2. Gene
  3. PFKFB4 - 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 Gene

PFKFB4 - 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 5210 | Gene type: protein coding

About PFKFB4

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,517,684-48,563,136 (from NCBI)

This gene has 15 transcripts (splice variants), 278 orthologues and 3 paralogues. Broad expression in testis (RPKM 10.5), small intestine (RPKM 8.0) and 18 other tissues.

Summary

The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in Cancer cells and is induced by hypoxia. This protein is essential to the survival of Cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in Cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

PFKFB4 Products(6)

mRNA Protein Name
NM_001317134.2 NP_001304063.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 isoform a
NM_001317135.2 NP_001304064.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 isoform c
NM_001317136.2 NP_001304065.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 isoform d
NM_001317137.2 NP_001304066.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 isoform e
NM_001317138.2 NP_001304067.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 isoform f
NM_004567.4 NP_004558.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 isoform b
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PFKFB4 Protein Structure

6PF2K

6PF2K: 6-phosphofructo-2-kinase (35 - 249)

His_Phos_1

His_Phos_1: Histidine phosphatase superfamily (branch 1) (252 - 398)

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  • 469 a.a.
Protein Preferred Names Protein Names

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4

6PF-2-K/Fru-2,6-P2ase 4

PFKFB4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra PFKFB4 Q16877 CCDC102B Homo sapiens Q68D86
Validated Y2H
32296183
Intra PFKFB4 Q16877 LRR1 Homo sapiens Q96L50
Validated Y2H
32296183
Intra PFKFB4 Q16877 CDC23 Homo sapiens Q9UJX2
Validated Y2H
32296183
Intra PFKFB4 Q16877 PFKFB1 Homo sapiens P16118
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-123981 5MPN 99.72% Unkown
HY-RS10364 PFKFB4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PFKFB4 VGNC VGNC:44445
Mus musculus PFKFB4 MGD MGI:2687284
Bos taurus PFKFB4 VGNC VGNC:32772
Macaca mulatta PFKFB4 VGNC VGNC:75960
Rattus norvegicus PFKFB4 RGD RGD:3310
Felis catus PFKFB4 VGNC VGNC:68806