1. Gene
  2. ARAP1 - ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 Gene

ARAP1 - ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 Gene

Homo sapiens

Also known as CENTD2; cnt-d2

Gene ID: 116985 | Gene type: protein coding

About ARAP1

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:72,685,069-72,752,408 (from NCBI)

This gene has 21 transcripts (splice variants), 210 orthologues and 28 paralogues. Ubiquitous expression in spleen (RPKM 32.0), appendix (RPKM 25.3) and 25 other tissues.

Summary

The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in Apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

ARAP1 Products(4)

mRNA Protein Name
NM_001040118.3 NP_001035207.1 arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform c
NM_001135190.2 NP_001128662.1 arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform d
NM_001369489.1 NP_001356418.1 arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform e
NM_015242.5 NP_056057.2 arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
11804590 GOA
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
IDA: Inferred from direct assay
11804589 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15607035 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of stress fiber assembly IMP
IMP: Inferred from mutant phenotype
11804590 GOA
involved in positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
11804590 GOA
involved in positive regulation of filopodium assembly IMP
IMP: Inferred from mutant phenotype
11804590 GOA
involved in regulation of cell shape IMP
IMP: Inferred from mutant phenotype
11804590 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
11804590 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARAP1 Protein Structure

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (10 - 66)

PH

PH: PH domain (328 - 418)

ArfGap

ArfGap: Putative GTPase activating protein for Arf (537 - 651)

PH

PH: PH domain (756 - 848)

RhoGAP

RhoGAP: RhoGAP domain (971 - 1118)

RA

RA: Ras association (RalGDS/AF-6) domain (1174 - 1260)

PH

PH: PH domain (1296 - 1390)

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  • 1450 a.a.
Protein Preferred Names Protein Names

arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containing protein 1

ARAP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ARAP1 Q96P48 XRCC6 Homo sapiens P12956 16169070
Cross
ARAP1 Q96P48 P27958-PRO_0000037576 Hepatitis C virus P27958-PRO_0000037576 15607035
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Wolfram Syndrome 2

WFS2

Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus ARAP1 VGNC VGNC:59862
Bos taurus ARAP1 VGNC VGNC:106641
Rattus norvegicus ARAP1 RGD RGD:1310385
Canis familiaris ARAP1 VGNC VGNC:38025
Mus musculus ARAP1 MGD MGI:1916960
Macaca mulatta ARAP1 VGNC VGNC:69844