Kidins220 - kinase D-interacting substrate 220 Gene

Rattus norvegicus

Also known as ARMS

Gene ID: 116478 | Gene type: protein coding

About Kidins220

Summary

Enables PDZ domain binding activity; protein kinase binding activity; and protein kinase regulator activity. Involved in nerve growth factor signaling pathway and positive regulation of neuron projection development. Located in late endosome. Part of protein-containing complex. Orthologous to human KIDINS220 (kinase D interacting substrate 220). [provided by Alliance of Genome Resources, Apr 2022]

Kidins220 Products(1)

mRNA	Protein	Name
NM_053795.2	NP_446247.2	kinase D-interacting substrate of 220 kDa

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IDA IDA: Inferred from direct assay	17724123	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16284401	RGD
enables protein kinase binding	IDA IDA: Inferred from direct assay	11150334	RGD
enables protein kinase regulator activity	IDA IDA: Inferred from direct assay	11150334	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to nerve growth factor stimulus	IDA IDA: Inferred from direct assay	17724123	RGD
involved in nerve growth factor signaling pathway	IDA IDA: Inferred from direct assay	17724123	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	17724123	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	20547223	RGD
located in late endosome	IDA IDA: Inferred from direct assay	17724123	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	20547223	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	17724123	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

kinase D-interacting substrate of 220 kDa

ankyrin repeat-rich membrane-spanning protein	kinase D-interacting substance 220
kinase D-interacting substance of 220 kDa

Kidins220 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Kidins220	Q9EQG6	CRKL	Homo sapiens	P46109	Pull Down	16284401

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07254	KIDINS220 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kidins220	NCBI	NCBI:57498

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