Car2 - carbonic anhydrase 2 Gene

Mus musculus

Also known as Ca2; CAII; Car-2; Ltw-5; Lvtw-5

Gene ID: 12349 | Gene type: protein coding

About Car2

Chromosome 3: 14,951,333-14,965,830 forward strand.GRCm39:CM000996.3

This gene has 3 transcripts (splice variants), 285 orthologues, 15 paralogues and is associated with 19 phenotypes. Biased expression in liver E14 (RPKM 556.3), liver E14.5 (RPKM 538.2) and 14 other tissues.

Summary

Enables carbonate dehydratase activity. Involved in positive regulation of dipeptide transmembrane transport and regulation of intracellular pH. Acts upstream of or within several processes, including carbon dioxide transport; positive regulation of GABAergic synaptic transmission; and positive regulation of cellular pH reduction. Located in cytosol and myelin sheath. Is expressed in several structures, including alimentary system; brain; heart; metanephros; and sensory organ. Used to study autosomal recessive osteopetrosis 3. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 3 and osteopetrosis. Orthologous to human CA2 (Carbonic Anhydrase 2). [provided by Alliance of Genome Resources, Apr 2022]

Car2 Products(2)

mRNA	Protein	Name
NM_009801.5	NP_033931.4	carbonic anhydrase 2
NM_001357334.1	NP_001344263.1	carbonic anhydrase 2

Car2 Protein Structure

alpha_CA

0
100
200
260 a.a.

Protein Preferred Names

Protein Names

carbonic anhydrase 2

carbonate dehydratase II

carbonic anhydrase II

Recombinant Car2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72861	Carbonic Anhydrase 2 Protein, Mouse (His)	AAH55291 (S2-K260)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01909	Car2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01910	Car2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01934	CARS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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