1. Gene
  2. Apc - APC regulator of WNT signaling pathway Gene

Apc - APC regulator of WNT signaling pathway Gene

Rattus norvegicus

Also known as RATAPC

Gene ID: 24205 | Gene type: protein coding

About Apc

Primary_assembly 18: 25,864,222-25,922,696 forward strand.mRatBN7.2:CM026991.1

This gene has 3 transcripts (splice variants), 169 orthologues, 1 paralogue and is associated with 90 phenotypes. Biased expression in Brain (RPKM 51.2), Lung (RPKM 138.6) and 9 other tissues.

Summary

Enables microtubule binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; negative regulation of cardiac muscle cell proliferation; and regulation of glutamate metabolic process. Located in several cellular components, including axonal growth cone; cell body fiber; and lateral plasma membrane. Part of protein-containing complex. Colocalizes with neuron projection and synapse. Used to study anemia; colon adenocarcinoma; colon cancer; and familial adenomatous polyposis. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial Cancer (multiple); familial adenomatous polyposis 1; hereditary desmoid disease; and medulloblastoma. Orthologous to human APC (APC regulator of Wnt signaling pathway). [provided by Alliance of Genome Resources, Apr 2022]

Apc Products(1)

mRNA Protein Name
NM_012499.1 NP_036631.1 adenomatous polyposis coli protein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables microtubule binding IDA
IDA: Inferred from direct assay
12610628 RGD
enables microtubule binding IMP
IMP: Inferred from mutant phenotype
15670646 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9786987 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
19858196 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to nerve growth factor stimulus IEP
IEP: Inferred from expression pattern
22399805 RGD
involved in establishment or maintenance of cell polarity IDA
IDA: Inferred from direct assay
12610628 RGD
involved in negative regulation of cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
28948298 RGD
involved in neuron projection development IMP
IMP: Inferred from mutant phenotype
16303851 RGD
involved in pancreas development IEP
IEP: Inferred from expression pattern
16688812 RGD
involved in regulation of glutamate metabolic process IDA
IDA: Inferred from direct assay
19858196 RGD
involved in response to alcohol IEP
IEP: Inferred from expression pattern
18945221 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
11689703 RGD
Cellular Component GO Annotation Evidence Reference Source
located in axonal growth cone IDA
IDA: Inferred from direct assay
15670646 RGD
located in cell body fiber IDA
IDA: Inferred from direct assay
23001297 RGD
located in cell cortex IDA
IDA: Inferred from direct assay
18042042 RGD
located in dendrite IDA
IDA: Inferred from direct assay
15670646 RGD
located in growth cone IDA
IDA: Inferred from direct assay
16303851 RGD
located in lamellipodium IDA
IDA: Inferred from direct assay
15670646 RGD
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
8638125 RGD
located in microtubule IDA
IDA: Inferred from direct assay
16767746 RGD
located in neuron projection terminus IDA
IDA: Inferred from direct assay
18042042 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
8638125 RGD
located in nuclear membrane IDA
IDA: Inferred from direct assay
18042042 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
19858196 RGD
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
8638125 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Apc Protein Structure

Suppressor_APC

Suppressor_APC: pfam11414 (134 - 214)

ARM

ARM: smart00185 (347 - 399)

APC_rep

APC_rep: pfam18797 (400 - 473)

ARM

ARM: sd00043 (497 - 533)

ARM

ARM: smart00185 (537 - 578)

ARM

ARM: sd00043 (541 - 578)

ARM

ARM: sd00043 (588 - 620)

ARM

ARM: sd00043 (628 - 669)

ARM

ARM: smart00185 (674 - 714)

ARM

ARM: sd00043 (678 - 712)

Arm

Arm: pfam00514 (716 - 756)

ARM

ARM: sd00043 (720 - 756)

Arm_APC_u3

Arm_APC_u3: pfam16629 (757 - 1044)

APC_u5

APC_u5: pfam16630 (1061 - 1160)

APC_r

APC_r: pfam05923 (1281 - 1298)

APC_u9

APC_u9: pfam16633 (1307 - 1392)

APC_r

APC_r: pfam05923 (1662 - 1685)

APC_u13

APC_u13: pfam16634 (1687 - 1739)

SAMP

SAMP: pfam05924 (1741 - 1762)

APC_u14

APC_u14: pfam16635 (1771 - 1864)

APC_u15

APC_u15: pfam16636 (1898 - 1972)

SAMP

SAMP: pfam05924 (2059 - 2078)

APC_basic

APC_basic: pfam05956 (2250 - 2595)

EB1_binding

EB1_binding: pfam05937 (2697 - 2869)

  • 0
  • 500
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  • 1500
  • 2000
  • 2500
  • 2870 a.a.
Protein Preferred Names Protein Names

adenomatous polyposis coli protein

APC, WNT signaling pathway regulator

WNT signaling pathway regulator

adenomatosis polyposis coli

Orthologs Information

Species Symbol Source ID
Homo sapiens Apc NCBI NCBI:324
Macaca fascicularis Apc NCBI NCBI:102126553
Mus musculus Apc NCBI NCBI:11789
Susscrofa domestica Apc NCBI