2. Gene
  3. TRIM59 - tripartite motif containing 59 Gene

TRIM59 - tripartite motif containing 59 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as MRF1; TSBF1; IFT80L; RNF104; TRIM57

Gene ID: 286827 | Gene type: protein coding

About TRIM59

Cytogenetic location: 3q25.33 Genomic coordinates (GRCh38): 3:160,435,503-160,449,786 (from NCBI)

This gene has 8 transcripts (splice variants), 130 orthologues and 1 paralogue. Broad expression in testis (RPKM 4.6), lymph node (RPKM 4.6) and 21 other tissues.

Summary

Predicted to enable ubiquitin protein Ligase activity. Acts upstream of or within negative regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to be located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

TRIM59 Products(1)

mRNA Protein Name
NM_173084.3 NP_775107.1 tripartite motif-containing protein 59

TRIM59 Protein Structure

zf-RING_2

zf-RING_2: Ring finger domain (9 - 60)

zf-B_box

zf-B_box: B-box zinc finger (95 - 133)

  • 0
  • 100
  • 200
  • 300
  • 403 a.a.
Protein Preferred Names Protein Names

tripartite motif-containing protein 59

RING finger protein 104

TRIM59 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TRIM59 Q8IWR1 NECAB2 Homo sapiens Q7Z6G3-2
Y2H Array
32296183
Intra
TRIM59 Q8IWR1 NECAB2 Homo sapiens Q7Z6G3-2
Y2H Prey Pooling
32296183
Intra
TRIM59 Q8IWR1 KRTAP13-3 Homo sapiens Q3SY46
Y2H Prey Pooling
32296183
Intra
TRIM59 Q8IWR1 KRTAP13-3 Homo sapiens Q3SY46
Y2H Array
32296183
Intra
TRIM59 Q8IWR1 NRM Homo sapiens Q8IXM6
Y2H Prey Pooling
25416956
Intra
TRIM59 Q8IWR1 NRM Homo sapiens Q8IXM6
Validated Y2H
32296183
Intra
TRIM59 Q8IWR1 NRM Homo sapiens Q8IXM6
Y2H Array
25416956
Intra
TRIM59 Q8IWR1 ZDHHC22 Homo sapiens Q8N966
Validated Y2H
32296183
Intra
TRIM59 Q8IWR1 ZDHHC22 Homo sapiens Q8N966
Y2H Array
25416956
Intra
TRIM59 Q8IWR1 ZDHHC22 Homo sapiens Q8N966
Y2H Array
29892012
Intra
TRIM59 Q8IWR1 ZDHHC22 Homo sapiens Q8N966
Validated Y2H
25416956
Intra
TRIM59 Q8IWR1 UBE2W Homo sapiens Q96FI0
Y2H Prey Pooling
32296183
Intra
TRIM59 Q8IWR1 UBE2W Homo sapiens Q96FI0
Validated Y2H
32296183
Intra
TRIM59 Q8IWR1 UBE2W Homo sapiens Q96FI0
Y2H Array
32296183
Intra
TRIM59 Q8IWR1 ANKRD33 Homo sapiens Q7Z3H0-1
Y2H Prey Pooling
32296183
Intra
TRIM59 Q8IWR1 ANKRD33 Homo sapiens Q7Z3H0-1
Y2H Array
32296183
Intra
TRIM59 Q8IWR1 MEI4 Homo sapiens A8MW99
Y2H Prey Pooling
32296183
Intra
TRIM59 Q8IWR1 MEI4 Homo sapiens A8MW99
Y2H Array
32296183
Intra
TRIM59 Q8IWR1 UBE2J2 Homo sapiens Q8N2K1
Validated Y2H
32296183
Intra
TRIM59 Q8IWR1 BLZF1 Homo sapiens Q9H2G9
Validated Y2H
32296183
Intra
TRIM59 Q8IWR1 BLZF1 Homo sapiens Q9H2G9
Y2H Array
32296183
Intra
TRIM59 Q8IWR1 BLZF1 Homo sapiens Q9H2G9
Y2H Prey Pooling
32296183
Intra
TRIM59 Q8IWR1 RASSF3 Homo sapiens Q86WH2
Y2H Array
32296183
Intra
TRIM59 Q8IWR1 RASSF3 Homo sapiens Q86WH2
Y2H Prey Pooling
32296183
Intra
TRIM59 Q8IWR1 MRPL12 Homo sapiens P52815
Y2H Prey Pooling
32296183
Intra
TRIM59 Q8IWR1 MRPL12 Homo sapiens P52815
Y2H Array
32296183
Intra
TRIM59 Q8IWR1 PLLP Homo sapiens Q9Y342
Validated Y2H
32296183
Intra
TRIM59 Q8IWR1 VTI1B Homo sapiens Q9UEU0
Validated Y2H
25416956
Intra
TRIM59 Q8IWR1 VTI1B Homo sapiens Q9UEU0
Validated Y2H
32296183
Intra
TRIM59 Q8IWR1 SEC22A Homo sapiens Q96IW7
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15059 TRIM59 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TRIM59 VGNC VGNC:47829
Felis catus TRIM59 VGNC VGNC:101467
Macaca mulatta TRIM59 VGNC VGNC:79887
Bos taurus TRIM59 VGNC VGNC:36344
Rattus norvegicus TRIM59 RGD RGD:1311956
Mus musculus TRIM59 MGD MGI:1914199