Apc - APC, WNT signaling pathway regulator Gene

Mus musculus

Also known as CC1; Min; mAPC

Gene ID: 11789 | Gene type: protein coding

About Apc

Chromosome 18: 34,353,977-34,455,605 forward strand.GRCm39:CM001011.3

This gene has 9 transcripts (splice variants), 169 orthologues, 1 paralogue and is associated with 121 phenotypes. Broad expression in frontal lobe adult (RPKM 29.9), CNS E18 (RPKM 22.5) and 18 other tissues.

Summary

Enables several functions, including beta-catenin binding activity; dynein complex binding activity; and Enzyme binding activity. Involved in Insulin Receptor signaling pathway; positive regulation of cold-induced thermogenesis; and positive regulation of protein localization to centrosome. Acts upstream of or within several processes, including animal organ development; regionalization; and regulation of microtubule polymerization or depolymerization. Located in several cellular components, including axonal growth cone; cell projection membrane; and microtubule Cytoskeleton. Part of Scrib-APC-beta-catenin complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system ganglion; and retina. Used to study breast cancer; familial adenomatous polyposis; gastrointestinal system Cancer (multiple); and reproductive organ Cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial Cancer (multiple); familial adenomatous polyposis 1; hereditary desmoid disease; and medulloblastoma. Orthologous to human APC (APC regulator of Wnt signaling pathway). [provided by Alliance of Genome Resources, Apr 2022]

Apc Products(17)

mRNA	Protein	Name
NM_001402740.1	NP_001389669.1	adenomatous polyposis coli protein isoform 10
NM_001402738.1	NP_001389667.1	adenomatous polyposis coli protein isoform 8
NM_001402729.1	NP_001389658.1	adenomatous polyposis coli protein isoform 2
NM_001402736.1	NP_001389665.1	adenomatous polyposis coli protein isoform 7
NM_001402732.1	NP_001389661.1	adenomatous polyposis coli protein isoform 4
NM_001360979.1	NP_001347908.1	adenomatous polyposis coli protein isoform 2
NM_001402727.1	NP_001389656.1	adenomatous polyposis coli protein isoform 1
NM_001402737.1	NP_001389666.1	adenomatous polyposis coli protein isoform 7
NM_001402731.1	NP_001389660.1	adenomatous polyposis coli protein isoform 3
NM_001402735.1	NP_001389664.1	adenomatous polyposis coli protein isoform 6
NM_001360980.1	NP_001347909.1	adenomatous polyposis coli protein isoform 1
NM_007462.4	NP_031488.2	adenomatous polyposis coli protein isoform 3
NM_001402728.1	NP_001389657.1	adenomatous polyposis coli protein isoform 2
NM_001402734.1	NP_001389663.1	adenomatous polyposis coli protein isoform 6
NM_001402733.1	NP_001389662.1	adenomatous polyposis coli protein isoform 5
NM_001402739.1	NP_001389668.1	adenomatous polyposis coli protein isoform 9
NM_001402730.1	NP_001389659.1	adenomatous polyposis coli protein isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta-catenin binding	IDA IDA: Inferred from direct assay	10346819	MGI
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	12874278	MGI
enables dynein complex binding	IPI IPI: Inferred from physical interaction	28057765	MGI
enables microtubule plus-end binding	IDA IDA: Inferred from direct assay	18716223	MGI
enables protease binding	IPI IPI: Inferred from physical interaction	18281465	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15327768	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	28057765	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of MAPK cascade	IGI IGI: Inferred from genetic interaction	16478791	MGI
acts upstream of MAPK cascade	IMP IMP: Inferred from mutant phenotype	16478791	MGI
acts upstream of or within T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	16025118	MGI
acts upstream of or within Wnt signaling pathway	IDA IDA: Inferred from direct assay	10346819	MGI
acts upstream of Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	18644872	MGI
acts upstream of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	11756652	MGI
acts upstream of or within Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	12645927	MGI
acts upstream of acinar cell proliferation	IGI IGI: Inferred from genetic interaction	17596282	MGI
acts upstream of acinar cell proliferation	IMP IMP: Inferred from mutant phenotype	17596282	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	12645927	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	11756652	MGI
acts upstream of or within axis specification	IMP IMP: Inferred from mutant phenotype	12645927	MGI
acts upstream of or within axonogenesis	IGI IGI: Inferred from genetic interaction	18716223	MGI
acts upstream of or within axonogenesis	IMP IMP: Inferred from mutant phenotype	15207235	MGI
acts upstream of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	11756652	MGI
acts upstream of or within canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	16887818	MGI
acts upstream of or within canonical Wnt signaling pathway involved in negative regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	17377531	MGI
acts upstream of or within canonical Wnt signaling pathway involved in positive regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	17377531	MGI
acts upstream of cell adhesion	IMP IMP: Inferred from mutant phenotype	16368433	MGI
acts upstream of cell division	IMP IMP: Inferred from mutant phenotype	16950562	MGI
acts upstream of or within cell migration	IMP IMP: Inferred from mutant phenotype	15198980	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	8945508	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	7954428	MGI
acts upstream of or within chromosome organization	IGI IGI: Inferred from genetic interaction	17200209	MGI
acts upstream of or within chromosome organization	IMP IMP: Inferred from mutant phenotype	17200209	MGI
acts upstream of or within cytoplasmic microtubule organization	IGI IGI: Inferred from genetic interaction	18716223	MGI
acts upstream of or within dorsal/ventral pattern formation	IMP IMP: Inferred from mutant phenotype	12645927	MGI
acts upstream of endothelial cell proliferation	IGI IGI: Inferred from genetic interaction	9159163	MGI
acts upstream of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	9060821	MGI
acts upstream of epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	16950562	MGI
acts upstream of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	14758356	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	10535960	MGI
acts upstream of epithelial cell proliferation involved in prostate gland development	IMP IMP: Inferred from mutant phenotype	17363566	MGI
acts upstream of fibroblast apoptotic process	IMP IMP: Inferred from mutant phenotype	17227893	MGI
acts upstream of fibroblast migration	IMP IMP: Inferred from mutant phenotype	17192415	MGI
acts upstream of or within hair follicle development	IMP IMP: Inferred from mutant phenotype	17002498	MGI
involved in insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	28057765	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	15550389	MGI
acts upstream of or within metaphase/anaphase transition of mitotic cell cycle	IGI IGI: Inferred from genetic interaction	15767571	MGI
acts upstream of or within metaphase/anaphase transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	15767571	MGI
acts upstream of microtubule depolymerization	IMP IMP: Inferred from mutant phenotype	16525027	MGI
acts upstream of microtubule polymerization	IMP IMP: Inferred from mutant phenotype	16525027	MGI
acts upstream of or within mitotic cytokinesis	IMP IMP: Inferred from mutant phenotype	17570218	MGI
acts upstream of or within muscle cell cellular homeostasis	IGI IGI: Inferred from genetic interaction	18056981	MGI
acts upstream of or within negative regulation of MAPK cascade	IGI IGI: Inferred from genetic interaction	16478791	MGI
acts upstream of or within negative regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	16478791	MGI
acts upstream of or within negative regulation of Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	18644872	MGI
acts upstream of or within negative regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	11756652	MGI
acts upstream of or within negative regulation of acinar cell proliferation	IGI IGI: Inferred from genetic interaction	17596282	MGI
acts upstream of or within negative regulation of acinar cell proliferation	IMP IMP: Inferred from mutant phenotype	17596282	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	11756652	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	11756652	MGI
acts upstream of or within negative regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	8945508	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	7954428	MGI
acts upstream of or within negative regulation of endothelial cell proliferation	IGI IGI: Inferred from genetic interaction	9159163	MGI
acts upstream of or within negative regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	9060821	MGI
acts upstream of or within negative regulation of epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	16950562	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	9037065	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	10535960	MGI
acts upstream of or within negative regulation of epithelial cell proliferation involved in prostate gland development	IMP IMP: Inferred from mutant phenotype	17363566	MGI
acts upstream of or within negative regulation of microtubule depolymerization	IMP IMP: Inferred from mutant phenotype	16525027	MGI
acts upstream of or within negative regulation of odontogenesis	IMP IMP: Inferred from mutant phenotype	17002498	MGI
acts upstream of or within nitrogen cycle metabolic process	IMP IMP: Inferred from mutant phenotype	16740478	MGI
acts upstream of odontogenesis	IMP IMP: Inferred from mutant phenotype	17002498	MGI
acts upstream of or within pattern specification process	IMP IMP: Inferred from mutant phenotype	16740478	MGI
acts upstream of or within positive regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	16368433	MGI
acts upstream of or within positive regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	15198980	MGI
acts upstream of or within positive regulation of cell division	IMP IMP: Inferred from mutant phenotype	16950562	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	26948948	MGI
acts upstream of or within positive regulation of fibroblast apoptotic process	IMP IMP: Inferred from mutant phenotype	17227893	MGI
acts upstream of or within positive regulation of fibroblast migration	IMP IMP: Inferred from mutant phenotype	17192415	MGI
acts upstream of or within positive regulation of microtubule polymerization	IMP IMP: Inferred from mutant phenotype	16525027	MGI
acts upstream of or within positive regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	16478791	MGI
involved in positive regulation of protein localization to centrosome	IMP IMP: Inferred from mutant phenotype	28057765	MGI
acts upstream of protein catabolic process	IMP IMP: Inferred from mutant phenotype	16478791	MGI
acts upstream of or within proximal/distal pattern formation	IMP IMP: Inferred from mutant phenotype	16887818	MGI
acts upstream of or within regulation of attachment of spindle microtubules to kinetochore	IMP IMP: Inferred from mutant phenotype	17227893	MGI
acts upstream of or within regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	8988060	MGI
acts upstream of or within regulation of cell differentiation	IGI IGI: Inferred from genetic interaction	17377531	MGI
acts upstream of or within regulation of cell migration	IGI IGI: Inferred from genetic interaction	17377531	MGI
acts upstream of or within regulation of epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	9771477	MGI
acts upstream of or within regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	9371501	MGI
acts upstream of or within regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	15802266	MGI
acts upstream of or within regulation of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	15802266	MGI
acts upstream of or within retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	10982921	MGI
acts upstream of or within skin development	IMP IMP: Inferred from mutant phenotype	9453487	MGI
acts upstream of or within somatic stem cell population maintenance	IGI IGI: Inferred from genetic interaction	1541640	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	1541640	MGI
acts upstream of or within stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	18725524	MGI
acts upstream of or within thymus development	IMP IMP: Inferred from mutant phenotype	16025118	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of Scrib-APC-beta-catenin complex	IDA IDA: Inferred from direct assay	16611247	MGI
located in axon	IDA IDA: Inferred from direct assay	15207235	MGI
located in axonal growth cone	IDA IDA: Inferred from direct assay	18716223	MGI
located in cell projection	IDA IDA: Inferred from direct assay	16525027	MGI
located in cell projection membrane	IDA IDA: Inferred from direct assay	16621792	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	8670282	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	31746486	MGI
located in growth cone	IDA IDA: Inferred from direct assay	15207235	MGI
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	16525027	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10346819	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	31746486	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Apc Protein Structure

APC_N_CC

Suppressor_APC

ARM

APC_rep

ARM

Arm

ARM

Arm_APC_u3

APC_u5

APC_r

APC_u9

APC_r

APC_u13

SAMP

APC_u14

APC_u15

SAMP

APC_basic

EB1_binding

0
500
1000
1500
2000
2500
2842 a.a.

Protein Preferred Names

Protein Names

adenomatous polyposis coli protein

adenomatosis polyposis coli

multiple intestinal neoplasia

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124955	proTAME	Inhibitor	99.94%	Unkown
HY-110287	Apcin	Inhibitor	99.71%	Unkown
HY-116572A	TASIN-1	Inhibitor	99.91%	Unkown
HY-130841	Apcin-A	Inhibitor	≥98.0%	Unkown
HY-13255	TAME	Inhibitor	99.51%	Unkown
HY-164561	TASIN-30	Inhibitor	98.67%	Unkown
HY-13255A	TAME hydrochloride	Inhibitor	98.31%	Unkown
HY-116572	TASIN-1 hydrochloride	Inhibitor	/	Unkown
HY-W614725	Apcin-A monohydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Apc	NCBI	NCBI:324
Macaca fascicularis	Apc	NCBI	NCBI:102126553
Susscrofa domestica	Apc	NCBI
Rattus norvegicus	Apc	NCBI	NCBI:24205

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