CRKL - CRK like proto-oncogene, adaptor protein Gene

Homo sapiens

Gene ID: 1399 | Gene type: protein coding

About CRKL

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:20,917,407-20,953,747 (from NCBI)

This gene has 2 transcripts (splice variants), 211 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 22.4), bone marrow (RPKM 22.0) and 25 other tissues.

Summary

This gene encodes a protein kinase containing SH2 and SH3 (Src homology) domains which has been shown to activate the Ras and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the Bcr-Abl tyrosine kinase, plays a role in fibroblast transformation by Bcr-Abl, and may be oncogenic.[provided by RefSeq, Jan 2009]

CRKL Products(1)

mRNA	Protein	Name
NM_005207.4	NP_005198.1	crk-like protein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IDA IDA: Inferred from direct assay	29581031	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17161365	GOA
enables phosphotyrosine residue binding	IPI IPI: Inferred from physical interaction	20624904	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8626543	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to transforming growth factor beta stimulus	IMP IMP: Inferred from mutant phenotype	23959425	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23959425	GOA
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	23959425	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	23959425	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	25540073	GOA
involved in positive regulation of glial cell migration	IMP IMP: Inferred from mutant phenotype	23959425	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	23959425	GOA
involved in positive regulation of substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	19004829	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRKL Protein Structure

SH2

SH3_1

SH3_2

0
100
200
303 a.a.

Protein Preferred Names

Protein Names

crk-like protein

v-crk avian sarcoma virus CT10 oncogene homolog-like

CRKL Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CRKL	P46109	FLT1	Homo sapiens	P17948	Anti Tag CoIP	23397142
Intra	CRKL	P46109	FLT1	Homo sapiens	P17948	PLA	23397142
Cross	CRKL	P46109	Kcnma1	Mus musculus	Q08460	Anti Bait CoIP	17065230
Intra	CRKL	P46109	BLK	Homo sapiens	P51451	Validated Y2H	32296183
Intra	CRKL	P46109	PDGFRA	Homo sapiens	P16234	CoIP	9546424
Intra	CRKL	P46109	PDGFRA	Homo sapiens	P16234	PLA	25241761
Intra	CRKL	P46109	PDGFRA	Homo sapiens	P16234	Enzymatic Study	9546424
Intra	CRKL	P46109	EGFR	Homo sapiens	P00533	Ub Reconstruction	24658140
Intra	CRKL	P46109	PSMC6	Homo sapiens	P62333	Validated Y2H	32296183
Intra	CRKL	P46109	ABL1	Homo sapiens	P00519	Anti Tag CoIP	33961781
Intra	CRKL	P46109	ABL1	Homo sapiens	P00519	Anti Bait CoIP	16443220
Intra	CRKL	P46109	ABL1	Homo sapiens	P00519	Pull Down	16443220
Intra	CRKL	P46109	GAB1	Homo sapiens	Q13480	PLA	25241761
Intra	CRKL	P46109	GAB1	Homo sapiens	Q13480	FPS	24728074
Intra	CRKL	P46109	GAB1	Homo sapiens	Q13480	PLA	23397142
Intra	CRKL	P46109	CBL	Homo sapiens	P22681	Anti Tag CoIP	33961781
Intra	CRKL	P46109	CBL	Homo sapiens	P22681	CoIP	8662998
Intra	CRKL	P46109	CBL	Homo sapiens	P22681	Y2H Array	25814554
Intra	CRKL	P46109	CBL	Homo sapiens	P22681	Anti Bait CoIP	16982329
Intra	CRKL	P46109	ITGB1	Homo sapiens	P05556	Anti Bait CoIP	19168626
Intra	CRKL	P46109	USP53	Homo sapiens	Q70EK8	Validated Y2H	32296183
Intra	CRKL	P46109	CBLB	Homo sapiens	Q13191	CoIP	10022120
Intra	CRKL	P46109	CBLB	Homo sapiens	Q13191	Validated Y2H	25814554
Intra	CRKL	P46109	DCBLD2	Homo sapiens	Q96PD2	Pull Down	23770091
Intra	CRKL	P46109	MAP4K1	Homo sapiens	Q92918	Pull Down	9788432
Intra	CRKL	P46109	MAP4K1	Homo sapiens	Q92918	CoIP	9788432
Intra	CRKL	P46109	CRKL	Homo sapiens	P46109	X-Ray Diffraction	17161365
Intra	CRKL	P46109	CRKL	Homo sapiens	P46109	Comigration in SDS	17161365
Intra	CRKL	P46109	RAPGEF1	Homo sapiens	Q13905	Anti Tag CoIP	26496610
Intra	CRKL	P46109	RAPGEF1	Homo sapiens	Q13905	Pull Down	16443220
Cross	CRKL	P46109	Kidins220	Rattus norvegicus	Q9EQG6	Pull Down	16284401

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Chromosome 22q11.2 Deletion Syndrome, Distal

22q11.2 Deletion Syndrome	Autosomal Dominant Opitz G/Bbb Syndrome
Catch22	Cayler Cardiofacial Syndrome
Conotruncal Anomaly Face Syndrome	Digeorge Syndrome
Sedlackova Syndrome	Shprintzen Syndrome
Velocardiofacial Syndrome	22q11.2 Distal Deletion Syndrome
Distal 22q11.2 Microdeletion Syndrome	22q11.2ds
Vcfs	Velo-Cardio-Facial Syndrome
Distal Chromosome 22q11.2 Deletion Syndrome	Chromosome 22q11.2 Deletion Syndrome Distal
Chromosome 22q11.2 Deletion Syndrome	Deletion 22q11.2 Syndrome
22q11ds	Catch 22
Digeorge Sequence	Microdeletion 22q11.2
Monosomy 22q11	Takao Syndrome
Distal Del(22)(Q11.2)	Distal Monosomy 22q11.2
Catch 22 Syndrome	Chromosome Deletion Syndrome 22q11.2, Distal

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

Digeorge Syndrome

Chromosome 22q11.2 Deletion Syndrome	DGS
Hypoplasia Of Thymus And Parathyroids	Third And Fourth Pharyngeal Pouch Syndrome
22q11.2 Deletion Syndrome	Digeorge Sequence
Digeorge'S Syndrome	Pharyngeal Pouch Syndrome
Di-George Syndrome	Shprintzen Syndrome

T-Cell Immunodeficiency With Thymic Aplasia

Nezelof Syndrome	T-Lymphocyte Deficiency
TIDTA	Immune Defect Due To Absence Of Thymus
Thymic Aplasia	Nezelof'S Syndrome
Thymic Dysplasia With Normal Immunoglobulins	Thymic Aplasia Syndrome
T-Lymphocyte Immunodeficiency

Bladder Exstrophy-Epispadias-Cloacal Exstrophy Complex

Exstrophy-Epispadias Complex	Bladder Exstrophy-Epispadias-Cloacal Extrophy Complex
Beec	Eec
Exstrophy Of The Bladder	Bladder Exstrophy
Bladder Exstrophy And Epispadias Complex

Velocardiofacial Syndrome

Shprintzen Syndrome	VCFS
Chromosome 22q11.2 Deletion Syndrome	Vcf Syndrome
Shprintzen Vcf Syndrome	Vcf-Velocardiofacial Syndrome
Velo-Cardio-Facial Syndrome	Digeorge Syndrome
22q11 Deletion Syndrome	Conotruncal Anomaly Face Syndrome

Chromosome 22q11.2 Duplication Syndrome

Chromosome 22q11.2 Microduplication Syndrome	22q11.2 Microduplication Syndrome
22q11.2 Duplication Syndrome	Duplication 22q11.2
Trisomy 22q11.2	22q11.2 Duplication
Dup(22)(Q11)

Chromosomal Deletion Syndrome

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia	ALL
Acute Lymphocytic Leukemia	Leukemia, Acute Lymphocytic, Susceptibility To, 1
Acute Lymphoblastic Leukaemia	Precursor Lymphoblastic Lymphoma/Leukemia
Precursor Lymphoid Neoplasm	Leukemia, Acute Lymphoblastic, Susceptibility To
B-Cell Acute Lymphoblastic Leukemia	Leukemia, Acute Lymphocytic 1
Acute Lymphocytic Leukaemia	Acute Lymphoblastic Leukemia/Lymphoma
All1	Childhood Acute Lymphoblastic Leukemia
Leukemia Acute Lymphoblastic 1	Leukemia Acute Lymphoblastic B-Hyperdiploid
Leukemia Acute Lymphocytic	Leukemia Acute Lymphocytic 1
Leukemia B-Cell Acute Lymphoblastic	Leukemia T-Cell Acute Lymphoblastic
Leukemia, Acute Lymphoblastic, 3	ALL3
Lymphoblastic Leukemia Acute	Leukemia, Acute, Lymphoblastic
Precursor Cell Lymphoblastic Leukemia Lymphoma	Leukemia, Lymphocytic, Acute, L1
Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Double Outlet Right Ventricle

Double Outlet Right Ventricle With Subpulmonary Ventricular Septal Defect	Taussig-Bing Syndrome
Dextrotransposition Of Aorta	Taussig-Bing Syndrome Or Defect
Dorv	Dorv With Subpulmonary Vsd
Dorv-Tga	Double Outlet Right Ventricle With Transposition Of The Great Arteries
Double Outlet Right Ventricle With Subpulmonary Interventricular Communication, Transposition Type	Taussig-Bing Heart
Taussig-Bing Malformation	Taussig-Bing Complex
Taussig-Bing Defect	Taussig-Bing
Double Outlet Right Ventricle With Remote Ventricular Septal Defect	Double Outlet Right Ventricle With Uncommitted Ventricular Septal Defect
Double Outlet Right Ventricle With Non-Committed Interventricular Communication	Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication Without Pulmonary Stenosis
Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication And Pulmonary Stenosis

Tetralogy Of Fallot

TOF	Fallot Tetralogy
Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle	Tetrad Of Fallot
Fallot Tetrad	Fallot Disease
Fallot Complex	Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy
Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle	Interventricular Septal Defect, In Tetralogy Of Fallot
Ventricular Septal Defect With Obstructed Right Ventricular Outflow	Tof - [Tetralogy Of Fallot]
Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]	Pulmonary Atresia, Ventricular Septal Defect And Mapcas
Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome	Deletion 1p36
Monosomy 1p36	Subtelomeric 1p36 Deletion
Monosomy 1p36 Syndrome	Distal Monosomy 1p36
Del(1)(P36)	Deletion 1pter
Monosomy 1pter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125090	PHA-680626		/	Unkown
HY-RS03185	CRKL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-164469	CHMFL-48	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CRKL	VGNC	VGNC:53897
Mus musculus	CRKL	MGD	MGI:104686
Rattus norvegicus	CRKL	RGD	RGD:1308531
Felis catus	CRKL	VGNC	VGNC:61182
Canis familiaris	CRKL	VGNC	VGNC:39619
Others	CRKL	NCBI

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