1. Gene
  2. APC - APC regulator of WNT signaling pathway Gene

APC - APC regulator of WNT signaling pathway Gene

Homo sapiens

Also known as GS; DP2; DP3; BTPS2; DESMD; DP2.5; PPP1R46

Gene ID: 324 | Gene type: protein coding

About APC

Cytogenetic location: 5q22.2 Genomic coordinates (GRCh38): 5:112,707,498-112,846,239 (from NCBI)

This gene has 10 transcripts (splice variants), 169 orthologues, 1 paralogue and is associated with 216 phenotypes. Ubiquitous expression in brain (RPKM 25.7), colon (RPKM 4.5) and 23 other tissues.

Summary

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and Apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers, where disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jun 2022]

APC Products(37)

mRNA Protein Name
NM_001354903.2 NP_001341832.1 adenomatous polyposis coli protein isoform j
NM_001354902.2 NP_001341831.1 adenomatous polyposis coli protein isoform i
NM_001407460.1 NP_001394389.1 adenomatous polyposis coli protein isoform j
NM_001407453.1 NP_001394382.1 adenomatous polyposis coli protein isoform h
NM_001354900.2 NP_001341829.1 adenomatous polyposis coli protein isoform g
NM_000038.6 NP_000029.2 adenomatous polyposis coli protein isoform b
NM_001354905.2 NP_001341834.1 adenomatous polyposis coli protein isoform l
NM_001407456.1 NP_001394385.1 adenomatous polyposis coli protein isoform q
NM_001407472.1 NP_001394401.1 adenomatous polyposis coli protein isoform s
NM_001407459.1 NP_001394388.1 adenomatous polyposis coli protein isoform j
NM_001407470.1 NP_001394399.1 adenomatous polyposis coli protein isoform m
NM_001354899.2 NP_001341828.1 adenomatous polyposis coli protein isoform f
NM_001127511.3 NP_001120983.2 adenomatous polyposis coli protein isoform a
NM_001407458.1 NP_001394387.1 adenomatous polyposis coli protein isoform j
NM_001354897.2 NP_001341826.1 adenomatous polyposis coli protein isoform d
NM_001354895.2 NP_001341824.1 adenomatous polyposis coli protein isoform b
NM_001407471.1 NP_001394400.1 adenomatous polyposis coli protein isoform s
NM_001407451.1 NP_001394380.1 adenomatous polyposis coli protein isoform o
NM_001407455.1 NP_001394384.1 adenomatous polyposis coli protein isoform q
NM_001407454.1 NP_001394383.1 adenomatous polyposis coli protein isoform q
NM_001354906.2 NP_001341835.1 adenomatous polyposis coli protein isoform m
NM_001407447.1 NP_001394376.1 adenomatous polyposis coli protein isoform c
NM_001354898.2 NP_001341827.1 adenomatous polyposis coli protein isoform e
NM_001354896.2 NP_001341825.1 adenomatous polyposis coli protein isoform c
NM_001354901.2 NP_001341830.1 adenomatous polyposis coli protein isoform h
NM_001354904.2 NP_001341833.1 adenomatous polyposis coli protein isoform k
NM_001407450.1 NP_001394379.1 adenomatous polyposis coli protein isoform b
NM_001407448.1 NP_001394377.1 adenomatous polyposis coli protein isoform c
NR_176365.1
NR_176366.1
NM_001407469.1 NP_001394398.1 adenomatous polyposis coli protein isoform r
NM_001127510.3 NP_001120982.1 adenomatous polyposis coli protein isoform b
NM_001407457.1 NP_001394386.1 adenomatous polyposis coli protein isoform q
NM_001407467.1 NP_001394396.1 adenomatous polyposis coli protein isoform r
NM_001407449.1 NP_001394378.1 adenomatous polyposis coli protein isoform c
NM_001407446.1 NP_001394375.1 adenomatous polyposis coli protein isoform n
NM_001407452.1 NP_001394381.1 adenomatous polyposis coli protein isoform p

APC Protein Structure

Suppressor_APC

Suppressor_APC: Adenomatous polyposis coli tumour suppressor protein (128 - 208)

Arm

Arm: Armadillo/beta-catenin-like repeat (522 - 552)

Arm

Arm: Armadillo/beta-catenin-like repeat (649 - 689)

Arm

Arm: Armadillo/beta-catenin-like repeat (691 - 730)

APC_15aa

APC_15aa: APC 15 residue motif (1020 - 1035)

APC_15aa

APC_15aa: APC 15 residue motif (1136 - 1151)

APC_15aa

APC_15aa: APC 15 residue motif (1155 - 1170)

APC_15aa

APC_15aa: APC 15 residue motif (1172 - 1186)

APC_r

APC_r: APC repeat (1256 - 1281)

APC_r

APC_r: APC repeat (1370 - 1394)

APC_r

APC_r: APC repeat (1486 - 1510)

SAMP

SAMP: SAMP Motif (1569 - 1589)

APC_r

APC_r: APC repeat (1637 - 1661)

SAMP

SAMP: SAMP Motif (1719 - 1738)

APC_r

APC_r: APC repeat (1841 - 1866)

APC_r

APC_r: APC repeat (1948 - 1973)

APC_r

APC_r: APC repeat (2008 - 2031)

SAMP

SAMP: SAMP Motif (2034 - 2051)

APC_basic

APC_basic: APC basic domain (2223 - 2579)

EB1_binding

EB1_binding: EB-1 Binding Domain (2670 - 2843)

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  • 2843 a.a.
Protein Preferred Names Protein Names

adenomatous polyposis coli protein

APC, WNT signaling pathway regulator

WNT signaling pathway regulator

adenomatosis polyposis coli tumor suppressor

adenomatous polyposis coli (APC)

deleted in polyposis 2.5

epididymis secretory sperm binding protein

protein phosphatase 1, regulatory subunit 46

Related Diseases

Diseases Alias
Tumor Predisposition Syndrome

TPDS

Tumor Predisposition

Thoracic Cancer

Thoracic Tumor

Thorax Cancer

Thorax Neoplasm

Tumor Of Thorax

Thoracic Neoplasms

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Melanoma, Uveal

Uveal Melanoma

Choroidal Melanoma

Melanoma Of Uvea

Iris Melanoma

Malignant Melanoma Of Choroid

Malignant Melanoma Of Iris

Duodenal Benign Neoplasm

Neoplasm Of Duodenum

Neoplasm Of The Duodenum

Cancer Of Duodenum

Fibromatosis
Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Juvenile Polyposis Syndrome

JPS

Juvenile Intestinal Polyposis

Jip

Pji

Juvenile Gastrointestinal Polyposis

Juvenile Polyposis

Polyposis, Juvenile Intestinal

Polyposis, Familial, Of Entire Gastrointestinal Tract

Polyposis Familial Of Entire Gastrointestinal Tract

Polyposis Juvenile Intestinal

Polyposis Syndrome, Juvenile

Pseudohypoparathyroidism

Familial Pseudohypoparathyroidism

Parathyroid Hormone Resistant Hypoparathyroidism

Php - [Pseudohypoparathyroidism]

Constitutional Chronic Hypocalcaemia

Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Desmoplastic/Nodular Medulloblastoma

Medulloblastoma With Extensive Nodularity

Desmoplastic Medulloblastoma

Medulloblastoma, Somatic

Medulloblastoma, Desmoplastic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Mben

Medulloblastoma Desmoplastic

Neuroectodermal Tumors, Primitive

Medulloblastomas

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site

Contractures, Pterygia, And Spondylocarpotarsal Fusion Syndrome 1a

Multiple Pterygium Syndrome, Autosomal Dominant

CPSFS1A

Contractures, Pterygia, And Spondylocarpostarsal Fusion Syndrome 1a

Autosomal Dominant Disease

Contractures, Pterygia, And Variable Skeletal Fusions Syndrome 1a

Cpskf1a

Pterygium Syndrome, Multiple

Autosomal Dominant

Arthrogryposis, Distal, Type 8, Formerly

Da8, Formerly

Autosomal Dominant Multiple Pterygium Syndrome

Distal Arthrogryposis Type 8

Arthrogryposis, Distal, Type 8

Da8

Pterygium Syndrome, Multiple, Autosomal Dominant

Autosomal Dominant Disorder

Urinary System Disease

Abnormality Of The Urinary System

Non-Neoplastic Urinary Tract Disease

Urinary Tract Disease

Urinary Tract Diseases

Urinary Tract Anomaly

Urologic Diseases

Non-Neoplastic Urinary System Disorder

Congenital Malformation Of The Urinary System

Lymphangioma

Lymphatic Malformation

Lymphatic Malformations

Benign Lymphangioma

Congenital Lymphangioma

Lymphangiomas

Ampulla Of Vater Benign Neoplasm

Tumor Of The Ampulla Of Vater

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Cardiovascular Organ Benign Neoplasm
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Cancer Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Large Intestine Cancer
Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site

Immune System Disease

Abnormality Of The Immune System

Immune System And Disorders

Immune System Diseases

Gastric Adenocarcinoma

Adenocarcinoma Of Stomach

Stomach Adenocarcinoma

Adenocarcinoma Gastric

Intestinal Type Adenocarcinoma Of Unspecified Site

Diffuse Type Adenocarcinoma Of Unspecified Site

Mismatch Repair Cancer Syndrome 1

Turcot Syndrome

Constitutional Mismatch Repair Deficiency Syndrome

Mismatch Repair Deficiency

Mmr Deficiency

MMRCS1

Cmmrds

Childhood Cancer Syndrome

Brain Tumor-Polyposis Syndrome 1

Btps1

Btp1 Syndrome

Mismatch Repair Cancer Syndrome

Childhood Cancer

Brain Tumor-Polyposis Syndrome

Cns Tumors With Familial Polyposis Of The Colon

Glioma-Polyposis Syndrome

Mmrcs

Malignant Tumors Of The Central Nervous System Associated With Familial Polyposis Of The Colon

Biallelic Mismatch Repair Deficiency Syndrome

Bmmrd

Cmmr-D Syndrome

Infratentorial Cancer

Infratentorial Neoplasms

Brain Neoplasm, Infratentorial

Malignant Infratentorial Tumors

Brain Cancer

Malignant Neoplasm Of Brain

Adult Brain Tumor

Brain Neoplasms

Brain Neoplasm

Neoplasm Of Brain

Primary Malignant Neoplasm Of Brain

Brain Tumors

Adult Malignant Brain Neoplasm

Brain Neoplasm, Adult

Bt - Brain Tumour

Malignant Brain Tumour

Malignant Primary Brain Neoplasm

Malignant Primary Brain Tumor

Malignant Tumor Of Adult Brain

Malignant Tumor Of Brain

Primary Brain Neoplasm

Primary Brain Tumor

Tumor Of The Brain

Brain Tumor, Adult

Brain Tumor Primary

Malignant Primary Brain Tumors

Primary Brain Tumors

Cancer, Brain

Brain Tumor, Primary

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Male Reproductive System Disease

Genital Diseases, Male

Disorder Of Male Reproductive System

Autosomal Genetic Disease

Autosomal Hereditary Disorder

Anus Disease

Anal Fissure

Ulcer Of Anus

Anus Diseases

Anal Disease

Anal Fissure And Fistula

Anal Ulcer

Fissure In Ano

Nontraumatic Tear Of Anus

Solitary Anal Ulcer

Abnormality Of The Anus

Anal Disorders

Ulcer Of Anus And Rectum

Solitary Ulcer Of Anus

Stercoral Ulcer Of Anus

Endocrine Gland Cancer

Endocrine Neoplasm

Malignant Neoplasm Of Endocrine Gland

Endocrine Gland Neoplasms

Endocrine Tumor

Malignant Endocrine Tumor

Malignant Tumour Of Endocrine Gland

Neoplasm Of Endocrine Gland

Neoplasm Of Endocrine System

Neoplasm Of The Endocrine System

Carcinoma Of Endocrine Gland

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma

Lymphoma, Non-Hodgkin

NHL

Lymphoma, Non-Hodgkin, Somatic

Lymphoma, Follicular, Somatic

Familial Non-Hodgkin Lymphoma

Lymphoma Non-Hodgkins

Follicular Lymphoma, Somatic

Lymphosarcoma

Non-Hodgkins Lymphoma

Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer

Desmoid Disease, Hereditary

Fif

DESMD

Hereditary Desmoid Disease

Familial Infiltrative Fibromatosis

Fibromatosis, Familial Infiltrative

Fibromatosis, Aggressive

Eye Disease

Eye Diseases

Abnormality Of The Eye

Toxoplasma Oculopathy

Cell Type Benign Neoplasm
Desmoid Tumor

Aggressive Fibromatosis

Desmoid Type Fibromatosis

Familial Infiltrative Fibromatosis

Desmoid Disorder, Hereditary

Fif

Fibromatosis, Familial Infiltrative

Deep Fibromatosis

Desmoid Fibromatosis

Hereditary Desmoid Disease

Musculoaponeurotic Fibromatosis

Desmoid-Type Fibromatosis

Fibromatosis, Aggressive

Desmoid Disease, Hereditary

Musculo-Aponeurotic Fibromatosis

Gastrointestinal System Benign Neoplasm
Retinal Disease

Retinal Diseases

Retinal Disorder

Retinal Disorders

Lymphatic System Disease

Lymphatic Diseases

Adenopathy

Disease Of Lympoid System

Disorder Of Lymph Node And Lymphatics

Disorder Of Lymphatic System

Disorder Of Lymphoid System

Lymphangiopathy

Lymphatic Disease

Lymphatic Disorder

Lympoid System Disease

Abnormality Of The Lymphatic System

Peutz-Jeghers Syndrome

PJS

Polyposis, Hamartomatous Intestinal

Polyps-And-Spots Syndrome

Lentiginosis, Perioral

Periorificial Lentiginosis Syndrome

Hamartomatous Polyp

Colonic Hamartomatous Polyp

Gastric Peutz-Jeghers Polyp

Peutz Jeghers Colon Polyp

Peutz Jeghers Polyp

Peutz-Jeghers Polyp Of Small Intestine

Peutz-Jeghers Small Bowel Hamartoma

Peutz Jeghers Polyposis

Intestinal Polyposis-Cutaneous Pigmentation Syndrome

Peutz-Jeghers Polyposis

Polyposis, Intestinal, Ii

Hamartomatous Intestinal Polyposis

Intestinal Hamartomatous Polyposis

Peutz-Jeghers Polyp

Peutz-Jeghers Polyp Of The Stomach

Peutz Jehgers Polyp

Peutz-Jeghers Polyps Of Small Bowel

Villous Adenoma

Adenoma Villous

Adenoma, Villous

Adenoma

Acinar Cell Adenoma

Adenomas

Acinic Cell Adenoma

Periampullary Adenoma
Gallbladder Cancer

Gallbladder Carcinoma

Gallbladder Neoplasm

Malignant Neoplasm Of Gallbladder

Malignant Tumour Of Gallbladder

Gallbladder Ca

Localized Malignant Gallbladder Neoplasm

Malignant Tumor Of The Gallbladder

Tumor Of The Gallbladder

Cancer Of The Gallbladder

Carcinoma Gallbladder

Carcinoma Of Gallbladder

Gallbladder Neoplasms

Malignant Neoplasm Of Gallbladder Localized

Cancer Of Gallbladder

Primary Malignant Neoplasm Of Gallbladder

Malignant Ovarian Surface Epithelial-Stromal Neoplasm

Malignant Ovarian Surface Epithelial-Stromal Tumor

Duodenum Adenoma
Colonic Disease

Colonic Diseases

Colon Disorder

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Mccune-Albright Syndrome

Mass Syndrome

Polyostotic Fibrous Dysplasia

MAS

Fibrous Dysplasia Of Bone

Albright Syndrome

Mass Phenotype

Overlap Connective Tissue Disease

Mccune Albright Syndrome

Osteitis Fibrosa Disseminata

OCTD

Albright'S Disease

Pfd

Pofd

Albright'S Syndrome

Mccune-Albright Syndrome, Somatic, Mosaic

Albright'S Disease Of Bone

Albright'S Syndrome With Precocious Puberty

Albright-Mccune-Sternberg Syndrome

Albright-Sternberg Syndrome

Fibrous Dysplasia With Pigmentary Skin Changes And Precocious Puberty

Gonadotropin-Independent Female-Limited Sexual Precocity

Fibrous Dysplasia Polyostotic

Fibrous Dysplasia, Polyostotic

Connective Tissue Disease

Connective Tissue Diseases

Connective Tissue Disorder

Abnormality Of Connective Tissue

Disorder Of Connective Tissue

Connective Tissue Disorders

Germinoma
Rectum Cancer

Malignant Neoplasm Of Rectum

Rectal Cancer

Cancer Of Rectum

Carcinoma Of Rectum

Carcinoma Of The Rectum

Malignant Rectal Tumor

Malignant Rectum Tumor

Malignant Tumor Of Rectum

Rectal Carcinoma

Rectal Cancers

Cancer, Rectal

Fibrous Dysplasia

Fibrous Dysplasia Of Bone

Gastric Adenocarcinoma And Proximal Polyposis Of The Stomach

Polyposis, Gastric

GAPPS

Polyposis Of Gastric Fundus Without Polyposis Coli

Fundic Gland Polyposis

Familial Fundic Gland Polyposis With Gastric Cancer

Gastric Polyposis

Epidermoid Cysts

Epidermoid Cyst

Sebaceous Cyst

Epidermal Inclusion Cyst

Epidermal Cyst

Colonic Benign Neoplasm

Colon Neoplasm

Colonic Mass

Colonic Tumor

Neoplasm Of Colon

Neoplasm Of The Colon

Colonic Neoplasms

Colon Cancer

Colon Carcinoma Nos

Colonic Cancer

Metastatic Colon Cancer Nos

Large Intestine Adenoma

Adenoma Of Large Intestine

Familial Adenomatous Polyposis

Adenomatous Polyposis Coli

Fap

Familial Multiple Polyposis Syndrome

Adenomatous Polyposis Of The Colon

Familial Intestinal Polyposis

Familial Polyposis Coli

Fpc

Familial Adenomatous Polyposis Of The Colon

Familial Multiple Polyposis

Familial Polyposis Of The Colon

Hereditary Polyposis Coli

Polyposis, Adenomatous Intestinal

Adenomatous Familial Polyposis

Adenomatous Familial Polyposis Syndrome

Myh-Associated Polyposis

Colorectal Adenomatous Polyposis

Adenomatous Polyposis, Familial

Mutyh-Associate Polyposis

Pancreatic Cancer

Pancreatic Carcinoma

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Carcinoma Of Pancreas

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Cancer Of The Pancreas

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Colon Adenoma

Adenomatous Polyp Of Colon

Malignant Astrocytoma

Astrocytic Tumor

Astrocytoma Of Brain

Astrocytoma Of Cerebrum

Astroglioma

Cerebral Astrocytoma

Astrocytoma

Craniopharyngioma

Neoplasm Of Rathke'S Pouch

Adamantinomatous Tumor

Craniopharyngeal Duct Tumor

Dysodontogenic Epithelial Tumor

Rathke'S Pouch Tumor

Oropharynx Cancer

Oropharyngeal Cancer

Oropharyngeal Carcinoma

Malignant Neoplasm Of Oropharynx

Malignant Oropharyngeal Tumor

Malignant Tumor Of Oropharynx

Malignant Tumour Of Mesopharynx

Oropharyngeal Cancer, Adult

Cancer Of The Oropharynx

Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma

Barrett Esophagus

Barrett Esophagus/Esophageal Adenocarcinoma

Barrett'S Esophagus

Barrett Metaplasia

Barrett'S Ulcer Of Esophagus

Ulcerative Esophagitis

Barrett'S Esophagus With Esophagitis

Barrett'S Oesophagus

Barretts Syndrome

Barrett Syndrome

BE

Peptic Ulcer Of Esophagus

Adenocarcinoma Of Esophagus

Hemorrhoid

Hemorrhoids

Hemorrhoidal Disease

Rectal Diseases

Piles

Unspecified Haemorrhoids Without Complication

Skin Disease

Skin Diseases

Abnormality Of The Skin

Skin Diseases, Genetic

Genodermatosis

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

Reproductive System Disease

Abnormality Of The Genital System

Genital System Disease

Reproductive System Disorder

Parathyroid Carcinoma

Parathyroid Cancer

Parathyroid Neoplasms

Malignant Tumor Of Parathyroid Gland

PRTC

Carcinoma Of Parathyroid Gland

Malignant Neoplasm Of Parathyroid Gland

Parathyroid Gland Adenocarcinoma

Parathyroid Gland Cancer

Parathyroid Neoplasm

Parathyroid Gland Carcinoma

Malignant Neoplasm Of The Parathyroid

Neoplasm Of Parathyroid Gland

Parathyroid Gland Neoplasm

Cancer Of The Parathyroid

Cancer Of The Parathyroid Gland

Malignant Neoplasm Of Parathyroid

Malignant Parathyroid Gland Neoplasm

Malignant Parathyroid Gland Tumor

Malignant Parathyroid Neoplasm

Malignant Parathyroid Tumor

Malignant Tumor Of Parathyroid

Parathyroid Adenocarcinoma

Neoplasm Of The Parathyroid Gland

Carcinoma, Parathyroid

Adenocarcinoma

Adenocarcinomas

Adenoacanthoma Of Unspecified Site

Adenocarcinoid Of Unspecified Site

Adenocarcinoid Tumour Of Unspecified Site

Adenocarcinoma And Carcinoid Combined Of Unspecified Site

Adenocarcinoma Nos

Female Reproductive System Disease

Genital Diseases, Female

Female Reproductive System Disorder

Chromosome 2q35 Duplication Syndrome

Syndactyly

Syndactyly Type 1

Sdty1

Syndactyly, Type I

Sd1

Zygodactyly

Syndactyly, Type 1, With Or Without Craniosynostosis

Non-Syndromic Syndactyly

Symphalangism

Symphalangy

Webbing Of Digits

Syndactyly, Type 1

Cornelia De Lange Syndrome

De Lange Syndrome

Brachmann De Lange Syndrome

Brachmann-De Lange Syndrome

Cdls

Bdls

Typus Degenerativus Amstelodamensis

Gastrointestinal Adenoma

Gi Adenoma

Digestive System Adenoma

Lymphatic System Cancer
Sensory System Disease
Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell

Hematologic Cancer

Hematologic Neoplasm

Hematologic Malignancies

Hematologic Neoplasms

Blood Cancer

Hematologic Malignancy

Hematological Tumors

Hematopoietic And Lymphoid System Tumor

Hematopoietic Cancer

Hematopoietic Neoplasm

Hematopoietic Tumors

Malignant Hematopoietic Neoplasm

Liquid Tumor

Hematopoietic Neoplasms

Polyposis Syndrome, Hereditary Mixed, 1

HMPS1

Colorectal Adenoma And Carcinoma 1

Crac1

Colorectal Cancer 4

Chromosome 15q13-Q14 Duplication Syndrome, 40-Kb

Colorectal Cancer, Susceptibility To, 4

Hereditary Mixed Polyposis Syndrome 1

Polyposis Syndrome, Hereditary Mixed 1

CRCS4

Susceptibility To Colorectal Cancer On Chromosome 15

Polyposis Syndrome, Mixed Hereditary 1

Adenomatous Polyps

Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus

Apc-Associated Polyposis Conditions
Colon Adenocarcinoma

Adenocarcinoma Of Colon

Adenocarcinoma Of The Colon

Colonic Adenocarcinoma

Malignant Exocrine Pancreas Neoplasm

Malignant Neoplasm Of The Exocrine Pancreas

Malignant Tumor Of Exocrine Pancreas

Malignant Tumour Of Exocrine Pancreas

Familial Adenomatous Polyposis 1

Gardner Syndrome

Brain Tumor-Polyposis Syndrome 2

Familial Polyposis Of The Colon

Adenomatous Polyposis Coli

FAP1

Adenomatous Polyposis Of The Colon

Apc

Fpc

Gardner'S Syndrome

Polyposis, Adenomatous Intestinal

Adenoma, Periampullary, Somatic

Intestinal Polyposis, Osteomas, Sebaceous Cysts

Polyposis Coli And Multiple Hard And Soft Tissue Tumors

Apc-Related Attenuated Familial Adenomatous Polyposis

Apc-Related Afap

Apc-Related Attenuated Fap

Apc-Related Attenuated Familial Polyposis Coli

Turcot Syndrome With Polyposis

Gardners Syndrome

Adenomatous Polyposis Coli, Susceptibility To

Adenomatous Polyposis, Familial, Type 1

Hepatocellular Adenoma

Adenoma Hepatocellular

Rectum Adenocarcinoma

Rectal Adenocarcinoma

Adenocarcinoma Of Rectum

Lung Cancer Susceptibility 3

Lung Adenocarcinoma

Adenocarcinoma Of Lung

LNCR3

Adenocarcinoma Of Lung, Susceptibility To

Bronchogenic Lung Adenocarcinoma

Nonsmall Cell Adenocarcinoma

Adenocarcinoma Lung

Lung Adenocarcinomas

Non-Small Cell Adenocarcinoma

Intestinal Benign Neoplasm

Intestinal Neoplasms

Intestinal Tumors

Intestine Growth

Neoplasm Of Intestinal Tract

Bile Duct Disease

Bile Duct Diseases

Bile Duct Disorder

Disorder Of Bile Duct

Integumentary System Disease
Gastrointestinal System Disease

Gastrointestinal Disease

Gastrointestinal Diseases

Alimentary System Disease

Digestive System Disorder

Gastroenteropathy

Gastrointestinal Disorder

Git Disease

Digestive System Diseases

Gastrointestinal Disorders

Digestive System Disease

Digestive System Disorders

Colorectal Adenoma

Colorectal Adenomas

Adenoma Of Large Intestine

Hepatoblastoma
Familial Adenomatous Polyposis Due To 5q22.2 Microdeletion

Colorectal Adenomatous Polyposis Due To Monosomy 5q22.2

Fap Due To Monosomy 5q22.2

Familial Adenomatous Polyposis Due To Del(5)(Q22.2)

Familial Adenomatous Polyposis Due To Monosomy 5q22.2

Familial Polyposis Coli Due To Monosomy 5q22.2

Gastrointestinal System Cancer

Digestive System Neoplasms

Gastrointestinal Neoplasms

Digestive System Cancer

Gastrointestinal Tract Cancer

Gi Tumor

Digestive System Neoplasm

Digestive System Carcinoma

Malignant Neoplasm Of Gastrointestinal Tract

Cancer Of Digestive System

Colorectal Cancer, Hereditary Nonpolyposis, Type 5

HNPCC5

Hereditary Nonpolyposis Colorectal Cancer Type 5

Hereditary Non-Polyposis Colorectal Cancer 5

Cancer, Colorectal, Nonpolyposis, Hereditary, Type 5

Ocular Cancer

Eye Carcinoma

Eye Neoplasm

Eye Cancer

Eye Neoplasms

Malignant Eye Neoplasm

Neoplasm Of Eye

Neoplasm Of Eye Proper

Ocular Tumor

Carcinoma Of Eye

Ocular Carcinoma

Malignant Tumor Of Eye

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Inherited Cancer-Predisposing Syndrome

Hereditary Cancer-Predisposing Syndrome

Lynch Syndrome

Hereditary Nonpolyposis Colon Cancer

Hereditary Nonpolyposis Colorectal Cancer

Hereditary Nonpolyposis Colorectal Carcinoma

Hereditary Nonpolyposis Colorectal Neoplasms

Familial Nonpolyposis Colon Cancer

Hnpcc

Coca 1

Hereditary Defective Mismatch Repair Syndrome

Hereditary Non-Polyposis Colon Cancer

Hereditary Non-Polyposis Colon Cancer Syndrome

Hereditary Non-Polyposis Colorectal Cancer

Hereditary Non-Polyposis Colorectal Cancer Syndrome

Hereditary Nonpolyposis Colon Cancer Syndrome

Hereditary Nonpolyposis Colorectal Cancer Syndrome

Hereditary Nonpolyposis Colorectal Neoplasm

Hnpcc - Hereditary Nonpolyposis Colon Cancer

Cancer Family Syndrome

Familial Nonpolyposis Colorectal Cancer

Colon Cancer, Familial Nonpolyposis

Colorectal Neoplasms, Hereditary Nonpolyposis

Cancer, Colorectal, Nonpolyposis, Hereditary

Colorectal Cancer, Hereditary Nonpolyposis, Type 1

Anal Gland Neoplasm

Anal Gland Neoplasms

Gastric Cancer

Stomach Cancer

Stomach Carcinoma

Gastric Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach

Cenani-Lenz Syndactyly Syndrome

Syndactyly Type 7

Cenani Syndactylism

Cenani-Lenz Syndactyly

CLSS

Syndactyly Cenani Lenz Type

Cenani-Lenz Syndrome

Syndactyly, Type Vii

Cenani-Lenz Type Syndactyly

Cenani Syndactyly

Syndactyly Type Vii

Intestinal Disease

Intestinal Diseases

Central Nervous System Cancer

Central Nervous System Tumor

Central Nervous System Tumors

Cns Neoplasm

Malignant Neoplasm Of Central Nervous System

Malignant Tumor Of Cns

Neoplasm Of Central Nervous System

Malignant Neoplasm Of The Central Nervous System

Neoplasm Of The Central Nervous System

Central Nervous System Neoplasms

Central Nervous System Neoplasm

Small Intestine Benign Neoplasm

Neoplasm Of Small Intestine

Small Intestinal Neoplasm

Neoplasm Of The Small Intestine

Small Bowel Cancer

Small Intestine Cancer

Malignant Neoplasm Of Small Intestine, Unspecified

Malignant Tumour Of Small Bowel

Malignant Tumour Of Small Intestine

Primary Malignant Neoplasm Of Meckel Diverticulum

Retinal Cancer

Malignant Neoplasm Of Retina

Retinal Neoplasms

Malignant Retinal Neoplasm

Malignant Tumor Of Retina

Neoplasm Of Retina

Retinal Tumor

Retinal Neoplasm

Cancer Of The Retina

Malignant Retinal Tumour

Malignant Tumour Of Retina

Primary Malignant Neoplasm Of Retina

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus APC RGD RGD:2123
Felis catus APC VGNC VGNC:99681
Macaca mulatta APC VGNC VGNC:84282
Canis familiaris APC VGNC VGNC:99669
Mus musculus APC MGD MGI:88039
Bos taurus APC VGNC VGNC:55103
Macaca fascicularis APC NCBI NCBI:102126553
Susscrofa domestica APC NCBI
Others APC NCBI