2. Gene
  3. PSMB11 - proteasome subunit beta 11 Gene

PSMB11 - proteasome subunit beta 11 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as BETA5T

Gene ID: 122706 | Gene type: protein coding

About PSMB11

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:23,042,212-23,044,060 (from NCBI)

This gene has 1 transcript (splice variant), 228 orthologues and 18 paralogues.

Summary

Proteasomes generate Peptides that are presented by major histocompatibility complex (MHC) I molecules to Other cells of the immune system. Proteolysis is conducted by 20S proteasomes, complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7, and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM 600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM 600306). Three additional subunits, beta-1i (PSMB9; MIM 177045), beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), are induced by gamma-interferon (IFNG; MIM 147570) and are preferentially incorporated into proteasomes to make immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit expressed exclusively in cortical thymic epithelial cells (Murata et al., 2007 [PubMed 17540904]).[supplied by OMIM, Mar 2008]

PSMB11 Products(1)

mRNA Protein Name
NM_001099780.2 NP_001093250.1 proteasome subunit beta type-11
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables peptidase activity IDA
IDA: Inferred from direct assay
17540904 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within proteolysis IDA
IDA: Inferred from direct assay
17540904 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMB11 Protein Structure

Proteasome

Proteasome: Proteasome subunit (47 - 226)

  • 0
  • 100
  • 200
  • 300 a.a.
Protein Preferred Names Protein Names

proteasome subunit beta type-11

proteasome (prosome, macropain) subunit, beta type, 11

PSMB11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PSMB11 A5LHX3 ATG5 Homo sapiens Q9H1Y0
Validated Y2H
32296183
Intra
PSMB11 A5LHX3 TLX3 Homo sapiens O43711
Validated Y2H
32296183
Intra
PSMB11 A5LHX3 HGS Homo sapiens O14964
Validated Y2H
32296183
Intra
PSMB11 A5LHX3 PITX1 Homo sapiens P78337
Validated Y2H
32296183
Intra
PSMB11 A5LHX3 PROP1 Homo sapiens O75360
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Encapsulated Thymoma
Thymic Dysplasia
Disseminated Chorioretinitis
Thymoma

Primary Thymic Epithelial Neoplasm

Primary Thymic Epithelial Tumor

Thymus Neoplasms
Predominantly Cortical Thymoma

Lymphocyte-Predominant Thymoma

Thymoma, Organoid

Thymoma, Type B1
T-Cell Immunodeficiency With Thymic Aplasia

Nezelof Syndrome

T-Lymphocyte Deficiency

TIDTA

Immune Defect Due To Absence Of Thymus

Thymic Aplasia

Nezelof'S Syndrome

Thymic Dysplasia With Normal Immunoglobulins

Thymic Aplasia Syndrome

T-Lymphocyte Immunodeficiency
Thymic Carcinoma

Malignant Thymoma

Thymoma, Malignant
Thymus Gland Disease

Disease Of Thymus Gland
Thymus Cancer

Thymic Neoplasm

Thymic Tumor

Thymus Neoplasm

Thymus Neoplasms

Malignant Neoplasm Of Thymus

Neoplasm Of Thymus

Thymic Neoplasms

Thymoma, Familial

Thymic Carcinoma

Thymoma, Type C

Cancer Of Thymus

Malignant Tumour Of Thymus

Primary Malignant Neoplasm Of Thymus

Thymic Glandular Cancer

Thymus Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11301 PSMB11 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PSMB11 MGD MGI:1921152
Felis catus PSMB11 VGNC VGNC:64413
Rattus norvegicus PSMB11 RGD RGD:1308773
Canis familiaris PSMB11 VGNC VGNC:45094
Bos taurus PSMB11 VGNC VGNC:33445