HSPA12A - heat shock protein family A (Hsp70) member 12A Gene

Homo sapiens

Gene ID: 259217 | Gene type: protein coding

About HSPA12A

Cytogenetic location: 10q25.3 Genomic coordinates (GRCh38): 10:116,671,192-116,850,747 (from NCBI)

This gene has 30 transcripts (splice variants), 204 orthologues and 4 paralogues. Broad expression in brain (RPKM 23.0), fat (RPKM 11.2) and 16 other tissues.

Summary

Predicted to enable ATP binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

HSPA12A Products(2)

mRNA	Protein	Name
NM_001330164.2	NP_001317093.1	heat shock 70 kDa protein 12A isoform 1
NM_025015.3	NP_079291.2	heat shock 70 kDa protein 12A isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	30679749	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

heat shock 70 kDa protein 12A

heat shock 70kD protein 12A

HSPA12A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HSPA12A	O43301	HSPA12B	Homo sapiens	Q96MM6	Anti Tag CoIP	33961781
Intra	HSPA12A	O43301	HSPA12B	Homo sapiens	Q96MM6	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

External Ear Disease

Diseases Of External Ear	Preauricular Cyst
Preauricular Sinus And Fistula	Preauricular Sinus Or Fistula

Otitis Externa

Swimmer'S Ear	Infective Otitis Externa
Acute Infective Otitis Externa

Leukoencephalopathy With Vanishing White Matter

Cree Leukoencephalopathy	Vanishing White Matter Disease
Ovarioleukodystrophy	Vanishing White Matter Leukodystrophy
Childhood Ataxia With Central Nervous System Hypomyelinization	Cach
Cach Syndrome	Myelinosis Centralis Diffusa
VWM	Cle
Childhood Ataxia With Central Nervous System Hypomyelination	Childhood Ataxia With Diffuse Central Nervous System Hypomyelination
Cach/Vwm	Cach/Vwm Syndrome
Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter	Cree Leukoencehalopathy
Late Infantile Cach Syndrome	Juvenile Or Adult Cach Syndrome
Congenital Or Early Infantile Cach Syndrome	Leukodystrophy With Vanishing White Matter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06420	HSPA12A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HSPA12A	VGNC	VGNC:52995
Macaca mulatta	HSPA12A	VGNC	VGNC:106059
Rattus norvegicus	HSPA12A	RGD	RGD:1305531
Mus musculus	HSPA12A	MGD	MGI:1920692
Bos taurus	HSPA12A	VGNC	VGNC:55956

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