ELOVL7 - ELOVL fatty acid elongase 7 Gene

Homo sapiens

Gene ID: 79993 | Gene type: protein coding

About ELOVL7

Cytogenetic location: 5q12.1 Genomic coordinates (GRCh38): 5:60,751,791-60,844,269 (from NCBI)

This gene has 7 transcripts (splice variants), 230 orthologues and 6 paralogues. Broad expression in prostate (RPKM 8.7), skin (RPKM 7.9) and 18 other tissues.

Summary

Enables fatty acid elongase activity. Involved in fatty acid elongation, polyunsaturated fatty acid; fatty acid elongation, saturated fatty acid; and very long-chain fatty acid biosynthetic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

ELOVL7 Products(4)

mRNA	Protein	Name
NM_001104558.2	NP_001098028.1	elongation of very long chain fatty acids protein 7 isoform 1
NM_001297617.2	NP_001284546.1	elongation of very long chain fatty acids protein 7 isoform 2
NM_001297618.2	NP_001284547.1	elongation of very long chain fatty acids protein 7 isoform 3
NM_024930.3	NP_079206.2	elongation of very long chain fatty acids protein 7 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables fatty acid elongase activity	EXP EXP: Inferred from Experiment	19826053	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20937905	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in fatty acid elongation, polyunsaturated fatty acid	IDA IDA: Inferred from direct assay	20937905	GOA
involved in fatty acid elongation, saturated fatty acid	IDA IDA: Inferred from direct assay	19826053	GOA
involved in very long-chain fatty acid biosynthetic process	IDA IDA: Inferred from direct assay	19826053	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	20937905	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELOVL7 Protein Structure

ELO

0
100
200
281 a.a.

Protein Preferred Names

Protein Names

elongation of very long chain fatty acids protein 7

3-keto acyl-CoA synthase ELOVL7

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia 38

Spinocerebellar Ataxia Type 38	SCA38
Ataxia, Spinocerebellar, Type 38

Spinocerebellar Ataxia 34

Erythrokeratodermia With Ataxia	Spinocerebellar Ataxia Type 34
SCA34	Erythrokeratodermia - Ataxia
Giroux Barbeau Syndrome	Spinocerebellar Ataxia And Erythrokeratodermia
Erythrokeratodermia Ataxia

Spastic Quadriplegia

Spastic Quadriplegic Cerebral Palsy	Quadriplegic Infantile Cerebral Palsy
Tetraplegic Infantile Cerebral Palsy	Cerebral Palsy Spastic Quadriplegic
Quadriplegic Cerebral Palsy	Spastic Quadriplegia Cerebral Palsy
Spastic Tetraplegia Cerebral Palsy	Cerebral Palsy, Quadriplegic, Infantile
Cerebral Palsy With Spastic Tetraplegia	Congenital Spastic Quadriplegia
Spastic Tetraplegic Cerebral Palsy	Congenital Quadriplegia Nos
Tetraplegic Cerebral Palsy

Erythrokeratodermia Variabilis Et Progressiva 1

Erythrokeratodermia Variabilis	Erythrokeratodermia Variabilis Et Progressiva
Greither Disease	Ekv
Ekvp	PSEK
Erythrokeratodermia Variabilis With Erythema Gyratum Repens	Keratosis Palmoplantaris Transgrediens Et Progrediens
Transgrediens Et Progrediens Palmoplantar Keratoderma	EKVP1
Erythrokeratodermia, Progressive Symmetric	Erythrokeratodermia Figurata, Congenital Familial, In Plaques
Keratoderma Palmoplantaris Transgrediens	Keratosis Extremitatum Hereditaria Progrediens
Erythrokeratodermia Variabilis, Mendes Da Costa Type	Progressive Symmetric Erythrokeratodermia
Erythrokeratodermia Figurata Variabilis	Greither'S Disease
Ekv-P	Erythrokeratodermia Variabilis Of Mendes Da Costa
Progressive Symmetrical Erythrokeratoderma Of Gottron	Progressive Diffuse Ppk
Progressive Diffuse Palmoplantar Keratoderma	Transgrediens Et Progrediens Ppk
Darier-Gottron Disease	Erythrokeratodermia Progressiva Symmetrica
Progressive Symmetric Erythrokeratodermia, Gottron Type	Congenital Familial Erythrokeratodermia Figurata In Plaques
Erythrokeratodermia Progressive Symmetric	Erythrokeratodermia Variabilis Mendes Da Costa Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04327	ELOVL7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ELOVL7	VGNC	VGNC:72117
Felis catus	ELOVL7	VGNC	VGNC:61825
Mus musculus	ELOVL7	MGD	MGI:1921809
Rattus norvegicus	ELOVL7	RGD	RGD:1310560
Canis familiaris	ELOVL7	VGNC	VGNC:40325
Bos taurus	ELOVL7	VGNC	VGNC:28453

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