PROP1 - PROP paired-like homeobox 1 Gene

Homo sapiens

Also known as CPHD2; PROP-1

Gene ID: 5626 | Gene type: protein coding

About PROP1

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:177,992,235-177,996,242 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 109 orthologues, 50 paralogues and is associated with 5 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, Prolactin, and thyroid-stimulating hormone. [provided by RefSeq, Sep 2011]

PROP1 Products(1)

mRNA	Protein	Name
NM_006261.5	NP_006252.4	homeobox protein prophet of Pit-1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23732115	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PROP1 Protein Structure

Homeobox

0
100
200
226 a.a.

Protein Preferred Names

Protein Names

homeobox protein prophet of Pit-1

pituitary-specific homeodomain factor

PROP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PROP1	O75360	METTL15	Homo sapiens	A6NJ78-4	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	METTL15	Homo sapiens	A6NJ78-4	Y2H Array	32296183
Intra	PROP1	O75360	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
Intra	PROP1	O75360	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	PROP1	O75360	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	P4HA3	Homo sapiens	Q7Z4N8	Y2H Array	32296183
Intra	PROP1	O75360	P4HA3	Homo sapiens	Q7Z4N8	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	P4HA3	Homo sapiens	Q7Z4N8	Validated Y2H	32296183
Intra	PROP1	O75360	OLIG3	Homo sapiens	Q7RTU3	Validated Y2H	32296183
Intra	PROP1	O75360	TEKT5	Homo sapiens	Q96M29	Validated Y2H	32296183
Intra	PROP1	O75360	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	KRTAP19-7	Homo sapiens	Q3SYF9	Validated Y2H	32296183
Intra	PROP1	O75360	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Array	32296183
Intra	PROP1	O75360	NR1D2	Homo sapiens	Q6NSM0	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	NR1D2	Homo sapiens	Q6NSM0	Validated Y2H	32296183
Intra	PROP1	O75360	NR1D2	Homo sapiens	Q6NSM0	Y2H Array	32296183
Intra	PROP1	O75360	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	KRTAP8-1	Homo sapiens	Q8IUC2	Validated Y2H	32296183
Intra	PROP1	O75360	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Array	32296183
Intra	PROP1	O75360	SPMIP6	Homo sapiens	Q8NCR6	Y2H Array	32296183
Intra	PROP1	O75360	SPMIP6	Homo sapiens	Q8NCR6	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	SPMIP6	Homo sapiens	Q8NCR6	Validated Y2H	32296183
Intra	PROP1	O75360	COX6B2	Homo sapiens	Q6YFQ2	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	COX6B2	Homo sapiens	Q6YFQ2	Validated Y2H	32296183
Intra	PROP1	O75360	COX6B2	Homo sapiens	Q6YFQ2	Y2H Array	32296183
Intra	PROP1	O75360	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	PROP1	O75360	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	PROP1	O75360	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Array	32296183
Intra	PROP1	O75360	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	ACTMAP	Homo sapiens	Q5BKX5-3	Validated Y2H	32296183
Intra	PROP1	O75360	FAM168A	Homo sapiens	Q92567-2	Validated Y2H	32296183
Intra	PROP1	O75360	FAM168A	Homo sapiens	Q92567-2	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	FAM168A	Homo sapiens	Q92567-2	Y2H Array	32296183
Intra	PROP1	O75360	C6orf15	Homo sapiens	Q6UXA7	Validated Y2H	32296183
Intra	PROP1	O75360	C6orf15	Homo sapiens	Q6UXA7	Y2H Array	32296183
Intra	PROP1	O75360	C6orf15	Homo sapiens	Q6UXA7	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	POU6F2	Homo sapiens	P78424	Validated Y2H	32296183
Intra	PROP1	O75360	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
Intra	PROP1	O75360	POU6F2	Homo sapiens	P78424	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	TMEM42	Homo sapiens	Q69YG0	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	TMEM42	Homo sapiens	Q69YG0	Validated Y2H	32296183
Intra	PROP1	O75360	TMEM42	Homo sapiens	Q69YG0	Y2H Array	32296183
Intra	PROP1	O75360	UFSP1	Homo sapiens	Q6NVU6	Validated Y2H	32296183
Intra	PROP1	O75360	UFSP1	Homo sapiens	Q6NVU6	Y2H Array	32296183
Intra	PROP1	O75360	UFSP1	Homo sapiens	Q6NVU6	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	SMUG1	Homo sapiens	Q53HV7-2	Validated Y2H	32296183
Intra	PROP1	O75360	SMUG1	Homo sapiens	Q53HV7-2	Y2H Array	32296183
Intra	PROP1	O75360	SMUG1	Homo sapiens	Q53HV7-2	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	ABHD11	Homo sapiens	Q8NFV4-4	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	ABHD11	Homo sapiens	Q8NFV4-4	Y2H Array	32296183
Intra	PROP1	O75360	ABHD11	Homo sapiens	Q8NFV4-4	Validated Y2H	32296183
Intra	PROP1	O75360	KRTAP19-6	Homo sapiens	Q3LI70	Y2H Array	32296183
Intra	PROP1	O75360	KRTAP19-6	Homo sapiens	Q3LI70	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	KRTAP19-6	Homo sapiens	Q3LI70	Validated Y2H	32296183
Intra	PROP1	O75360	CIMIP2A	Homo sapiens	Q6J272	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	CIMIP2A	Homo sapiens	Q6J272	Validated Y2H	32296183
Intra	PROP1	O75360	CIMIP2A	Homo sapiens	Q6J272	Y2H Array	32296183
Intra	PROP1	O75360	KRTAP19-1	Homo sapiens	Q8IUB9	Y2H Array	32296183
Intra	PROP1	O75360	KRTAP19-1	Homo sapiens	Q8IUB9	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	KRTAP19-1	Homo sapiens	Q8IUB9	Validated Y2H	32296183
Intra	PROP1	O75360	OXER1	Homo sapiens	Q8TDS5	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	OXER1	Homo sapiens	Q8TDS5	Validated Y2H	32296183
Intra	PROP1	O75360	OXER1	Homo sapiens	Q8TDS5	Y2H Array	32296183
Intra	PROP1	O75360	PSMB11	Homo sapiens	A5LHX3	Y2H Array	32296183
Intra	PROP1	O75360	PSMB11	Homo sapiens	A5LHX3	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	ARSA	Homo sapiens	P15289	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	ARSA	Homo sapiens	P15289	Validated Y2H	32296183
Intra	PROP1	O75360	ARSA	Homo sapiens	P15289	Y2H Array	32296183
Intra	PROP1	O75360	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
Intra	PROP1	O75360	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	RNF4	Homo sapiens	P78317	Validated Y2H	32296183
Intra	PROP1	O75360	RNF4	Homo sapiens	P78317	Y2H Array	32296183
Intra	PROP1	O75360	HNRNPF	Homo sapiens	P52597	Validated Y2H	32296183
Intra	PROP1	O75360	PLEKHB2	Homo sapiens	Q96CS7	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	PLEKHB2	Homo sapiens	Q96CS7	Validated Y2H	32296183
Intra	PROP1	O75360	PLEKHB2	Homo sapiens	Q96CS7	Y2H Array	32296183
Intra	PROP1	O75360	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	PROP1	O75360	TRIM42	Homo sapiens	Q8IWZ5	Validated Y2H	32296183
Intra	PROP1	O75360	TRIM42	Homo sapiens	Q8IWZ5	Y2H Array	32296183
Intra	PROP1	O75360	TRIM42	Homo sapiens	Q8IWZ5	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	PSMB4	Homo sapiens	P28070	Validated Y2H	32296183
Intra	PROP1	O75360	PSMB4	Homo sapiens	P28070	Y2H Array	32296183
Intra	PROP1	O75360	PSMB4	Homo sapiens	P28070	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	TBX22	Homo sapiens	Q9Y458	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	TBX22	Homo sapiens	Q9Y458	Validated Y2H	32296183
Intra	PROP1	O75360	TBX22	Homo sapiens	Q9Y458	Y2H Array	32296183
Intra	PROP1	O75360	CRYBA1	Homo sapiens	P05813	Validated Y2H	32296183
Intra	PROP1	O75360	CRYBA1	Homo sapiens	P05813	Y2H Array	32296183
Intra	PROP1	O75360	CRYBA1	Homo sapiens	P05813	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	TINAGL1	Homo sapiens	Q9GZM7	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	TINAGL1	Homo sapiens	Q9GZM7	Validated Y2H	32296183
Intra	PROP1	O75360	TINAGL1	Homo sapiens	Q9GZM7	Y2H Array	32296183
Intra	PROP1	O75360	MAGED1	Homo sapiens	Q9Y5V3	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	MAGED1	Homo sapiens	Q9Y5V3	Validated Y2H	32296183
Intra	PROP1	O75360	MAGED1	Homo sapiens	Q9Y5V3	Y2H Array	32296183
Intra	PROP1	O75360	TLE5	Homo sapiens	Q08117	Y2H	23732115
Intra	PROP1	O75360	CFAP68	Homo sapiens	Q9H5F2	Validated Y2H	32296183
Intra	PROP1	O75360	CFAP68	Homo sapiens	Q9H5F2	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	CFAP68	Homo sapiens	Q9H5F2	Y2H Array	32296183
Intra	PROP1	O75360	DAZAP2	Homo sapiens	Q15038	Validated Y2H	32296183
Intra	PROP1	O75360	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	PROP1	O75360	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	HOXA1	Homo sapiens	P49639	Validated Y2H	32296183
Intra	PROP1	O75360	BATF2	Homo sapiens	Q8N1L9	Validated Y2H	32296183
Intra	PROP1	O75360	BATF2	Homo sapiens	Q8N1L9	Y2H Array	32296183
Intra	PROP1	O75360	BATF2	Homo sapiens	Q8N1L9	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	EFEMP2	Homo sapiens	O95967	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	EFEMP2	Homo sapiens	O95967	Y2H Array	32296183
Intra	PROP1	O75360	EFEMP2	Homo sapiens	O95967	Validated Y2H	32296183
Intra	PROP1	O75360	HDHD3	Homo sapiens	Q9BSH5	Validated Y2H	32296183
Intra	PROP1	O75360	HDHD3	Homo sapiens	Q9BSH5	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	HDHD3	Homo sapiens	Q9BSH5	Y2H Array	32296183
Intra	PROP1	O75360	INTS11	Homo sapiens	Q5TA45	Validated Y2H	32296183
Intra	PROP1	O75360	INTS11	Homo sapiens	Q5TA45	Y2H Array	32296183
Intra	PROP1	O75360	INTS11	Homo sapiens	Q5TA45	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	TEKT4	Homo sapiens	Q8WW24	Validated Y2H	32296183
Intra	PROP1	O75360	TENT5B	Homo sapiens	Q96A09	Validated Y2H	32296183
Intra	PROP1	O75360	SUMO1	Homo sapiens	P63165	Y2H Array	32296183
Intra	PROP1	O75360	SUMO1	Homo sapiens	P63165	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	SUMO1	Homo sapiens	P63165	Validated Y2H	32296183
Intra	PROP1	O75360	METTL27	Homo sapiens	Q8N6F8	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	METTL27	Homo sapiens	Q8N6F8	Validated Y2H	32296183
Intra	PROP1	O75360	METTL27	Homo sapiens	Q8N6F8	Y2H Array	32296183
Intra	PROP1	O75360	ZNF503	Homo sapiens	Q96F45	Validated Y2H	32296183
Intra	PROP1	O75360	ZNF503	Homo sapiens	Q96F45	Y2H Array	32296183
Intra	PROP1	O75360	ZNF503	Homo sapiens	Q96F45	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	C1orf94	Homo sapiens	Q6P1W5	Y2H Prey Pooling	32296183
Intra	PROP1	O75360	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	32296183
Intra	PROP1	O75360	C1orf94	Homo sapiens	Q6P1W5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pituitary Hormone Deficiency, Combined, 2

Panhypopituitarism	Combined Pituitary Hormone Deficiency
CPHD2	Ateliotic Dwarfism With Hypogonadism
Pituitary Dwarfism Iii	Hanhart Dwarfism
Simmond'S Disease	Simmonds' Disease
Cphd	Pituitary Hormone Deficiency, Combined
Hormone Deficiency, Pituitary, Combined, Type 2	Pituitary Dwarfism Type 3
Sheehan Syndrome

Combined Pituitary Hormone Deficiencies, Genetic Forms

Congenital Hypopituitarism	Pituitary Hormone Deficiency, Combined 1
Congenital Combined Pituitary Hormone Deficiency	Non-Acquired Combined Pituitary Hormone Deficiency
Cphd1	Familial Congenital Hypopituitarism
Multiple Pituitary Hormone Deficiencies, Genetic Forms	Combined Pituitary Hormone Deficiencies, Genetic Form
Hormone Deficiency, Pituitary, Combined, Type 1

Non-Acquired Panhypopituitarism

Genetic Panhypopituitarism

46,Xy Partial Gonadal Dysgenesis

46,Xy Pgd

46,Xy Partial Testicular Dysgenesis

Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function

Hypopituitarism

Pituitary Hypofunction	Pituitary Insufficiency
Pituitary Hormone Deficiency	Subpituitarism
Hypophyseal Dystrophy	Hypohypophysism
Anterior Pituitary Insufficiency	Deficient Secretion Of One Or More Pituitary Hormones
Hypopituitarism Syndrome	Pituitary Deficiency
Pituitary Failure	Pituitary Insufficiency Nos
Anterior Pituitary Hypofunction	Deficient Secretion Of All Pituitary Hormones
Hypopituitary Dwarfism	Hyposomatotropic Dwarfism
Hypophyseal Dwarfism	Hypopituitary Cachexia
Hypophyseal Short Stature	Panhypopituitarism Syndrome
Pituitary Cachexia	Juvenile Hypopituitarism
Pituitary Dwarfism	Pituitary Gland Hypofunction
Primary Hypopituitarism	Secondary Hypogonadism
Prepubertal Panhypopituitarism	Prepubertal Dwarfism
Postpartum Panhypopituitary Syndrome	Postpartum Hypopituitarism
Pituitary Short Stature	Pituitary Infantilism
Pituitary Hypogonadism	Pituitary Hypoadrenocorticism

Pituitary Tumors

Pituitary Tumor

Pituitary Neoplasms

Hypothyroidism, Congenital, Nongoitrous, 4

Tsh Deficiency	CHNG4
Thyrotropin Deficiency, Isolated	Pituitary Cretinism
Congenital Nongoitrous Hypothyroidism 4	Isolated Thyrotropin Deficiency
Thyroid-Stimulating Hormone Deficiency	Hypothyroidism, Congenital, Nongoitrous 4
Thyroid-Stimulating Hormone, Deficiency Of	Isolated Thyroid-Stimulating Hormone Deficiency
Isolated Tsh Deficiency	Hypothyroidism, Congenital, Nongoitrous, Type 4
Secondary Hypothyroidism	Tsh - [Thyroid Stimulating Hormone] Deficiency

Hypogonadism

Pituitary Gland Disease

Pituitary Diseases	Pituitary Dysfunction
Pituitary Disease	Pituitary Deficiency
Pituitary Disorders

Septooptic Dysplasia

Septo-Optic Dysplasia	De Morsier Syndrome
Growth Hormone Deficiency With Pituitary Anomalies	SOD
Pituitary Hormone Deficiency, Combined, 5	Septo-Optic Dysplasia Spectrum
Septo-Optic Dysplasia With Growth Hormone Deficiency	Pituitary Hormone Deficiency, Combined 5
Hypopituitarism And Septooptic 'Dysplasia'	GHDPA
CPHD5	Dysplasia, Septo-Optic
Kallmann Syndrome

Hypogonadotropic Hypogonadism

Klinefelter Syndrome	Klinefelter'S Syndrome
Xxy Syndrome	Xxy Trisomy
Hypogonadotropism	47, Xxy
Congenital Idiopathic Hypogonadotropic Hypogonadism	Isolated Congenital Gonadotropin Deficiency
47,Xxy Syndrome	47, Xxy Syndrome
Klinefelters Syndrome	Hypogonadism
Klinefelter Syndrome In Males	Klinefelter Syndrome, Unspecified
Klinefelter Syndrome Karyotype 47, Xxy

Empty Sella Syndrome

Empty Sella Turcica

Empty Sella

Hypothyroidism

Thyroid Diseases	Thyroid Disease
Thyroid Deficiency	Thyroid Insufficiency
Dysfunction Thyroid	Thyroid Dysfunction

Craniopharyngioma

Neoplasm Of Rathke'S Pouch	Adamantinomatous Tumor
Craniopharyngeal Duct Tumor	Dysodontogenic Epithelial Tumor
Rathke'S Pouch Tumor

Sheehan Syndrome

Postpartum Hypopituitarism	Sheehan'S Syndrome
Postpartum Panhypopituitarism	Postpartum Panhypopituitary Syndrome
Postpartum Pituitary Necrosis	Simmond'S Disease

Kallmann Syndrome

Hypogonadism With Anosmia	Kallman'S Syndrome
Anosmic Hypogonadism	Anosmic Idiopathic Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism And Anosmia	Hypogonadotropic Hypogonadism-Anosmia Syndrome
Olfacto-Genital Pathological Sequence	Familial Hypogonadism With Anosmia
Kallman Syndrome	Dysplasia Olfactogenitalis Of De Morsier
Kallmann'S Syndrome	Congenital Hypogonadotropic Hypogonadism With Anosmia

Pituitary Hypoplasia

Hypoplasia Of The Pituitary Gland

Tungiasis

Tunga Penetrans Infestation	Chigger Flea
S Penetrans	Sarcopsylla Penetrans
T Penetrans	Tunga Penetrans
Sand-Flea Infestation	Jiggers Infestation
Chigoe Infestation	Jigger Disease

Complement Component 2 Deficiency

C2D	C2 Deficiency
Complement 2 Deficiency	Complement Component-2

Isolated Growth Hormone Deficiency, Type Ia

Ighd Ia	Primordial Dwarfism
Isolated Growth Hormone Deficiency Type Ia	Sexual Ateleiotic Dwarfism
Pituitary Dwarfism I	IGHD1A
Illig-Type Growth Hormone Deficiency	Growth Hormone Deficiency, Isolated, Type Ia
Congenital Ighd Type Ia	Congenital Isolated Gh Deficiency Type Ia
Congenital Isolated Growth Hormone Deficiency Type Ia	Pituitary Dwarfism 1
Growth Hormone Deficiency, Isolated, Autosomal Recessive	Autosomal Recessive Isolated Growth Hormone Deficiency
Isolated Growth Hormone Deficiency Type 1a	Congenital Ighd
Congenital Isolated Gh Deficiency	Congenital Isolated Growth Hormone Deficiency
Growth Hormone Deficiency, Isolated Autosomal Recessive	Illig Type Growth Hormone Deficiency
Non-Acquired Isolated Growth Hormone Deficiency	Growth Hormone Deficiency, Isolated, 1a
Growth Hormone Deficiency Isolated Autosomal Recessive	Dwarfism, Primordial
Dwarfism

Seckel Syndrome 5

SCKL5

Seckel Syndrome, Type 5

Microcephaly 1, Primary, Autosomal Recessive

MCPH1	Premature Chromosome Condensation Syndrome
Pcc Syndrome	Primary Autosomal Recessive Microcephaly 1
Microcephaly, Primary Autosomal Recessive, 1	Premature Chromosome Condensation With Microcephaly And Mental Retardation
Microcephaly Vera	True Microcephaly
Microcephaly, Type 1, Primary, Autosomal Recessive	Autosomal Recessive Primary Microcephaly

Acth Deficiency, Isolated

Adrenocorticotropic Hormone Deficiency	IAD
Congenital Isolated Acth Deficiency	Isolated Acth Deficiency
Isolated Adrenocorticotropic Hormone Deficiency	Adrenocorticotropic Hormone Deficiency
Adrenocorticotropic Hormone [Acth] Deficiency	Secondary Adrenocortical Insufficiency

Isolated Growth Hormone Deficiency, Type Ii

Ighd Ii	Isolated Growth Hormone Deficiency Type Ii
IGHD2	Growth Hormone Deficiency, Isolated, Type Ii
Congenital Ighd Type Ii	Congenital Isolated Gh Deficiency Type Ii
Congenital Isolated Growth Hormone Deficiency Type Ii	Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency Autosomal Dominant
Growth Hormone Deficiency, Isolated, Autosomal Dominant	Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency, Autosomal Dominant
Autosomal Dominant Isolated Growth Hormone Deficiency	Autosomal Dominant Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency
Isolated Growth Hormone Deficiency Type 2	Growth Hormone Deficiency, Isolated Autosomal Dominant
Growth Hormone Deficiency, Isolated, 2	Growth Hormone Deficiency Isolated Autosomal Dominant

Hypothyroidism, Central, With Testicular Enlargement

X-Linked Central Congenital Hypothyroidism With Late-Onset Testicular Enlargement	CHTE
Hypothyroidism, Central, And Testicular Enlargement	Igsf1 Deficiency Syndrome
X-Linked Central Congenital Hypothyroidism With Late-Onset Macroorchidism	Central Hypothyroidism And Testicular Enlargement
Hypothyroidism, Central, Testicular Enlargement

Isolated Growth Hormone Deficiency

Congenital Ighd	Congenital Isolated Gh Deficiency
Congenital Isolated Growth Hormone Deficiency	Non-Acquired Isolated Growth Hormone Deficiency
Pituitary Dwarfism	Dwarfism, Pituitary
Isolated Somatotropin Deficiency	Isolated Congenital Growth Hormone Deficiency
Familial Isolated Growth Hormone Deficiency	Ighd
Dwarfism, Growth Hormone Deficiency	Growth Hormone Deficiency Dwarfism
Isolated Gh Deficiency	Isolated Hgh Deficiency
Isolated Human Growth Hormone Deficiency	Isolated Somatotropin Deficiency Disorder
Dwarfism Pituitary

Situs Inversus

Situs Inversus Viscerum	Laterality Sequence
Complete Transposition	Siv

Adamantinous Craniopharyngioma

Adamantinous Rathke'S Pouch Tumor	Craniopharyngioma, Adamantinomatous
Adamantinomatous Craniopharyngioma

Congenital Hypothyroidism

Cretinism	Neonatal Hypothyroidism
Ch	Cht
Congenital Myxedema	Myxedema, Congenital
Endemic Cretinism	Congenital Iodine-Deficiency Syndrome
Fetal Iodine Deficiency Syndrome	Congenital Iodine-Deficiency Hypothyroidism Nos

Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism	Undescended Testicle
Undescended Testis	Cryptorchism
Undescended Testicles	CRYPTO
Impaired Testicular Descent	Cryptosporidiosis
Retained Testis	Unilateral Cryptorchidism
Unilateral Undescended Testis	Nondescent Unilateral Testicle
Unilateral Cryptorchism	Ectopic Testis, Unilateral
Bilateral Cryptorchidism	Bilateral Cryptorchism
Bilateral Nondescent Testicle	Bilateral Undescended Testes
Bilateral Ectopic Testes

Holoprosencephaly

Holoprosencephaly Sequence	Hpe
Hpe - [Holoprosencephaly]

46,Xy Sex Reversal

Swyer Syndrome	Pure Gonadal Dysgenesis 46,Xy
Gonadal Dysgenesis, Xy Female Type	Gonadal Dysgenesis, 46,Xy
46,Xy Cgd	46,Xy Complete Gonadal Dysgenesis
46,Xy Pure Gonadal Dysgenesis	46 Xy Gonadal Dysgenesis
46, Xy Cgd	46, Xy Complete Gonadal Dysgenesis
46, Xy Pure Gonadal Dysgenesis	Xy Pure Gonadal Dysgenesis
Female With 46,Xy Karyotype	Xy Females

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11200	PROP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PROP1	RGD	RGD:628759
Mus musculus	PROP1	MGD	MGI:109330
Macaca mulatta	PROP1	VGNC	VGNC:110442
Canis familiaris	PROP1	VGNC	VGNC:45014
Bos taurus	PROP1	VGNC	VGNC:33366