TRIM59 - tripartite motif containing 59 Gene

Homo sapiens

Also known as MRF1; TSBF1; IFT80L; RNF104; TRIM57

Gene ID: 286827 | Gene type: protein coding

About TRIM59

Cytogenetic location: 3q25.33 Genomic coordinates (GRCh38): 3:160,435,503-160,449,786 (from NCBI)

This gene has 8 transcripts (splice variants), 130 orthologues and 1 paralogue. Broad expression in testis (RPKM 4.6), lymph node (RPKM 4.6) and 21 other tissues.

Summary

Predicted to enable ubiquitin protein Ligase activity. Acts upstream of or within negative regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to be located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

TRIM59 Products(1)

mRNA	Protein	Name
NM_173084.3	NP_775107.1	tripartite motif-containing protein 59

TRIM59 Protein Structure

zf-RING_2

zf-B_box

0
100
200
300
403 a.a.

Protein Preferred Names

Protein Names

tripartite motif-containing protein 59

RING finger protein 104

TRIM59 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TRIM59	Q8IWR1	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Array	32296183
Intra	TRIM59	Q8IWR1	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Prey Pooling	32296183
Intra	TRIM59	Q8IWR1	KRTAP13-3	Homo sapiens	Q3SY46	Y2H Prey Pooling	32296183
Intra	TRIM59	Q8IWR1	KRTAP13-3	Homo sapiens	Q3SY46	Y2H Array	32296183
Intra	TRIM59	Q8IWR1	NRM	Homo sapiens	Q8IXM6	Y2H Prey Pooling	25416956
Intra	TRIM59	Q8IWR1	NRM	Homo sapiens	Q8IXM6	Validated Y2H	32296183
Intra	TRIM59	Q8IWR1	NRM	Homo sapiens	Q8IXM6	Y2H Array	25416956
Intra	TRIM59	Q8IWR1	ZDHHC22	Homo sapiens	Q8N966	Validated Y2H	32296183
Intra	TRIM59	Q8IWR1	ZDHHC22	Homo sapiens	Q8N966	Y2H Array	25416956
Intra	TRIM59	Q8IWR1	ZDHHC22	Homo sapiens	Q8N966	Y2H Array	29892012
Intra	TRIM59	Q8IWR1	ZDHHC22	Homo sapiens	Q8N966	Validated Y2H	25416956
Intra	TRIM59	Q8IWR1	UBE2W	Homo sapiens	Q96FI0	Y2H Prey Pooling	32296183
Intra	TRIM59	Q8IWR1	UBE2W	Homo sapiens	Q96FI0	Validated Y2H	32296183
Intra	TRIM59	Q8IWR1	UBE2W	Homo sapiens	Q96FI0	Y2H Array	32296183
Intra	TRIM59	Q8IWR1	ANKRD33	Homo sapiens	Q7Z3H0-1	Y2H Prey Pooling	32296183
Intra	TRIM59	Q8IWR1	ANKRD33	Homo sapiens	Q7Z3H0-1	Y2H Array	32296183
Intra	TRIM59	Q8IWR1	MEI4	Homo sapiens	A8MW99	Y2H Prey Pooling	32296183
Intra	TRIM59	Q8IWR1	MEI4	Homo sapiens	A8MW99	Y2H Array	32296183
Intra	TRIM59	Q8IWR1	UBE2J2	Homo sapiens	Q8N2K1	Validated Y2H	32296183
Intra	TRIM59	Q8IWR1	BLZF1	Homo sapiens	Q9H2G9	Validated Y2H	32296183
Intra	TRIM59	Q8IWR1	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	32296183
Intra	TRIM59	Q8IWR1	BLZF1	Homo sapiens	Q9H2G9	Y2H Prey Pooling	32296183
Intra	TRIM59	Q8IWR1	RASSF3	Homo sapiens	Q86WH2	Y2H Array	32296183
Intra	TRIM59	Q8IWR1	RASSF3	Homo sapiens	Q86WH2	Y2H Prey Pooling	32296183
Intra	TRIM59	Q8IWR1	MRPL12	Homo sapiens	P52815	Y2H Prey Pooling	32296183
Intra	TRIM59	Q8IWR1	MRPL12	Homo sapiens	P52815	Y2H Array	32296183
Intra	TRIM59	Q8IWR1	PLLP	Homo sapiens	Q9Y342	Validated Y2H	32296183
Intra	TRIM59	Q8IWR1	VTI1B	Homo sapiens	Q9UEU0	Validated Y2H	25416956
Intra	TRIM59	Q8IWR1	VTI1B	Homo sapiens	Q9UEU0	Validated Y2H	32296183
Intra	TRIM59	Q8IWR1	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15059	TRIM59 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TRIM59	VGNC	VGNC:47829
Felis catus	TRIM59	VGNC	VGNC:101467
Macaca mulatta	TRIM59	VGNC	VGNC:79887
Bos taurus	TRIM59	VGNC	VGNC:36344
Rattus norvegicus	TRIM59	RGD	RGD:1311956
Mus musculus	TRIM59	MGD	MGI:1914199

Name
Email *

	Sorry, but the email address you supplied was invalid.