Arg2 - arginase type II Gene

Mus musculus

Also known as AII

Gene ID: 11847 | Gene type: protein coding

About Arg2

Summary

Predicted to enable Arginase activity; manganese ion binding activity; and nitric-oxide synthase binding activity. Involved in several processes, including negative regulation of CD4-positive, alpha-beta T cell proliferation; negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process; and negative regulation of cytokine production. Acts upstream of or within striated muscle contraction and ureteric bud development. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ARG2 (Arginase 2). [provided by Alliance of Genome Resources, Apr 2022]

Arg2 Products(1)

mRNA	Protein	Name
NM_009705.3	NP_033835.1	arginase-2, mitochondrial precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of CD4-positive, alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	25009204	MGI
involved in negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process	IMP IMP: Inferred from mutant phenotype	27745970	MGI
involved in negative regulation of chemokine (C-C motif) ligand 4 production	IMP IMP: Inferred from mutant phenotype	27074721	MGI
involved in negative regulation of chemokine (C-C motif) ligand 5 production	IMP IMP: Inferred from mutant phenotype	27074721	MGI
involved in negative regulation of defense response to bacterium	IMP IMP: Inferred from mutant phenotype	27074721	MGI
involved in negative regulation of interleukin-13 production	IMP IMP: Inferred from mutant phenotype	27214549	MGI
involved in negative regulation of interleukin-17 production	IMP IMP: Inferred from mutant phenotype	27214549	MGI
involved in negative regulation of macrophage inflammatory protein 1 alpha production	IMP IMP: Inferred from mutant phenotype	27074721	MGI
involved in negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	27074721	MGI
involved in negative regulation of type 2 immune response	IMP IMP: Inferred from mutant phenotype	27214549	MGI
involved in regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	27074721	MGI
involved in regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	27214549	MGI
acts upstream of or within striated muscle contraction	IMP IMP: Inferred from mutant phenotype	16537391	MGI
involved in ureteric bud development	IEP IEP: Inferred from expression pattern	16545622	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	25009204	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

arginase-2, mitochondrial

arginase II	kidney-type arginase
non-hepatic arginase	type II arginase

Recombinant Arg2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72090	Arginase-2/ARG2 Protein, Mouse (His-SUMO)	O08691 (V23-I354)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112885B	nor-NOHA monoacetate	Inhibitor	99.96%	Unkown
HY-112885C	nor-NOHA dihydrochloride		98.85%	Unkown
HY-P4750	Acetyl-(D-Arg2)-GRF (1-29) amide (human)	Antagonist	99.67%	Unkown
HY-112885A	nor-NOHA acetate		≥99.0%	Unkown
HY-RS00908	ARG2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-112885	nor-NOHA		/	Unkown
HY-P10555	(D-Arg2, Sar 4)-Dermorphin (1-4)	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Arg2	NCBI	NCBI:384

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