SFXN2 - sideroflexin 2 Gene

Homo sapiens

Also known as SLC56A2

Gene ID: 118980 | Gene type: protein coding

About SFXN2

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:102,714,636-102,743,492 (from NCBI)

This gene has 13 transcripts (splice variants), 205 orthologues and 4 paralogues. Broad expression in kidney (RPKM 25.3), thyroid (RPKM 4.8) and 16 other tissues.

Summary

Predicted to enable serine transmembrane transporter activity. Involved in mitochondrial transmembrane transport. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

SFXN2 Products(2)

mRNA	Protein	Name
NM_001350989.2	NP_001337918.1	sideroflexin-2
NM_178858.6	NP_849189.1	sideroflexin-2

SFXN2 Protein Structure

Mtc

0
100
200
300
322 a.a.

Protein Preferred Names

Protein Names

sideroflexin-2

SFXN2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SFXN2	Q96NB2	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	SFXN2	Q96NB2	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	SFXN2	Q96NB2	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	SFXN2	Q96NB2	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	SFXN2	Q96NB2	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	SFXN2	Q96NB2	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	SFXN2	Q96NB2	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183
Intra	SFXN2	Q96NB2	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	SFXN2	Q96NB2	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	SFXN2	Q96NB2	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	SFXN2	Q96NB2	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	SFXN2	Q96NB2	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Combined Oxidative Phosphorylation Deficiency 18

Growth And Developmental Delay-Hypotonia-Vision Impairment-Lactic Acidosis Syndrome	COXPD18
Combined Oxidative Phosphorylation Deficiency, Type 18

Combined Oxidative Phosphorylation Deficiency 7

COXPD7	Combined Oxidative Phosphorylation Defect Type 7
Severe C12orf65-Related Combined Oxidative Phosphorylation Defect	Severe C12orf65-Related Coxpd
Combined Oxidative Phosphorylation Deficiency, Type 7

Sengers Syndrome

Mitochondrial Dna Depletion Syndrome 10	Cardiomyopathy And Cataract
Cataract And Cardiomyopathy	MTDPS10
Congenital Cataract-Hypertrophic Cardiomyopathy-Mitochondrial Myopathy Syndrome	Cardiomyopathic Mitochondrial Dna Depletion Syndrome 10
Senger Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12786	SFXN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SFXN2	MGD	MGI:2137678
Bos taurus	SFXN2	VGNC	VGNC:34531
Rattus norvegicus	SFXN2	RGD	RGD:1306131
Felis catus	SFXN2	VGNC	VGNC:65070
Canis familiaris	SFXN2	VGNC	VGNC:46088

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