SLC16A10 - solute carrier family 16 member 10 Gene

Homo sapiens

Also known as TAT1; MCT10; PRO0813

Gene ID: 117247 | Gene type: protein coding

About SLC16A10

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:111,087,503-111,231,194 (from NCBI)

This gene has 5 transcripts (splice variants), 247 orthologues and 13 paralogues. Broad expression in placenta (RPKM 4.2), skin (RPKM 2.5) and 19 other tissues.

Summary

SLC16A10 is a member of a family of plasma membrane amino acid transporters that mediate the Na(+)-independent transport of aromatic Amino acids across the plasma membrane.[supplied by OMIM, Apr 2004]

SLC16A10 Products(1)

mRNA	Protein	Name
NM_018593.5	NP_061063.2	monocarboxylate transporter 10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-phenylalanine transmembrane transporter activity	IDA IDA: Inferred from direct assay	11827462	GOA
enables L-tryptophan transmembrane transporter activity	IDA IDA: Inferred from direct assay	11827462	GOA
enables L-tyrosine transmembrane transporter activity	IDA IDA: Inferred from direct assay	11827462	GOA
enables aromatic amino acid transmembrane transporter activity	IDA IDA: Inferred from direct assay	11827462	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables thyroid hormone transmembrane transporter activity	IDA IDA: Inferred from direct assay	18337592	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in aromatic amino acid transport	IDA IDA: Inferred from direct assay	11827462	GOA
involved in thyroid hormone transport	IDA IDA: Inferred from direct assay	18337592	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	15918515	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18337592	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC16A10 Protein Structure

MFS_1

0
100
200
300
400
515 a.a.

Protein Preferred Names

Protein Names

monocarboxylate transporter 10

MCT 10

SLC16A10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLC16A10	Q8TF71	FUNDC2	Homo sapiens	Q9BWH2	Validated Y2H	32296183
Intra	SLC16A10	Q8TF71	INSIG2	Homo sapiens	Q9Y5U4	Validated Y2H	32296183
Intra	SLC16A10	Q8TF71	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Allan-Herndon-Dudley Syndrome

AHDS	Allan-Herndon Syndrome
Monocarboxylate Transporter 8 Deficiency	MCT8 DEFICIENCY
Mental Retardation, X-Linked, With Hypotonia	Triiodothyronine Resistance
T3 Resistance	Mental Retardation And Muscular Atrophy
Mct8-Specific Thyroid Hormone Cell-Membrane Transporter Deficiency	Intellectual Disability And Muscular Atrophy
Monocarboxylate Transporter-8 Deficiency	T3 Resisitence
Triiodothyronine Resistence	X-Linked Intellectual Disability With Hypotonia
Mct8 -Specific Thyroid Hormone Cell Transporter Deficiency	Monocarboxylate Transporter 8 Deficiency
X-Linked Intellectual Disability-Hypotonia Syndrome

Deafness, Autosomal Recessive 62

DFNB62	Autosomal Recessive Nonsyndromic Deafness 62
Autosomal Recessive Deafness 62

Euthyroid Sick Syndrome

Euthyroid Sick Syndromes	Sick-Euthyroid Syndrome
Ess - [Euthyroid Sick Syndrome]	Low-T3 Syndrome
Ntis - [Non-Thyroidal Illness Syndrome]	Tscitus - [Thyroid Allostasis In Critical Illness, Tumours, Uraemia And Starvation]

Congenital Hypothyroidism

Cretinism	Neonatal Hypothyroidism
Ch	Cht
Congenital Myxedema	Myxedema, Congenital
Endemic Cretinism	Congenital Iodine-Deficiency Syndrome
Fetal Iodine Deficiency Syndrome	Congenital Iodine-Deficiency Hypothyroidism Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13019	SLC16A10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLC16A10	VGNC	VGNC:46236
Bos taurus	SLC16A10	VGNC	VGNC:34684
Rattus norvegicus	SLC16A10	RGD	RGD:69197
Macaca mulatta	SLC16A10	VGNC	VGNC:103866
Mus musculus	SLC16A10	MGD	MGI:1919722

Name
Email *

	Sorry, but the email address you supplied was invalid.