Bak1 - BCL2-antagonist/killer 1 Gene

Rattus norvegicus

Also known as Bak

Gene ID: 116502 | Gene type: protein coding

About Bak1

Primary_assembly 20: 5,100,480-5,109,264 reverse strand.mRatBN7.2:CM026993.1

This gene has 1 transcript (splice variant), 135 orthologues, 13 paralogues and is associated with 15 phenotypes. Biased expression in Thymus (RPKM 137.4), Spleen (RPKM 16.9) and 9 other tissues.

Summary

Enables several functions, including chaperone binding activity; heat shock protein binding activity; and identical protein binding activity. Involved in several processes, including animal organ development; positive regulation of release of cytochrome c from mitochondria; and release of cytochrome c from mitochondria. Located in cytosol; membrane; and mitochondrion. Biomarker of intermittent claudication. Human ortholog(s) of this gene implicated in ataxia telangiectasia and cervix carcinoma. Orthologous to human BAK1 (BCL2 antagonist/killer 1). [provided by Alliance of Genome Resources, Apr 2022]

Bak1 Products(1)

mRNA	Protein	Name
NM_053812.2	NP_446264.1	bcl-2 homologous antagonist/killer

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables BH domain binding	IPI IPI: Inferred from physical interaction	9356461	RGD
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	12070120	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	12454021	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15004018	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	9356461	RGD
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	12070120	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	11232245	RGD
involved in endocrine pancreas development	IEP IEP: Inferred from expression pattern	11000281	RGD
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18349538	RGD
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18349538	RGD
involved in positive regulation of release of cytochrome c from mitochondria	IMP IMP: Inferred from mutant phenotype	12485416	RGD
involved in release of cytochrome c from mitochondria	IMP IMP: Inferred from mutant phenotype	18252800	RGD
involved in response to UV-C	IEP IEP: Inferred from expression pattern	19520675	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	20028358	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	19143845	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	18817839	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	15875735	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bak1 Protein Structure

Bcl-2_like

0
100
209 a.a.

Protein Preferred Names

Protein Names

bcl-2 homologous antagonist/killer

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01357	BAK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01358	Bak1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01359	Bak1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-129461	Dibenzyl trisulfide	Inducer	/	Unkown
HY-136999	7-O-Methyleucomol		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bak1	NCBI	NCBI:578

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