HSPA12B - heat shock protein family A (Hsp70) member 12B Gene

Homo sapiens

Also known as C20orf60

Gene ID: 116835 | Gene type: protein coding

About HSPA12B

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:3,732,685-3,753,111 (from NCBI)

This gene has 2 transcripts (splice variants), 193 orthologues and 4 paralogues. Broad expression in fat (RPKM 15.5), spleen (RPKM 11.6) and 19 other tissues.

Summary

The protein encoded by this gene contains an atypical heat shock protein 70 (HSP70) ATPase domain and is therefore a distant member of the mammalian HSP70 family. This gene may be involved in susceptibility to atherosclerosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

HSPA12B Products(3)

mRNA	Protein	Name
NM_001197327.2	NP_001184256.1	heat shock 70 kDa protein 12B isoform 2
NM_001318322.2	NP_001305251.1	heat shock 70 kDa protein 12B isoform 3
NM_052970.5	NP_443202.3	heat shock 70 kDa protein 12B isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

heat shock 70 kDa protein 12B

HSPA12B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HSPA12B	Q96MM6	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	HSPA12B	Q96MM6	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	HSPA12B	Q96MM6	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	HSPA12B	Q96MM6	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	HSPA12B	Q96MM6	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	HSPA12B	Q96MM6	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	HSPA12B	Q96MM6	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	HSPA12B	Q96MM6	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	HSPA12B	Q96MM6	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	HSPA12B	Q96MM6	HSPA12A	Homo sapiens	O43301	Y2H Array	32296183
Intra	HSPA12B	Q96MM6	HSPA12A	Homo sapiens	O43301	Y2H Prey Pooling	32296183
Intra	HSPA12B	Q96MM6	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	HSPA12B	Q96MM6	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	HSPA12B	Q96MM6	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	HSPA12B	Q96MM6	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	HSPA12B	Q96MM6	EFEMP2	Homo sapiens	O95967	Y2H Prey Pooling	32296183
Intra	HSPA12B	Q96MM6	EFEMP2	Homo sapiens	O95967	Y2H Array	32296183
Intra	HSPA12B	Q96MM6	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
Intra	HSPA12B	Q96MM6	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956
Intra	HSPA12B	Q96MM6	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	HSPA12B	Q96MM6	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	HSPA12B	Q96MM6	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06421	HSPA12B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HSPA12B	VGNC	VGNC:84531
Felis catus	HSPA12B	VGNC	VGNC:80114
Mus musculus	HSPA12B	MGD	MGI:1919880
Canis familiaris	HSPA12B	VGNC	VGNC:53543
Rattus norvegicus	HSPA12B	RGD	RGD:1312004

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