Phb2 - prohibitin 2 Gene

Mus musculus

Also known as BAP; REA; Bap37; Bcap37

Gene ID: 12034 | Gene type: protein coding

About Phb2

Summary

Enables sphingolipid binding activity. Involved in several processes, including CD40 signaling pathway; regulation of gene expression; and regulation of phosphate metabolic process. Acts upstream of or within several processes, including mammary gland development; negative regulation of intracellular Estrogen Receptor signaling pathway; and negative regulation of mammary gland epithelial cell proliferation. Located in cell surface; mitochondrial inner membrane; and nucleus. Part of inner mitochondrial membrane protein complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and respiratory system. Orthologous to human PHB2 (prohibitin 2). [provided by Alliance of Genome Resources, Apr 2022]

Phb2 Products(1)

mRNA	Protein	Name
NM_007531.2	NP_031557.2	prohibitin-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12878603	MGI
enables sphingolipid binding	IDA IDA: Inferred from direct assay	20959514	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in B cell activation	IDA IDA: Inferred from direct assay	23241883	MGI
acts upstream of estrogen receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17065319	MGI
acts upstream of or within mammary gland alveolus development	IMP IMP: Inferred from mutant phenotype	17065319	MGI
acts upstream of or within mammary gland branching involved in thelarche	IMP IMP: Inferred from mutant phenotype	17065319	MGI
acts upstream of mammary gland epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	17065319	MGI
involved in mitophagy	IDA IDA: Inferred from direct assay	28017329	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15140878	MGI
acts upstream of or within negative regulation of intracellular estrogen receptor signaling pathway	IGI IGI: Inferred from genetic interaction	17785450	MGI
acts upstream of or within negative regulation of intracellular estrogen receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17065319	MGI
acts upstream of or within negative regulation of mammary gland epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	17065319	MGI
involved in positive regulation of immunoglobulin production	IDA IDA: Inferred from direct assay	23241883	MGI
involved in positive regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	23241883	MGI
acts upstream of or within regulation of branching involved in mammary gland duct morphogenesis	IMP IMP: Inferred from mutant phenotype	17065319	MGI
involved in regulation of cardiolipin metabolic process	IMP IMP: Inferred from mutant phenotype	24856930	MGI
involved in regulation of cytochrome-c oxidase activity	IMP IMP: Inferred from mutant phenotype	20959514	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	22417827	MGI
part of inner mitochondrial membrane protein complex	IDA IDA: Inferred from direct assay	24856930	MGI
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	11302691	MGI
part of mitochondrial prohibitin complex	IPI IPI: Inferred from physical interaction	20959514	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	14651853	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15140878	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

prohibitin-2

B-cell receptor-associated protein 37	B-cell receptor-associated protein BAP37
repressor of estrogen receptor activity

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114989	Fluorizoline	Inducer	99.77%	Unkown
HY-152093	YL-939	Inhibitor	98.97%	Unkown
HY-117113	JI051	Inhibitor	≥98.0%	Unkown
HY-124484	JI130	Inhibitor	99.01%	Unkown
HY-162904	BPU17		/	Unkown
HY-RS10408	PHB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Phb2	NCBI	NCBI:11331
Macaca fascicularis	Phb2	NCBI	NCBI:102136314

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