BAK1 - BCL2 antagonist/killer 1 Gene

Homo sapiens

Also known as BAK; CDN1; BCL2L7; BAK-LIKE

Gene ID: 578 | Gene type: protein coding

About BAK1

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:33,572,552-33,580,276 (from NCBI)

This gene has 2 transcripts (splice variants), 129 orthologues and 8 paralogues. Ubiquitous expression in duodenum (RPKM 20.6), small intestine (RPKM 16.4) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce Apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]

BAK1 Products(5)

mRNA	Protein	Name
NM_001188.4	NP_001179.1	bcl-2 homologous antagonist/killer
XM_047419196.1	XP_047275152.1	bcl-2 homologous antagonist/killer isoform X3
XM_047419194.1	XP_047275150.1	bcl-2 homologous antagonist/killer isoform X2
XM_011514780.2	XP_011513082.1	bcl-2 homologous antagonist/killer isoform X3
XM_011514779.4	XP_011513081.1	bcl-2 homologous antagonist/killer isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	10950869	GOA
enables porin activity	IDA IDA: Inferred from direct assay	22006182	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9027312	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	10837489	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	23028632	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	25296756	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	18387192	GOA
involved in apoptotic process	IDA IDA: Inferred from direct assay	23028632	GOA
involved in apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	15901672	GOA
involved in cellular response to UV	IMP IMP: Inferred from mutant phenotype	15901672	GOA
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19593445	GOA
involved in establishment or maintenance of transmembrane electrochemical gradient	IDA IDA: Inferred from direct assay	9843949	GOA
involved in intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	22006182	GOA
involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IDA IDA: Inferred from direct assay	15901672	GOA
involved in negative regulation of release of cytochrome c from mitochondria	IDA IDA: Inferred from direct assay	15901672	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17289999	GOA
involved in positive regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	9111042	GOA
involved in positive regulation of proteolysis	IDA IDA: Inferred from direct assay	18387192	GOA
involved in regulation of mitochondrial membrane permeability	IDA IDA: Inferred from direct assay	9843949	GOA
involved in regulation of mitochondrial membrane potential	IDA IDA: Inferred from direct assay	9843949	GOA
involved in release of cytochrome c from mitochondria	IDA IDA: Inferred from direct assay	9843949	GOA
involved in release of cytochrome c from mitochondria	IGI IGI: Inferred from genetic interaction	21041309	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of BAK complex	IDA IDA: Inferred from direct assay	10950869	GOA
part of BAK complex	IPI IPI: Inferred from physical interaction	32929280	GOA
part of Bcl-2 family protein complex	IDA IDA: Inferred from direct assay	21041309	GOA
part of Bcl-2 family protein complex	IPI IPI: Inferred from physical interaction	22515821	GOA
is active in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	22006182	GOA
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	29531808	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	9843949	GOA
part of pore complex	IDA IDA: Inferred from direct assay	9843949	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BAK1 Protein Structure

Bcl-2

0
100
211 a.a.

Protein Preferred Names

Protein Names

bcl-2 homologous antagonist/killer

BCL2-like 7 protein	apoptosis regulator BAK
bcl-2-like protein 7	bcl2-L-7
pro-apoptotic protein BAK

Related Diseases

Diseases

Alias

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Protection Against	Lung Cancer, Susceptibility To
Adenocarcinoma Of Lung, Somatic	Nonsmall Cell Lung Cancer
Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Follicular Lymphoma

Lymphoma, Follicular	Lymphoma Follicular
Brill-Symmers' Disease	Large Cell Follicular Non-Hodgkin Lymphoma
Diffuse Follicle Centre Lymphoma	Diffuse Follicular Lymphoma Nos
Follicular Nodular Non-Hodgkin Lymphoma, Unspecified	Follicular Large Cell Cleaved Or Noncleaved Lymphoma
Large Cell Follicular Noncleaved Lymphoma	Follicular Lymphoma With Or Without Diffuse Areas
Histiocytic Follicular Lymphoma	Histiocytic Nodular Lymphoma
Histiocytic Nodular Malignant Lymphoma	Large Cell Follicular Lymphoma
Large Cell Noncleaved Follicular Lymphoma	Large Cell Noncleaved Follicular Malignant Lymphoma
Nodular Reticulum Cell Sarcoma	Noncleaved Follicular Lymphoma

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Keratoacanthoma

Ka - [Keratoacanthoma]

Well-Differentiated Squamous Cell Carcinoma

Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism	Undescended Testicle
Undescended Testis	Cryptorchism
Undescended Testicles	CRYPTO
Impaired Testicular Descent	Cryptosporidiosis
Retained Testis	Unilateral Cryptorchidism
Unilateral Undescended Testis	Nondescent Unilateral Testicle
Unilateral Cryptorchism	Ectopic Testis, Unilateral
Bilateral Cryptorchidism	Bilateral Cryptorchism
Bilateral Nondescent Testicle	Bilateral Undescended Testes
Bilateral Ectopic Testes

Childhood Germ Cell Cancer

Pediatric Germ Cell Tumor	Paediatric Germ Cell Cancer
Paediatric Germ Cell Neoplasm	Pediatric Germ Cell Cancer
Pediatric Germ Cell Neoplasm

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma	Lymphoma, Non-Hodgkin
NHL	Lymphoma, Non-Hodgkin, Somatic
Lymphoma, Follicular, Somatic	Familial Non-Hodgkin Lymphoma
Lymphoma Non-Hodgkins	Follicular Lymphoma, Somatic
Lymphosarcoma	Non-Hodgkins Lymphoma

Absolute Glaucoma

Blind Hypertensive Eye

Glaucoma Absolute

Pancreatic Cancer

Pancreatic Carcinoma	Familial Pancreatic Carcinoma
Pancreatic Neoplasm	Carcinoma Of Pancreas
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Pancreatic Carcinoma, Somatic	Pancreatic Cancer, Somatic
Ca Body Of Pancreas	Ca Head Of Pancreas
Ca Tail Of Pancreas	Malignant Neoplasm Of Body Of Pancreas
Malignant Neoplasm Of Head Of Pancreas	Malignant Neoplasm Of Tail Of Pancreas
Pancreas Neoplasm	Exocrine Cancer
Exocrine Pancreas Carcinoma	Hereditary Pancreatic Cancer
Hereditary Pancreatic Carcinoma	PNCA
Cancer Of The Pancreas	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Myeloma, Multiple

Multiple Myeloma	Kahler Disease
Myelomatosis	Plasma Cell Myeloma
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Multiple Myeloma, Susceptibility To	Myeloma - Multiple
Kahler'S Disease	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Breast Disease

Breast Diseases

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01357	BAK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01358	Bak1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01359	Bak1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-129461	Dibenzyl trisulfide	Inducer	/	Unkown
HY-136999	7-O-Methyleucomol		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	BAK1	VGNC	VGNC:70224
Rattus norvegicus	BAK1	RGD	RGD:621635
Mus musculus	BAK1	MGD	MGI:1097161
Felis catus	BAK1	VGNC	VGNC:102386
Bos taurus	BAK1	VGNC	VGNC:26416
Canis familiaris	BAK1	VGNC	VGNC:38375
Others	BAK1	NCBI

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