
PPP1CB P62140 SH2D4A Homo sapiens Q9H788
Anti Tag CoIP
26496610
Intra
PPP1CB P62140 SH2D4A Homo sapiens Q9H788
BioID
28330616
Intra
PPP1CB P62140 SH2D4A Homo sapiens Q9H788
Validated Y2H
32296183
Intra
PPP1CB P62140 SH2D4A Homo sapiens Q9H788
TAP
27173435
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Noonan Syndrome-Like Disorder With Loose Anagen Hair 2

NSLH2

Noonan Syndrome-Like Disorder With Loose Anagen Hair

Noonan-Like Syndrome With Loose Anagen Hair

Mazzanti Syndrome

Ns/Lah

Pseudo-Turner Syndrome

Noonan Syndrome

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

Dandy-Walker Syndrome

Dandy-Walker Malformation

DWS

Atresia Of Foramina Of Magendie And Luschka

Dandy-Walker Complex

Dandy-Walker Cyst

Dandy-Walker Deformity

Dandy Walker Cyst

Dw Complex

Dandy-Walker Syndrome Or Malformation

Dandy-Walker Variant

Mega Cisterna Magna

Dwm

Hydrocephalus, Internal, Dandy-Walker Type

Hydrocephalus, Noncommunicating, Dandy-Walker Type

Luschka-Magendie Foramina Atresia

Isolated Dandy-Walker Malformation

Mega-Cisterna Magna

Dandy Walker Variant

Atresia Of Foramen Of Luschka

Atresia Of Foramen Of Magendie

Congenital Blockage Of Foramen Magendie

Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis

Neurofibromatosis-Noonan Syndrome

NFNS

Neurofibromatosis Type 1

Neurofibromatosis With Noonan Phenotype

Nf1

Von Recklinghausen Disease

Neurofibromatosis Type 1-Noonan Syndrome

Noonan Neurofibromatosis Syndrome

Recklinghausen'S Disease

Noonan-Neurofibromatosis Syndrome

Fibromatosis Multiple Non Ossifying

Disseminated Nonossifying Fibromas In Association With Cafe-Au-Lait Spots

Jaffe Campanacci Syndrome

Type 1 Neurofibromatosis

Neurofibromatosis 1

Peripheral Neurofibromatosis

Recklinghausen Disease, Nerve

Jaffe-Campanacci Syndrome

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

Cardiofaciocutaneous Syndrome 1

Cardiofaciocutaneous Syndrome

Cfc Syndrome

Cardio-Facio-Cutaneous Syndrome

CFC1

Cfcs

Cardio-Facial-Cutaneous Syndrome

Congenital Heart Defects Characteristic Facial Appearance Ectodermal Abnormalities And Growth Failure

Cardiofaciocutaneous Syndrome, Type 1

Ptosis

Blepharoptosis

Drooping Eyelid

Droopy Eyelid

Ptosis Of Eyelid

Paralysis Of Levator Palpebrae Superioris

Noonan Syndrome With Multiple Lentigines

Leopard Syndrome

Multiple Lentigines Syndrome

Moynahan Syndrome

Cardiomyopathic Lentiginosis

Progressive Cardiomyopathic Lentiginosis

Cardio-Cutaneous Syndrome

Lentiginosis Profusa

Capute-Rimoin-Konigsmark-Esterly-Richardson Syndrome

Generalized Lentiginosis

Gorlin Syndrome Ii

Lentiginosis Profusa Syndrome

Lentigines, Electrocardiographic Conduction Abnormalities, Ocular Hypertelorism, Pulmonic Stenosis, Abnormal Genitalia, Retardation Of Growth, Deafnes

Diffuse Lentiginosis

Nsml

Familial Multiple Lentigines Syndrome

Alopecia-Epilepsy-Intellectual Disability Syndrome, Moynahan Type

Progressive Cardiomyopathic Lentiginosis Syndrome

Alopecia Epilepsy Oligophrenia Syndrome Of Moynahan

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PPP1CB RGD RGD:3376
Canis familiaris PPP1CB VGNC VGNC:44875
Macaca mulatta PPP1CB VGNC VGNC:106197
Felis catus PPP1CB VGNC VGNC:68998
Mus musculus PPP1CB MGD MGI:104871
Bos taurus PPP1CB VGNC VGNC:33220
Others PPP1CB NCBI