SLC26A8 - solute carrier family 26 member 8 Gene

Homo sapiens

Also known as TAT1; SPGF3

Gene ID: 116369 | Gene type: protein coding

About SLC26A8

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:35,943,516-36,024,641 (from NCBI)

This gene has 8 transcripts (splice variants), 111 orthologues, 9 paralogues and is associated with 2 phenotypes. Restricted expression toward testis (RPKM 27.9).

Summary

This gene encodes a member of the SLC26 gene family of anion transporters. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. The expression of this gene appears to be restricted to spermatocytes. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2010]

SLC26A8 Products(3)

mRNA	Protein	Name
NM_001193476.2	NP_001180405.1	testis anion transporter 1 isoform a
NM_052961.4	NP_443193.1	testis anion transporter 1 isoform a
NM_138718.3	NP_619732.2	testis anion transporter 1 isoform b

SLC26A8 Protein Structure

Sulfate_transp

STAS

0
200
400
600
800
970 a.a.

Protein Preferred Names

Protein Names

testis anion transporter 1

anion transporter/exchanger-8

Related Diseases

Diseases

Alias

Spermatogenic Failure 3

SPGF3

Azoospermia, Nonobstructive

Non-Syndromic Male Infertility Due To Sperm Motility Disorder

Non-Syndromic Male Infertility Due Asthenozoospermia

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Diastrophic Dysplasia

Diastrophic Dwarfism	DTD
Dd	Diastrophic Dysplasia, Broad Bone-Platyspondylic Variant
Dysplasia, Diastrophic	Diastrophic Dysplasia Variant

Infertility

Pendred Syndrome

Goiter-Deafness Syndrome	Deafness With Goiter
PDS	Thyroid Dyshormonogenesis 2b
Tdh2b	Autosomal Recessive Sensorineural Hearing Impairment And Goiter
Pendred'S Syndrome	Thyroid Hormonogenesis, Genetic Defect In, 2b
Hypothyroidism, Congenital, Due To Dyshormonogenesis, 2b	Congenital Hypothyroidism Due To Dyshormonogenesis 2b
Genetic Defect In Thyroid Hormonogenesis 2b	Autosomal Recessive Sensorineural Hearing Impairment, Enlarged Vestibular Aqueduct, And Goiter
Goiter-Hearing Loss Syndrome	Goitre-Deafness Syndrome
Goitre Deafness

Atelosteogenesis

Atelosteogenesis, Type 1

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Osteochondrodysplasia

Skeletal Dysplasia	Chondrodystrophy
Congenital Anomaly Of Cartilage	Osteochondrodysplasias
Cartilage Development Disorder	Osteochondrodysplasia Syndrome
Dysplasia, Skeletal	Mucopolysaccharidosis Iv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13142	SLC26A8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC26A8	RGD	RGD:1308898
Mus musculus	SLC26A8	MGD	MGI:2385046
Bos taurus	SLC26A8	VGNC	VGNC:34783
Macaca mulatta	SLC26A8	VGNC	VGNC:77479
Felis catus	SLC26A8	VGNC	VGNC:65286
Canis familiaris	SLC26A8	VGNC	VGNC:46327

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