Bmpr2 - bone morphogenetic protein receptor, type II (serine/threonine kinase) Gene

Mus musculus

Also known as BMP-2; BRK-3; BMPR-2; BMPRII; BMPR-II; Gm20272; 2610024H22Rik

Gene ID: 12168 | Gene type: protein coding

About Bmpr2

Chromosome 1: 59,802,559-59,918,173 forward strand.GRCm39:CM000994.3

This gene has 3 transcripts (splice variants), 265 orthologues, 11 paralogues and is associated with 44 phenotypes. Broad expression in lung adult (RPKM 22.1), frontal lobe adult (RPKM 8.3) and 19 other tissues.

Summary

This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type II receptor that binds extracellular BMPs and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream to activate SMAD transcriptional regulators. This signaling is important during embryonic development. Mutations in this gene can cause pulmonary hypertension. [provided by RefSeq, Mar 2013]

Bmpr2 Products(1)

mRNA	Protein	Name
NM_007561.4	NP_031587.1	bone morphogenetic protein receptor type-2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables BMP binding	IDA IDA: Inferred from direct assay	21976273	MGI
enables BMP receptor activity	IDA IDA: Inferred from direct assay	21976273	MGI
enables BMP receptor activity	IMP IMP: Inferred from mutant phenotype	26774823	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16923969	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	21976273	MGI
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	11714695	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in BMP signaling pathway	IDA IDA: Inferred from direct assay	21976273	MGI
acts upstream of or within BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	17472960	MGI
involved in BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	18552156	MGI
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	15542835	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	10772805	MGI
involved in aortic valve development	IMP IMP: Inferred from mutant phenotype	12441304	MGI
involved in artery development	IMP IMP: Inferred from mutant phenotype	19903896	MGI
involved in atrial septum morphogenesis	IMP IMP: Inferred from mutant phenotype	19409885	MGI
NOT involved in atrioventricular valve morphogenesis	IMP IMP: Inferred from mutant phenotype	12441304	MGI
involved in blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	19903896	MGI
NOT involved in cardiac muscle tissue development	IMP IMP: Inferred from mutant phenotype	19409885	MGI
involved in endocardial cushion development	IMP IMP: Inferred from mutant phenotype	12441304	MGI
acts upstream of or within limb development	IGI IGI: Inferred from genetic interaction	23610558	MGI
involved in lung alveolus development	IMP IMP: Inferred from mutant phenotype	18552156	MGI
involved in lymphangiogenesis	IMP IMP: Inferred from mutant phenotype	19903896	MGI
involved in lymphatic endothelial cell differentiation	IMP IMP: Inferred from mutant phenotype	19903896	MGI
acts upstream of or within maternal placenta development	IMP IMP: Inferred from mutant phenotype	23676498	MGI
acts upstream of or within mesoderm formation	IMP IMP: Inferred from mutant phenotype	10772805	MGI
involved in mitral valve morphogenesis	IMP IMP: Inferred from mutant phenotype	19409885	MGI
involved in negative regulation of cell proliferation involved in heart valve morphogenesis	IMP IMP: Inferred from mutant phenotype	19409885	MGI
involved in negative regulation of muscle cell differentiation	IDA IDA: Inferred from direct assay	21976273	MGI
involved in negative regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	18552156	MGI
involved in osteoblast differentiation	IDA IDA: Inferred from direct assay	7798324	MGI
involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	19409885	MGI
NOT involved in outflow tract septum morphogenesis	IMP IMP: Inferred from mutant phenotype	19409885	MGI
involved in outflow tract septum morphogenesis	IMP IMP: Inferred from mutant phenotype	12441304	MGI
NOT involved in pharyngeal arch artery morphogenesis	IMP IMP: Inferred from mutant phenotype	19409885	MGI
involved in pharyngeal arch artery morphogenesis	IMP IMP: Inferred from mutant phenotype	12441304	MGI
involved in positive regulation of axon extension involved in axon guidance	IMP IMP: Inferred from mutant phenotype	24052814	MGI
involved in positive regulation of ossification	IMP IMP: Inferred from mutant phenotype	12441304	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12441304	MGI
involved in pulmonary valve development	IMP IMP: Inferred from mutant phenotype	12441304	MGI
involved in regulation of lung blood pressure	IMP IMP: Inferred from mutant phenotype	18552156	MGI
involved in retina vasculature development in camera-type eye	IMP IMP: Inferred from mutant phenotype	19903896	MGI
involved in semi-lunar valve development	IMP IMP: Inferred from mutant phenotype	12441304	MGI
involved in tricuspid valve morphogenesis	IMP IMP: Inferred from mutant phenotype	19409885	MGI
involved in venous blood vessel development	IMP IMP: Inferred from mutant phenotype	19903896	MGI
involved in ventricular septum morphogenesis	IMP IMP: Inferred from mutant phenotype	12441304	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in axon	IDA IDA: Inferred from direct assay	17634368	MGI
is active in cell body	IDA IDA: Inferred from direct assay	17634368	MGI
located in cell surface	IDA IDA: Inferred from direct assay	12117821	MGI
is active in clathrin-coated pit	IDA IDA: Inferred from direct assay	16923969	MGI
is active in dendrite	IDA IDA: Inferred from direct assay	17634368	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	21976273	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	23676498	MGI
is active in plasma membrane region	IDA IDA: Inferred from direct assay	16923969	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	17114649	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bmpr2 Protein Structure

Activin_recp

STKc_BMPR2_AMHR2

0
200
400
600
800
1038 a.a.

Protein Preferred Names

Protein Names

bone morphogenetic protein receptor type-2

BMP type II receptor	BMP type-2 receptor
bone morphogenic protein receptor, type II (serine/threonine kinase)

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15897	LDN-212854	Inhibitor	99.70%	Unkown
HY-154970A	BMPR2-IN-1 TFA	Inhibitor	99.40%	Unkown
HY-154970	BMPR2-IN-1	Inhibitor	/	Unkown
HY-164145	CDD-1653		/	Unkown
HY-RS01552	BMPR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01553	Bmpr2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01554	Bmpr2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bmpr2	NCBI	NCBI:659

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