UBE2J2 - ubiquitin conjugating enzyme E2 J2 Gene

Homo sapiens

Also known as UBC6; NCUBE2; NCUBE-2; PRO2121

Gene ID: 118424 | Gene type: protein coding

About UBE2J2

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,253,912-1,273,854 (from NCBI)

This gene has 20 transcripts (splice variants), 208 orthologues and 24 paralogues. Broad expression in testis (RPKM 15.7), fat (RPKM 6.0) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. This Enzyme is located in the membrane of the endoplasmic reticulum. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

UBE2J2 Products(4)

mRNA	Protein	Name
NM_058167.3	NP_477515.2	ubiquitin-conjugating enzyme E2 J2 isoform 2
NM_194315.2	NP_919296.1	ubiquitin-conjugating enzyme E2 J2 isoform 1
NM_194457.2	NP_919439.1	ubiquitin-conjugating enzyme E2 J2 isoform 3
NM_194458.2	NP_919440.1	ubiquitin-conjugating enzyme E2 J2 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables ubiquitin conjugating enzyme activity	IDA IDA: Inferred from direct assay	20061386	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	24019521	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERAD pathway	IMP IMP: Inferred from mutant phenotype	24807418	GOA
involved in protein K6-linked ubiquitination	IDA IDA: Inferred from direct assay	36528027	GOA
involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	24807418	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of ubiquitin ligase complex	IPI IPI: Inferred from physical interaction	24807418	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2J2 Protein Structure

UQ_con

0
100
200
259 a.a.

Protein Preferred Names

Protein Names

ubiquitin-conjugating enzyme E2 J2

E2 ubiquitin-conjugating enzyme J2

UBE2J2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	UBE2J2	Q8N2K1	TRIM59	Homo sapiens	Q8IWR1	Y2H Array	32296183
Intra	UBE2J2	Q8N2K1	TRIM59	Homo sapiens	Q8IWR1	Y2H Prey Pooling	32296183
Intra	UBE2J2	Q8N2K1	ELOVL7	Homo sapiens	A1L3X0	Y2H Prey Pooling	32296183
Intra	UBE2J2	Q8N2K1	ELOVL7	Homo sapiens	A1L3X0	Y2H Array	32296183
Intra	UBE2J2	Q8N2K1	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	UBE2J2	Q8N2K1	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	UBE2J2	Q8N2K1	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	UBE2J2	Q8N2K1	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	UBE2J2	Q8N2K1	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBE2J2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71404	UBE2J2 Protein, Human (GST)	Q8N2K1-1 (E124-R224)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15351	UBE2J2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	UBE2J2	VGNC	VGNC:79189
Bos taurus	UBE2J2	VGNC	VGNC:36586
Rattus norvegicus	UBE2J2	RGD	RGD:1359523
Mus musculus	UBE2J2	MGD	MGI:2153608
Canis familiaris	UBE2J2	VGNC	VGNC:48056
Felis catus	UBE2J2	VGNC	VGNC:107687
Others	UBE2J2	NCBI

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