nor-NOHA (Synonyms: Nω-Hydroxy-nor-L-arginine)

Cat. No.: HY-112885: FAQs
Data Sheet Handling Instructions

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nor-NOHA is a selective and reversible arginase inhibitor. nor-NOHA induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA has anti-leukemic activity. nor-NOHA can used in study of endothelial dysfunction, immunosuppression and metabolism.

For research use only. We do not sell to patients.

nor-NOHA Chemical Structure

CAS No. : 189302-40-7

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Other In-stock Forms of nor-NOHA:

nor-NOHA acetate

Other Forms of nor-NOHA:

2 Publications Citing Use of MCE nor-NOHA

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

nor-NOHA (0.1-1 mM, 72 h) induces apoptosis in a dose-dependent manner under hypoxia (1.5% O2) in K562 cells^[1]. nor-NOHA (1 mM, 72 h) attenuates hypoxia-mediated resistance towards imatinib in K562 or KCL22 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

nor-NOHA (100 mg/kg, i.v., once time) induces a significant reduction of infarct size in male Sprague-Dawley rats^[2]. nor-NOHA (100 mg/kg, i.v., once time) increases plasma citrulline and nitrite levels and decreases the ornithine plasma levels in male Sprague-Dawley rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

176.17

Formula

C₅H₁₂N₄O₃

CAS No.

189302-40-7

SMILES

O=C(O)[C@@H](N)CCNC(NO)=N

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O : 250 mg/mL (1419.08 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.6763 mL	28.3817 mL	56.7634 mL
5 mM	1.1353 mL	5.6763 mL	11.3527 mL
10 mM	0.5676 mL	2.8382 mL	5.6763 mL

View the Complete Stock Solution Preparation Table

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

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Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ng KP, et al. The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target. PLoS One. 2018 Oct 11;13(10):e0205254. [Content Brief]

[2]. Jung C, et al. Arginase inhibition mediates cardioprotection during ischaemia-reperfusion. Cardiovasc Res. 2010 Jan 1;85(1):147-54. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.6763 mL	28.3817 mL	56.7634 mL	141.9084 mL
	5 mM	1.1353 mL	5.6763 mL	11.3527 mL	28.3817 mL
	10 mM	0.5676 mL	2.8382 mL	5.6763 mL	14.1908 mL
	15 mM	0.3784 mL	1.8921 mL	3.7842 mL	9.4606 mL
	20 mM	0.2838 mL	1.4191 mL	2.8382 mL	7.0954 mL
	25 mM	0.2271 mL	1.1353 mL	2.2705 mL	5.6763 mL
	30 mM	0.1892 mL	0.9461 mL	1.8921 mL	4.7303 mL
	40 mM	0.1419 mL	0.7095 mL	1.4191 mL	3.5477 mL
	50 mM	0.1135 mL	0.5676 mL	1.1353 mL	2.8382 mL
	60 mM	0.0946 mL	0.4730 mL	0.9461 mL	2.3651 mL
	80 mM	0.0710 mL	0.3548 mL	0.7095 mL	1.7739 mL
	100 mM	0.0568 mL	0.2838 mL	0.5676 mL	1.4191 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

nor-NOHA Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

nor-NOHA189302-40-7Nω-Hydroxy-nor-L-arginineApoptosisArginaseSprague-DawleyK562,KCL22apoptosisanti-leukemic activityendothelial dysfunctionimmunosuppression and metabolismInhibitorinhibitorinhibit

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