Bcl2a1a - B cell leukemia/lymphoma 2 related protein A1a Gene

Mus musculus

Also known as A1; Bfl-1; Hbpa1; Bcl2a1

Gene ID: 12044 | Gene type: protein coding

About Bcl2a1a

Chromosome 9: 88,838,953-88,844,472 forward strand.GRCm39:CM001002.3

This gene has 1 transcript (splice variant), 112 orthologues, 10 paralogues and is associated with 5 phenotypes. Biased expression in spleen adult (RPKM 7.1), thymus adult (RPKM 4.6) and 13 other tissues.

Summary

Predicted to enable protein heterodimerization activity and protein homodimerization activity. Involved in negative regulation of apoptotic process. Acts upstream of or within B cell homeostasis and negative regulation of B cell apoptotic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrial outer membrane. Is expressed in several structures, including bone; central nervous system; heart; hemolymphoid system; and respiratory system. Orthologous to human BCL2A1 (BCL2 related protein A1). [provided by Alliance of Genome Resources, Apr 2022]

Bcl2a1a Products(1)

mRNA	Protein	Name
NM_009742.3	NP_033872.1	bcl-2-related protein A1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11888890	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of B cell apoptotic process	IDA IDA: Inferred from direct assay	14625542	MGI
acts upstream of or within B cell homeostasis	IDA IDA: Inferred from direct assay	12928432	MGI
acts upstream of or within negative regulation of B cell apoptotic process	IDA IDA: Inferred from direct assay	14625542	MGI
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	11888890	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bcl2a1a Protein Structure

BCL

0
100
172 a.a.

Protein Preferred Names

Protein Names

bcl-2-related protein A1

A1-A	hemopoietic-specific early response protein
protein BFL-1

Bcl2a1a Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Bcl2a1	Q07440	BID	Homo sapiens	P55957	SPR	15694340
Intra	Bcl2a1	Q07440	Bmf	Mus musculus	Q91ZE9	X-Ray Diffraction	18462686
Intra	Bcl2a1	Q07440	Bmf	Mus musculus	Q91ZE9	ITC	18462686
Intra	Bcl2a1	Q07440	Bbc3	Mus musculus	Q99ML1	ITC	18462686
Intra	Bcl2a1	Q07440	Bbc3	Mus musculus	Q99ML1	X-Ray Diffraction	18462686
Intra	Bcl2a1	Q07440	Bid	Mus musculus	P70444	ITC	18462686
Intra	Bcl2a1	Q07440	Bid	Mus musculus	P70444	X-Ray Diffraction	18462686
Intra	Bcl2a1	Q07440	Bak1	Mus musculus	O08734	ITC	18462686
Intra	Bcl2a1	Q07440	Bak1	Mus musculus	O08734	X-Ray Diffraction	18462686

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01420	Bcl2a1a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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