2. Gene
  3. INSIG2 - insulin induced gene 2 Gene

INSIG2 - insulin induced gene 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as INSIG-2

Gene ID: 51141 | Gene type: protein coding

About INSIG2

Cytogenetic location: 2q14.1-q14.2 Genomic coordinates (GRCh38): 2:118,088,471-118,110,997 (from NCBI)

This gene has 7 transcripts (splice variants), 210 orthologues and 1 paralogue. Ubiquitous expression in liver (RPKM 12.3), lung (RPKM 10.5) and 25 other tissues.

Summary

The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. [provided by RefSeq, Jul 2008]

INSIG2 Products(6)

mRNA Protein Name
NM_001321329.2 NP_001308258.1 insulin-induced gene 2 protein isoform a
NM_001321330.2 NP_001308259.1 insulin-induced gene 2 protein isoform b
NM_001321331.2 NP_001308260.1 insulin-induced gene 2 protein isoform b
NM_001321332.2 NP_001308261.1 insulin-induced gene 2 protein isoform b
NM_001321333.2 NP_001308262.1 insulin-induced gene 2 protein isoform c
NM_016133.4 NP_057217.2 insulin-induced gene 2 protein isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables oxysterol binding IDA
IDA: Inferred from direct assay
17428920 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12242332 GOA
enables protein sequestering activity IDA
IDA: Inferred from direct assay
15899885 GOA
Biological Process GO Annotation Evidence Reference Source
involved in SREBP signaling pathway IDA
IDA: Inferred from direct assay
12242332 GOA
involved in SREBP-SCAP complex retention in endoplasmic reticulum IDA
IDA: Inferred from direct assay
15899885 GOA
involved in cholesterol biosynthetic process IDA
IDA: Inferred from direct assay
32322062 GOA
Cellular Component GO Annotation Evidence Reference Source
part of SREBP-SCAP-Insig complex IDA
IDA: Inferred from direct assay
12242332 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
32322062 GOA
is active in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
32322062 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INSIG2 Protein Structure

INSIG

INSIG: Insulin-induced protein (INSIG) (29 - 211)

  • 0
  • 100
  • 200
  • 225 a.a.
Protein Preferred Names Protein Names

insulin-induced gene 2 protein

INSIG2 membrane protein

INSIG2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
INSIG2 Q9Y5U4 VMA21 Homo sapiens Q3ZAQ7
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 VMA21 Homo sapiens Q3ZAQ7
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 NEMP1 Homo sapiens O14524-2
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 NEMP1 Homo sapiens O14524-2
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 AQP2 Homo sapiens P41181
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 AQP2 Homo sapiens P41181
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 SLC16A10 Homo sapiens Q8TF71
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 SLC16A10 Homo sapiens Q8TF71
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 TMEM52B Homo sapiens Q4KMG9
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 TMEM52B Homo sapiens Q4KMG9
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 CYBC1 Homo sapiens Q9BQA9
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 CYBC1 Homo sapiens Q9BQA9
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 LAPTM5 Homo sapiens Q13571
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 LAPTM5 Homo sapiens Q13571
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 GPR37L1 Homo sapiens O60883
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 GPR37L1 Homo sapiens O60883
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 RNF5 Homo sapiens Q99942
Validated Y2H
25416956
Intra
INSIG2 Q9Y5U4 RNF5 Homo sapiens Q99942
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 RNF5 Homo sapiens Q99942
Y2H Prey Pooling
25416956
Intra
INSIG2 Q9Y5U4 RNF5 Homo sapiens Q99942
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 ATP6V0B Homo sapiens Q99437
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 ATP6V0B Homo sapiens Q99437
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 IFNGR2 Homo sapiens P38484
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 IFNGR2 Homo sapiens P38484
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 PVR Homo sapiens P15151
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 PVR Homo sapiens P15151
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 TMEM45B Homo sapiens Q96B21
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 TMEM45B Homo sapiens Q96B21
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 STIM1 Homo sapiens Q13586
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 STIM1 Homo sapiens Q13586
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 PRLR Homo sapiens P16471
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 PRLR Homo sapiens P16471
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 CD40 Homo sapiens P25942
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 CD40 Homo sapiens P25942
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 MMGT1 Homo sapiens Q8N4V1
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 MMGT1 Homo sapiens Q8N4V1
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 BIK Homo sapiens Q13323
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 GOLM1 Homo sapiens Q8NBJ4
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 ABHD4 Homo sapiens Q8TB40
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 ABHD4 Homo sapiens Q8TB40
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 KIR2DL3 Homo sapiens P43628
Y2H Array
32296183
Intra
INSIG2 Q9Y5U4 KIR2DL3 Homo sapiens P43628
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
INSIG2 Q9Y5U4 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Leptin Deficiency Or Dysfunction

Morbid Obesity

Obesity Due To Congenital Leptin Deficiency

LEPD

Congenital Leptin Deficiency

Obesity, Morbid

Obesity, Morbid, Due To Leptin Deficiency

Severe Obesity

Obesity, Morbid, Nonsyndromic 1

Leptin Deficiency

Obesity, Severe, Due To Leptin Deficiency

Leptin

Morbid Obesity Due To Leptin Deficiency

Obesity Morbid

Leptin Dysfunction
Diabetes Mellitus

Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06838 INSIG2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta INSIG2 VGNC VGNC:73632
Bos taurus INSIG2 VGNC VGNC:30218
Rattus norvegicus INSIG2 RGD RGD:631417
Canis familiaris INSIG2 VGNC VGNC:42040
Mus musculus INSIG2 MGD MGI:1920249
Felis catus INSIG2 VGNC VGNC:62933