RACGAP1 - Rac GTPase activating protein 1 Gene

Homo sapiens

Also known as CYK4; CDAN3B; ID-GAP; HsCYK-4; MgcRacGAP

Gene ID: 29127 | Gene type: protein coding

About RACGAP1

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:49,989,162-50,033,440 (from NCBI)

This gene has 28 transcripts (splice variants) and 269 orthologues. Broad expression in testis (RPKM 17.3), bone marrow (RPKM 8.3) and 20 other tissues.

Summary

This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on chromosome 12. [provided by RefSeq, Feb 2016]

RACGAP1 Products(12)

mRNA	Protein	Name
NM_001126103.3	NP_001119575.1	rac GTPase-activating protein 1 isoform a
NM_001126104.3	NP_001119576.1	rac GTPase-activating protein 1 isoform a
NM_001319999.2	NP_001306928.1	rac GTPase-activating protein 1 isoform a
NM_001320000.2	NP_001306929.1	rac GTPase-activating protein 1 isoform a
NM_001320001.2	NP_001306930.1	rac GTPase-activating protein 1 isoform a
NM_001320002.2	NP_001306931.1	rac GTPase-activating protein 1 isoform a
NM_001320003.2	NP_001306932.1	rac GTPase-activating protein 1 isoform a
NM_001320004.2	NP_001306933.1	rac GTPase-activating protein 1 isoform a
NM_001320005.2	NP_001306934.1	rac GTPase-activating protein 1 isoform b
NM_001320006.2	NP_001306935.1	rac GTPase-activating protein 1 isoform c
NM_001320007.2	NP_001306936.1	rac GTPase-activating protein 1 isoform d
NM_013277.5	NP_037409.2	rac GTPase-activating protein 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	10979956	GOA
enables GTPase activator activity	IMP IMP: Inferred from mutant phenotype	15642749	GOA
enables alpha-tubulin binding	IDA IDA: Inferred from direct assay	11085985	GOA
enables beta-tubulin binding	IDA IDA: Inferred from direct assay	11085985	GOA
enables gamma-tubulin binding	IDA IDA: Inferred from direct assay	11085985	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	11782313	GOA
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA IDA: Inferred from direct assay	23235882	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11278976	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	19468302	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	11782313	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in actomyosin contractile ring assembly	IMP IMP: Inferred from mutant phenotype	16129829	GOA
involved in erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	34818416	GOA
involved in mitotic cytokinesis	IDA IDA: Inferred from direct assay	11085985	GOA
involved in mitotic cytokinesis	IMP IMP: Inferred from mutant phenotype	16236794	GOA
involved in mitotic spindle midzone assembly	IDA IDA: Inferred from direct assay	16103226	GOA
involved in positive regulation of cytokinesis	IDA IDA: Inferred from direct assay	16103226	GOA
involved in positive regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	11782313	GOA
involved in regulation of attachment of spindle microtubules to kinetochore	IMP IMP: Inferred from mutant phenotype	15642749	GOA
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	12590651	GOA
involved in sulfate transmembrane transport	IDA IDA: Inferred from direct assay	11278976	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of centralspindlin complex	IDA IDA: Inferred from direct assay	11782313	GOA
located in cleavage furrow	IDA IDA: Inferred from direct assay	16103226	GOA
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	23235882	GOA
located in midbody	IDA IDA: Inferred from direct assay	11782313	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	16103226	GOA
located in mitotic spindle	IMP IMP: Inferred from mutant phenotype	15642749	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11085985	GOA
located in spindle	IDA IDA: Inferred from direct assay	18445686	GOA
located in spindle midzone	IDA IDA: Inferred from direct assay	19468302	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RACGAP1 Protein Structure

C1_1

RhoGAP

0
100
200
300
400
500
632 a.a.

Protein Preferred Names

Protein Names

rac GTPase-activating protein 1

male germ cell RacGap

RACGAP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RACGAP1	Q9H0H5	ECT2	Homo sapiens	Q9H8V3	Anti Bait CoIP	18201571
Intra	RACGAP1	Q9H0H5	ECT2	Homo sapiens	Q9H8V3	ITC	25068414
Intra	RACGAP1	Q9H0H5	ECT2	Homo sapiens	Q9H8V3	Anti Bait CoIP	19468302
Intra	RACGAP1	Q9H0H5	SLC26A8	Homo sapiens	Q96RN1	Pull Down	11278976
Intra	RACGAP1	Q9H0H5	KIF23	Homo sapiens	Q02241	Anti Tag CoIP	35271311
Intra	RACGAP1	Q9H0H5	KIF23	Homo sapiens	Q02241	IF	11782313
Intra	RACGAP1	Q9H0H5	KIF23	Homo sapiens	Q02241	Anti Tag CoIP	26496610
Intra	RACGAP1	Q9H0H5	KIF23	Homo sapiens	Q02241	Anti Tag CoIP	33961781
Intra	RACGAP1	Q9H0H5	KIF23	Homo sapiens	Q02241	Anti Tag CoIP	32203420
Intra	RACGAP1	Q9H0H5	KIF23	Homo sapiens	Q02241	Anti Bait CoIP	11782313
Intra	RACGAP1	Q9H0H5	MORF4L1	Homo sapiens	Q9UBU8	Y2H Prey Pooling	25416956
Intra	RACGAP1	Q9H0H5	PLK1	Homo sapiens	P53350	Anti Bait CoIP	19468302
Intra	RACGAP1	Q9H0H5	CTNNA1	Homo sapiens	P35221	Anti Bait CoIP	22750944
Intra	RACGAP1	Q9H0H5	TRAF3IP3	Homo sapiens	Q9Y228	Validated Y2H	32296183
Intra	RACGAP1	Q9H0H5	RAB11FIP3	Homo sapiens	O75154	Competition Binding	18511905

Cross: Cross-species interaction Intra: Intraspecies interaction

RACGAP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83136	RACGAP1 Antibody (YA2881)	WB, IHC-P, ICC/IF	Human

Related Diseases

Diseases

Alias

Anemia, Congenital Dyserythropoietic, Type Iiib, Autosomal Recessive

CDAN3B	Cda, Type Iiib
Anemia, Congenital Dyserythropoietic, 3b, Autosomal Recessive

Cataract 36

CTRCT36	Catc4
Autosomal Recessive Congenital Cataract 4	Cataract, Autosomal Recessive Congenital 4
Cataract, Type 36

Anemia, Congenital Dyserythropoietic, Type Iiia

Congenital Dyserythropoietic Anemia, Type Iii	Cdan3
Congenital Dyserythropoietic Anemia Type Iii	Cda Iii
Congenital Dyserythropoietic Anemia Type 3	CDAN3A
Dyserythropoietic Anemia, Congenital, Type Iiia	Cda, Type Iiia
Anemia, Congenital Dyserythropoietic, Type Iii	Anemia With Multinucleated Erythroblasts
Cda Type 3	Cda Type Iii
Dyserythropoietic Anemia, Congenital Type 3	Cda, Type Iii
Erythroreticulosis, Hereditary Benign	Anaemia With Multinucleated Erythroblasts
Congenital Dyserythropoietic Anaemia Type 3	Congenital Dyserythropoietic Anaemia Type Iii
Hereditary Benign Erythroreticulosis	Anemia, Congenital Dyserythropoietic, 3a
Anemia With Multinucleated Erythroblasts Erythroreticulosis, Hereditary Benign

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Uterine Body Mixed Cancer

Malignant Mixed Tumor Of Corpus Uteri

Malignant Mixed Tumor, Not Otherwise Specified

Uterine Carcinosarcoma

Carcinosarcoma Of The Corpus Uteri	Mixed Mullerian Sarcoma Of Uterus
Malignant Mixed Müllerian Tumor Of The Corpus Uteri	Malignant Mixed Müllerian Tumor Of Corpus Uteri
Mixed Müllerian Cancer Of Corpus Uteri	Malignant Mixed Mullerian Tumor Of The Corpus Uteri
Mixed Mullerian Cancer Of Corpus Uteri	Uterine Corpus Carcinosarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11594	RACGAP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RACGAP1	VGNC	VGNC:33675
Macaca mulatta	RACGAP1	VGNC	VGNC:100098
Felis catus	RACGAP1	VGNC	VGNC:69210
Rattus norvegicus	RACGAP1	RGD	RGD:1305912
Canis familiaris	RACGAP1	VGNC	VGNC:45308
Mus musculus	RACGAP1	MGD	MGI:1349423

Name
Email *

	Sorry, but the email address you supplied was invalid.