Calca - calcitonin/calcitonin-related polypeptide, alpha Gene

Mus musculus

Also known as CA; Ct; Ctn; Calc; Cgrp; CGRP1; Calc1; CGRP-1

Gene ID: 12310 | Gene type: protein coding

About Calca

Summary

This gene encodes the peptide hormones Calcitonin, Calcitonin gene-related peptide (CGRP) and katacalcin. Alternative splicing of the mRNA results in multiple variants that encode either Calcitonin or CGRP preproproteins. Post-translational processing of the Calcitonin and CGRP propeptides results in either Calcitonin and katacalcin, or CGRP, respectively. Calcitonin and katacalcin modulate calcium levels in the blood stream. CGRP can function as a vasodilator and play a role in the transmission of pain. The human homolog of CGRP was found to have antimicrobial activity. [provided by RefSeq, Mar 2015]

Calca Products(4)

mRNA	Protein	Name
NM_001033954.3	NP_001029126.1	calcitonin gene-related peptide 1 isoform Cgrp preproprotein
NM_001289444.1	NP_001276373.1	calcitonin gene-related peptide 1 isoform Cgrp preproprotein
NM_001305616.1	NP_001292545.1	calcitonin gene-related peptide 1 isoform Calca preproprotein
NM_007587.2	NP_031613.2	calcitonin gene-related peptide 1 isoform Calca preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcitonin receptor binding	IDA IDA: Inferred from direct assay	9322931	MGI
enables signaling receptor binding	IDA IDA: Inferred from direct assay	7698182	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within activation of adenylate cyclase activity	IDA IDA: Inferred from direct assay	8582325	MGI
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IGI IGI: Inferred from genetic interaction	8582325	MGI
acts upstream of or within artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure	IMP IMP: Inferred from mutant phenotype	11717154	MGI
acts upstream of or within cellular response to nerve growth factor stimulus	IDA IDA: Inferred from direct assay	24760869	MGI
acts upstream of or within detection of temperature stimulus involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	16118273	MGI
acts upstream of or within feeding behavior	IDA IDA: Inferred from direct assay	8735980	MGI
acts upstream of or within inflammatory response	IDA IDA: Inferred from direct assay	7698182	MGI
acts upstream of or within intracellular calcium ion homeostasis	IGI IGI: Inferred from genetic interaction	12488435	MGI
acts upstream of or within negative regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	10642343	MGI
acts upstream of or within negative regulation of ossification	IMP IMP: Inferred from mutant phenotype	12488435	MGI
acts upstream of or within negative regulation of smooth muscle contraction	IDA IDA: Inferred from direct assay	9322931	MGI
acts upstream of or within neuropeptide signaling pathway	IDA IDA: Inferred from direct assay	7698182	MGI
acts upstream of ossification	IMP IMP: Inferred from mutant phenotype	12488435	MGI
acts upstream of or within response to heat	IMP IMP: Inferred from mutant phenotype	11166483	MGI
acts upstream of or within response to pain	IMP IMP: Inferred from mutant phenotype	10208559	MGI
acts upstream of smooth muscle contraction	IDA IDA: Inferred from direct assay	9322931	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	7521790	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	9271704	MGI
located in extracellular region	IDA IDA: Inferred from direct assay	8735980	MGI
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	7955356	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	11466438	MGI
located in terminal bouton	IDA IDA: Inferred from direct assay	8453761	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

calcitonin gene-related peptide 1

alpha-type CGRP

calcitonin gene-related peptide I

Recombinant Calca Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77587	Calcitonin/CALCA Protein, Mouse (HEK293, Fc)	Q99JA0 (V26-F119)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01828	CALCA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Calca	NCBI	NCBI:796

Name
Email *

	Sorry, but the email address you supplied was invalid.