PDZK1IP1 - PDZK1 interacting protein 1 Gene

Homo sapiens

Also known as DD96; SPAP; MAP17

Gene ID: 10158 | Gene type: protein coding

About PDZK1IP1

Cytogenetic location: 1p33 Genomic coordinates (GRCh38): 1:47,183,582-47,190,036 (from NCBI)

This gene has 4 transcripts (splice variants), 118 orthologues and 1 paralogue. Biased expression in kidney (RPKM 568.2), gall bladder (RPKM 87.6) and 3 other tissues.

Summary

Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

PDZK1IP1 Products(1)

mRNA	Protein	Name
NM_005764.4	NP_005755.1	PDZK1-interacting protein 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

PDZK1-interacting protein 1

17 kDa membrane-associated protein

PDZK1IP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PDZK1IP1	Q13113	GRM2	Homo sapiens	Q14416	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	RTP2	Homo sapiens	Q5QGT7	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	SLC35B4	Homo sapiens	Q969S0	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	PLPP4	Homo sapiens	Q5VZY2	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	TMEM109	Homo sapiens	Q9BVC6	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	PDZK1IP1	Q13113	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	PDZK1IP1	Q13113	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	PDZK1IP1	Q13113	PSEN1	Homo sapiens	P49768-2	Y2H Array	32814053
Intra	PDZK1IP1	Q13113	PSEN1	Homo sapiens	P49768-2	Validated Y2H	32814053
Intra	PDZK1IP1	Q13113	PSEN1	Homo sapiens	P49768-2	Y2H Pooling	32814053
Intra	PDZK1IP1	Q13113	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	PDZK1IP1	Q13113	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	PDZK1IP1	Q13113	PLPP6	Homo sapiens	Q8IY26	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	AIG1	Homo sapiens	Q9NVV5-2	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	TMEM86A	Homo sapiens	Q8N2M4	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	NRAC	Homo sapiens	Q8N912	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	PGAP2	Homo sapiens	Q9UHJ9-5	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	TMEM97	Homo sapiens	Q5BJF2	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	TSPO2	Homo sapiens	Q5TGU0	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	CLDN19	Homo sapiens	Q8N6F1-2	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	TMEM203	Homo sapiens	Q969S6	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	TMEM107	Homo sapiens	Q6UX40	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	PDZK1IP1	Q13113	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	PDZK1IP1	Q13113	MYADM	Homo sapiens	Q96S97	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	APP	Homo sapiens	P05067-2	Validated Y2H	32814053
Intra	PDZK1IP1	Q13113	APP	Homo sapiens	P05067-2	Y2H Pooling	32814053
Intra	PDZK1IP1	Q13113	APP	Homo sapiens	P05067-2	Y2H Array	32814053
Intra	PDZK1IP1	Q13113	TMEM39B	Homo sapiens	Q9GZU3-4	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	TMEM39B	Homo sapiens	Q9GZU3-4	Y2H Prey Pooling	32296183
Intra	PDZK1IP1	Q13113	TMEM39B	Homo sapiens	Q9GZU3-4	Y2H Array	32296183
Intra	PDZK1IP1	Q13113	PSEN2	Homo sapiens	P49810	Y2H Pooling	32814053
Intra	PDZK1IP1	Q13113	PSEN2	Homo sapiens	P49810	Validated Y2H	32814053
Intra	PDZK1IP1	Q13113	PSEN2	Homo sapiens	P49810	Y2H Array	32814053
Intra	PDZK1IP1	Q13113	SLC5A2	Homo sapiens	P31639	3D-EM	38057552
Intra	PDZK1IP1	Q13113	PRKN	Homo sapiens	O60260-5	Validated Y2H	32814053
Intra	PDZK1IP1	Q13113	PRKN	Homo sapiens	O60260-5	Y2H Array	32814053
Intra	PDZK1IP1	Q13113	PRKN	Homo sapiens	O60260-5	Y2H Pooling	32814053
Intra	PDZK1IP1	Q13113	TMEM14C	Homo sapiens	Q9P0S9	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	TOR1A	Homo sapiens	O14656-2	Validated Y2H	32814053
Intra	PDZK1IP1	Q13113	TOR1A	Homo sapiens	O14656-2	Y2H Array	32814053
Intra	PDZK1IP1	Q13113	TOR1A	Homo sapiens	O14656-2	Y2H Pooling	32814053
Intra	PDZK1IP1	Q13113	CYBC1	Homo sapiens	Q9BQA9	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	STX12	Homo sapiens	Q86Y82	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	TMEM14A	Homo sapiens	Q9Y6G1	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	EMC6	Homo sapiens	Q9BV81	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	TMEM140	Homo sapiens	Q9NV12	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	PINK1	Homo sapiens	Q9BXM7	Y2H Array	32814053
Intra	PDZK1IP1	Q13113	PINK1	Homo sapiens	Q9BXM7	Y2H Pooling	32814053
Intra	PDZK1IP1	Q13113	PINK1	Homo sapiens	Q9BXM7	Validated Y2H	32814053
Intra	PDZK1IP1	Q13113	FAM3C	Homo sapiens	Q92520	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	TMEM101	Homo sapiens	Q96IK0	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	GALNT15	Homo sapiens	Q8N3T1	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	AGR3	Homo sapiens	Q8TD06	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	PDZK1IP1	Q13113	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	PDZK1IP1	Q13113	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	PDZK1IP1	Q13113	GIMAP5	Homo sapiens	Q96F15	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	SFXN2	Homo sapiens	Q96NB2	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	TMEM65	Homo sapiens	Q6PI78	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	ERG28	Homo sapiens	Q9UKR5	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	UCHL1	Homo sapiens	P09936	Validated Y2H	32814053
Intra	PDZK1IP1	Q13113	UCHL1	Homo sapiens	P09936	Y2H Array	32814053
Intra	PDZK1IP1	Q13113	UCHL1	Homo sapiens	P09936	Y2H Pooling	32814053
Intra	PDZK1IP1	Q13113	VAMP3	Homo sapiens	Q15836	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	PDZK1IP1	Q13113	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	PDZK1IP1	Q13113	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	PDZK1IP1	Q13113	YIPF6	Homo sapiens	Q96EC8	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	PDZK1IP1	Q13113	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	PDZK1IP1	Q13113	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	PDZK1IP1	Q13113	PEX16	Homo sapiens	Q9Y5Y5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Supraglottis Neoplasm

Neoplasm Of Supraglottis

Supraglottic Tumor

Spinal Muscular Atrophy, Type Iv

SMA4	Spinal Muscular Atrophy, Adult Form
Spinal Muscular Atrophy 4	Spinal Muscular Atrophy-4
Adult Spinal Muscular Atrophy	Spinal Muscular Atrophy, Proximal, Adult, Autosomal Recessive
Proximal Spinal Muscular Atrophy Type 4	Sma Type 4
Sma Type Iv	Sma-Iv
Sma Iv	Spinal Muscular Atrophy Adult Form
Spinal Muscular Atrophy Proximal Adult Autosomal Recessive	Spinal Muscular Atrophy Type Iv
Atrophy, Muscular, Spinal, Type Iv	Myelopathic Muscular Atrophy

Laryngeal Benign Neoplasm

Laryngeal Tumor	Larynx Neoplasm
Neoplasm Of Larynx	Laryngeal Cancer
Laryngeal Carcinoma	Cancer Of Larynx

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10306	PDZK1IP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PDZK1IP1	RGD	RGD:620952
Bos taurus	PDZK1IP1	VGNC	VGNC:32730
Canis familiaris	PDZK1IP1	VGNC	VGNC:44404
Mus musculus	PDZK1IP1	MGD	MGI:1914432
Felis catus	PDZK1IP1	VGNC	VGNC:64106

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