2. Gene
  3. TNFSF11 - TNF superfamily member 11 Gene

TNFSF11 - TNF superfamily member 11 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as ODF; OPGL; RANKL; TRANCE

Gene ID: 117516 | Gene type: protein coding

About TNFSF11

Primary_assembly 15: 53,673,877-53,705,445 reverse strand.mRatBN7.2:CM026988.1

This gene has 1 transcript (splice variant), 215 orthologues, 8 paralogues and is associated with 13 phenotypes. Biased expression in Thymus (RPKM 39.9), Spleen (RPKM 12.2) and 1 other tissue.

Summary

Predicted to enable cytokine activity; identical protein binding activity; and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including positive regulation of bone resorption; positive regulation of osteoclast differentiation; and response to immobilization stress. Predicted to be located in extracellular space and plasma membrane. Predicted to be integral component of membrane. Biomarker of mucopolysaccharidosis VI and myocarditis. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 2 and osteoporosis. Orthologous to human TNFSF11 (TNF Superfamily member 11). [provided by Alliance of Genome Resources, Apr 2022]

TNFSF11 Products(1)

mRNA Protein Name
NM_057149.2 NP_476490.2 tumor necrosis factor ligand superfamily member 11
Protein Preferred Names Protein Names

tumor necrosis factor ligand superfamily member 11

TNF-related activation-induced cytokine

osteoclast differentiation factor

osteoprotegerin ligand

receptor activator of nuclear factor kappa-B ligand

tumor necrosis factor (ligand) superfamily, member 11

tumor necrosis factor superfamily member 11

Related Agents

Approval
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9958 Denosumab Inhibitor 99.10% Unkown
Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P9958A Denosumab (anti-TNFSF11) 95.00% Phase 4
Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14819 TNFSF11 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14820 Tnfsf11 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14821 TNFSF11 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens TNFSF11 NCBI NCBI:8600
Macaca fascicularis TNFSF11 NCBI NCBI:102137946
Mus musculus TNFSF11 NCBI NCBI:21943