FOXN4 - forkhead box N4 Gene

Homo sapiens

Gene ID: 121643 | Gene type: protein coding

About FOXN4

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:109,277,978-109,309,284 (from NCBI)

This gene has 4 transcripts (splice variants), 221 orthologues and 2 paralogues. Restricted expression toward testis (RPKM 2.5).

Summary

Members of the winged-helix/forkhead family of transcription factors, such as FOXN4, are characterized by a 110-amino acid DNA-binding domain that can fold into a variant of the helix-turn-helix motif consisting of 3 alpha helices flanked by 2 large loops or wings. These transcription factors are involved in a variety of biologic processes as key regulators in development and metabolism (Li et al., 2004 [PubMed 15363391]).[supplied by OMIM, Mar 2008]

FOXN4 Products(1)

mRNA	Protein	Name
NM_213596.3	NP_998761.2	forkhead box protein N4

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22323600	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	27107012	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXN4 Protein Structure

Forkhead

0
100
200
300
400
517 a.a.

Protein Preferred Names

Protein Names

forkhead box protein N4

forkhead/winged helix transcription factor FOXN4

FOXN4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FOXN4	Q96NZ1	AMY1A	Homo sapiens	P0DTE7	Anti Tag CoIP	33961781
Intra	FOXN4	Q96NZ1	AMY1A	Homo sapiens	P0DTE7	Anti Tag CoIP	28514442
Intra	FOXN4	Q96NZ1	FHL3	Homo sapiens	Q13643	Validated Y2H	27107012
Intra	FOXN4	Q96NZ1	RFX2	Homo sapiens	P48378	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lymphedema-Distichiasis Syndrome

Lymphedema With Distichiasis	Lymphedema-Distichiasis Syndrome With Renal Disease And Diabetes Mellitus
LPHDST	Distichiasis-Lymphedema Syndrome
Lymphedema Distichiasis Syndrome	Hereditary Lymphedema-Distichiasis Syndrome
Lymphedema Distichiasis

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05068	FOXN4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FOXN4	VGNC	VGNC:62342
Rattus norvegicus	FOXN4	RGD	RGD:1306389
Macaca mulatta	FOXN4	VGNC	VGNC:82146
Canis familiaris	FOXN4	VGNC	VGNC:40962
Mus musculus	FOXN4	MGD	MGI:2151057
Bos taurus	FOXN4	VGNC	VGNC:29097

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