Bglap - bone gamma carboxyglutamate protein Gene

Mus musculus

Also known as OC; BGP; OG1; mOC-A; Bglap1

Gene ID: 12096 | Gene type: protein coding

About Bglap

Summary

This gene encodes one of the most abundant non-collagenous proteins in bone tissue that is localized to the mineralized matrix of bone. The encoded preproprotein undergoes proteolytic processing and post-translational gamma carboxylation to generate a mature, calcium-binding protein. Mice lacking the encoded protein develop abnormalities of bone remodelling. This gene is located adjacent to two Other osteocalcin-related genes on chromosome 3. [provided by RefSeq, Oct 2015]

Bglap Products(1)

mRNA	Protein	Name
NM_007541.3	NP_031567.1	osteocalcin preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables hormone activity	IDA IDA: Inferred from direct assay	17693256	MGI
enables hormone activity	IMP IMP: Inferred from mutant phenotype	20655470	MGI
enables structural constituent of bone	IMP IMP: Inferred from mutant phenotype	8684484	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in brain development	IDA IDA: Inferred from direct assay	24074871	MGI
involved in brain development	IMP IMP: Inferred from mutant phenotype	24074871	MGI
acts upstream of or within cellular response to BMP stimulus	IDA IDA: Inferred from direct assay	21324897	MGI
involved in cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	17693256	MGI
involved in cellular response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	17693256	MGI
involved in cognition	IDA IDA: Inferred from direct assay	28851741	MGI
involved in cognition	IMP IMP: Inferred from mutant phenotype	28851741	MGI
involved in glucose homeostasis	IDA IDA: Inferred from direct assay	17693256	MGI
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	17693256	MGI
involved in learning or memory	IMP IMP: Inferred from mutant phenotype	24074871	MGI
involved in negative regulation of bone development	IMP IMP: Inferred from mutant phenotype	8684484	MGI
involved in positive regulation of neurotransmitter secretion	IDA IDA: Inferred from direct assay	24074871	MGI
involved in positive regulation of neurotransmitter secretion	IMP IMP: Inferred from mutant phenotype	24074871	MGI
involved in regulation of testosterone biosynthetic process	IDA IDA: Inferred from direct assay	21333348	MGI
involved in regulation of testosterone biosynthetic process	IMP IMP: Inferred from mutant phenotype	21333348	MGI
involved in type B pancreatic cell proliferation	IDA IDA: Inferred from direct assay	17693256	MGI
involved in type B pancreatic cell proliferation	IMP IMP: Inferred from mutant phenotype	17693256	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15030764	MGI
is active in extracellular region	IDA IDA: Inferred from direct assay	20655470	MGI
located in extracellular region	IDA IDA: Inferred from direct assay	21324897	MGI
is active in extracellular region	IMP IMP: Inferred from mutant phenotype	20655470	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

osteocalcin

bone Gla protein	bone gamma carboxyglutamate protein 1
gamma-carboxyglutamic acid-containing protein

Recombinant Bglap Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72103	BGLAP Protein, Mouse (His-SUMO)	P86546 (Y50-I95)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01488	BGLAP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bglap	NCBI	NCBI:632
Rattus norvegicus	Bglap	NCBI	NCBI:25295

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