GSTO2 - glutathione S-transferase omega 2 Gene

Homo sapiens

Also known as GSTO 2-2; bA127L20.1

Gene ID: 119391 | Gene type: protein coding

About GSTO2

Cytogenetic location: 10q25.1 Genomic coordinates (GRCh38): 10:104,269,184-104,304,950 (from NCBI)

This gene has 7 transcripts (splice variants), 542 orthologues and 14 paralogues. Broad expression in skin (RPKM 2.1), testis (RPKM 1.8) and 21 other tissues.

Summary

The protein encoded by this gene is an omega class Glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]

GSTO2 Products(4)

mRNA	Protein	Name
NM_001191013.2	NP_001177942.1	glutathione S-transferase omega-2 isoform 2
NM_001191014.2	NP_001177943.1	glutathione S-transferase omega-2 isoform 3
NM_001191015.2	NP_001177944.1	glutathione S-transferase omega-2 isoform 4
NM_183239.2	NP_899062.1	glutathione S-transferase omega-2 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables glutathione dehydrogenase (ascorbate) activity	IDA IDA: Inferred from direct assay	15970797	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables oxidoreductase activity	IDA IDA: Inferred from direct assay	15970797	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in L-ascorbic acid metabolic process	IDA IDA: Inferred from direct assay	15970797	GOA
involved in cellular response to arsenic-containing substance	IDA IDA: Inferred from direct assay	15970797	GOA
involved in xenobiotic metabolic process	IDA IDA: Inferred from direct assay	15970797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSTO2 Protein Structure

GST_N_3

GST_C_2

0
100
200
243 a.a.

Protein Preferred Names

Protein Names

glutathione S-transferase omega-2

GSTO-2

GSTO2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GSTO2	Q9H4Y5	GSTO2	Homo sapiens	Q9H4Y5	Validated Y2H	32296183
Intra	GSTO2	Q9H4Y5	GSTO2	Homo sapiens	Q9H4Y5	Y2H Array	25416956
Intra	GSTO2	Q9H4Y5	GSTO2	Homo sapiens	Q9H4Y5	Y2H Array	32296183
Intra	GSTO2	Q9H4Y5	MUM1	Homo sapiens	Q9H6H2	Validated Y2H	25416956
Intra	GSTO2	Q9H4Y5	GSTO2	Homo sapiens	Q9H4Y5	Y2H Prey Pooling	32296183
Intra	GSTO2	Q9H4Y5	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	GSTO2	Q9H4Y5	TFAP2A	Homo sapiens	P05549	Y2H Prey Pooling	25416956
Intra	GSTO2	Q9H4Y5	TFAP2A	Homo sapiens	P05549	Y2H Array	25416956
Intra	GSTO2	Q9H4Y5	MUM1	Homo sapiens	Q9H6H2	Y2H Prey Pooling	25416956
Intra	GSTO2	Q9H4Y5	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	GSTO2	Q9H4Y5	PFDN5	Homo sapiens	Q99471	Y2H Array	32296183
Intra	GSTO2	Q9H4Y5	PFDN5	Homo sapiens	Q99471	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Chronic Closed-Angle Glaucoma

Anatomical Narrow Angle Glaucoma	Chronic Angle-Closure Glaucoma
Chronic Narrow Angle Glaucoma	Secondary Angle-Closure Glaucoma - Synechial

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05885	GSTO2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GSTO2	VGNC	VGNC:110343
Mus musculus	GSTO2	MGD	MGI:1915464
Macaca mulatta	GSTO2	VGNC	VGNC:106055
Bos taurus	GSTO2	VGNC	VGNC:29687
Felis catus	GSTO2	VGNC	VGNC:62732
Rattus norvegicus	GSTO2	RGD	RGD:1310764

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