LRR1 - leucine rich repeat protein 1 Gene

Homo sapiens

Also known as LRR-1; PPIL5; 4-1BBLRR

Gene ID: 122769 | Gene type: protein coding

About LRR1

Cytogenetic location: 14q21.3 Genomic coordinates (GRCh38): 14:49,598,940-49,614,672 (from NCBI)

This gene has 5 transcripts (splice variants) and 184 orthologues. Broad expression in testis (RPKM 19.8), bone marrow (RPKM 6.1) and 21 other tissues.

Summary

The protein encoded by this gene contains a leucine-rich repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2), which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

LRR1 Products(2)

mRNA	Protein	Name
NM_152329.4	NP_689542.2	leucine-rich repeat protein 1 isoform 1
NM_203467.2	NP_982292.1	leucine-rich repeat protein 1 isoform 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRR1 Protein Structure

LRR_4

LRR_1

0
100
200
300
414 a.a.

Protein Preferred Names

Protein Names

leucine-rich repeat protein 1

4-1BB-mediated signaling molecule

LRR1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LRR1	Q96L50	PNMA2	Homo sapiens	Q9UL42	Y2H Prey Pooling	25416956
Intra	LRR1	Q96L50	TRIP13	Homo sapiens	Q15645	Validated Y2H	25416956
Intra	LRR1	Q96L50	MTUS2	Homo sapiens	Q5JR59	Y2H Array	25416956
Intra	LRR1	Q96L50	MTUS2	Homo sapiens	Q5JR59	Validated Y2H	25416956
Intra	LRR1	Q96L50	PFKFB4	Homo sapiens	Q16877	Y2H Array	32296183
Intra	LRR1	Q96L50	PFKFB4	Homo sapiens	Q16877	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Anal Canal Squamous Cell Carcinoma

Squamous Cell Carcinoma Of The Anal Canal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07805	LRR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LRR1	MGD	MGI:1916956
Bos taurus	LRR1	VGNC	VGNC:30997
Macaca mulatta	LRR1	VGNC	VGNC:99202
Rattus norvegicus	LRR1	RGD	RGD:1589026
Canis familiaris	LRR1	VGNC	VGNC:42782
Felis catus	LRR1	VGNC	VGNC:104485
Others	LRR1	NCBI

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