1. Gene
  2. Cav1 - caveolin 1, caveolae protein Gene

Cav1 - caveolin 1, caveolae protein Gene

Mus musculus

Also known as Cav; Cav-1

Gene ID: 12389 | Gene type: protein coding

About Cav1

Summary

Enables several functions, including Enzyme binding activity; identical protein binding activity; and protein heterodimerization activity. Involved in several processes, including negative regulation of programmed cell death; negative regulation of protein modification process; and regulation of gene expression. Acts upstream of with a negative effect on lactation. Acts upstream of or within several processes, including blood vessel diameter maintenance; blood vessel morphogenesis; and negative regulation of signal transduction. Located in several cellular components, including acrosomal membrane; caveola; and perinuclear region of cytoplasm. Is integral component of plasma membrane. Part of caveolar macromolecular signaling complex. Colocalizes with focal adhesion. Is expressed in several structures, including cardiovascular system; cerebral cortex; intestine smooth muscle circular layer; lung; and paraxial mesenchyme. Used to study Alzheimer's disease; breast cancer; and hypertrophic cardiomyopathy. Human ortholog(s) of this gene implicated in several diseases, including breast Cancer (multiple); lipodystrophy (multiple); primary open angle glaucoma; primary pulmonary hypertension; and systemic scleroderma (multiple). Orthologous to human CAV1 (caveolin 1). [provided by Alliance of Genome Resources, Apr 2022]

Cav1 Products(14)

mRNA Protein Name
NM_001243064.2 NP_001229993.1 caveolin-1 isoform 2
NM_001409558.1 NP_001396487.1 caveolin-1 isoform 1
NM_001409559.1 NP_001396488.1 caveolin-1 isoform 2
NM_001409560.1 NP_001396489.1 caveolin-1 isoform 2
NM_001409561.1 NP_001396490.1 caveolin-1 isoform 2
NM_001409562.1 NP_001396491.1 caveolin-1 isoform 2
NM_001409563.1 NP_001396492.1 caveolin-1 isoform 2
NM_001409564.1 NP_001396493.1 caveolin-1 isoform 3
NM_001409565.1 NP_001396494.1 caveolin-1 isoform 4
NM_001409566.1 NP_001396495.1 caveolin-1 isoform 5
NM_001409567.1 NP_001396496.1 caveolin-1 isoform 5
NM_001409568.1 NP_001396497.1 caveolin-1 isoform 6
NM_001409569.1 NP_001396498.1 caveolin-1 isoform 6
NM_007616.5 NP_031642.1 caveolin-1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
8552590 MGI
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
25017399 MGI
enables nitric-oxide synthase binding IPI
IPI: Inferred from physical interaction
25017399 MGI
enables oxysterol binding IMP
IMP: Inferred from mutant phenotype
34799735 MGI
enables peptidase activator activity IMP
IMP: Inferred from mutant phenotype
17349656 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11956154 MGI
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
9361015 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
25017399 MGI
enables protein tyrosine kinase inhibitor activity IMP
IMP: Inferred from mutant phenotype
25017399 MGI
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
25017399 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of MAPK cascade IMP
IMP: Inferred from mutant phenotype
12388746 MGI
acts upstream of or within angiogenesis IGI
IGI: Inferred from genetic interaction
12759260 MGI
involved in angiotensin-activated signaling pathway IGI
IGI: Inferred from genetic interaction
25017399 MGI
acts upstream of or within basement membrane organization IMP
IMP: Inferred from mutant phenotype
11884617 MGI
acts upstream of or within calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
12651616 MGI
acts upstream of or within calcium ion transport IMP
IMP: Inferred from mutant phenotype
17416589 MGI
acts upstream of or within caveola assembly IDA
IDA: Inferred from direct assay
11884617 MGI
involved in caveola assembly IGI
IGI: Inferred from genetic interaction
25006397 MGI
acts upstream of or within caveola assembly IMP
IMP: Inferred from mutant phenotype
12759260 MGI
acts upstream of or within caveolin-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
17715130 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
12388077 MGI
involved in cellular response to peptide hormone stimulus IGI
IGI: Inferred from genetic interaction
25017399 MGI
acts upstream of or within cellular response to transforming growth factor beta stimulus IMP
IMP: Inferred from mutant phenotype
21829547 MGI
acts upstream of or within cholesterol homeostasis IMP
IMP: Inferred from mutant phenotype
16603689 MGI
acts upstream of cytokine-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
12388746 MGI
acts upstream of endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
11884617 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
17416589 MGI
acts upstream of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
12388077 MGI
acts upstream of glandular epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
12388746 MGI
involved in insulin receptor internalization IMP
IMP: Inferred from mutant phenotype
27110488 MGI
acts upstream of or within intracellular calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
17098833 MGI
acts upstream of or within intracellular nitric oxide homeostasis IMP
IMP: Inferred from mutant phenotype
12177436 MGI
acts upstream of negative effect lactation IMP
IMP: Inferred from mutant phenotype
12388746 MGI
acts upstream of or within lipid storage IMP
IMP: Inferred from mutant phenotype
11884617 MGI
acts upstream of or within mammary gland development IMP
IMP: Inferred from mutant phenotype
12388746 MGI
acts upstream of or within mammary gland involution IMP
IMP: Inferred from mutant phenotype
12388746 MGI
acts upstream of or within membrane depolarization IMP
IMP: Inferred from mutant phenotype
17098833 MGI
acts upstream of or within muscle cell cellular homeostasis IMP
IMP: Inferred from mutant phenotype
17098833 MGI
acts upstream of or within negative regulation of MAP kinase activity IMP
IMP: Inferred from mutant phenotype
12388746 MGI
acts upstream of or within negative regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
12388077 MGI
involved in negative regulation of anoikis IMP
IMP: Inferred from mutant phenotype
22277751 MGI
involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
10816572 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17202321 MGI
acts upstream of or within negative regulation of cytokine-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
12388746 MGI
acts upstream of or within negative regulation of endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
11884617 MGI
acts upstream of or within negative regulation of epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
12388746 MGI
acts upstream of or within negative regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
12388077 MGI
involved in negative regulation of necroptotic process IMP
IMP: Inferred from mutant phenotype
23049990 MGI
acts upstream of or within negative regulation of nitric oxide biosynthetic process IMP
IMP: Inferred from mutant phenotype
12388077 MGI
acts upstream of or within negative regulation of nitric-oxide synthase activity IMP
IMP: Inferred from mutant phenotype
16380094 MGI
involved in negative regulation of protein ubiquitination IMP
IMP: Inferred from mutant phenotype
22277751 MGI
acts upstream of or within negative regulation of receptor signaling pathway via JAK-STAT IDA
IDA: Inferred from direct assay
12388746 MGI
acts upstream of or within negative regulation of receptor signaling pathway via JAK-STAT IGI
IGI: Inferred from genetic interaction
12388746 MGI
acts upstream of or within negative regulation of receptor signaling pathway via JAK-STAT IMP
IMP: Inferred from mutant phenotype
12388746 MGI
acts upstream of or within negative regulation of signal transduction IDA
IDA: Inferred from direct assay
9685399 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10816572 MGI
acts upstream of or within negative regulation of tyrosine phosphorylation of STAT protein IDA
IDA: Inferred from direct assay
12388746 MGI
acts upstream of or within negative regulation of tyrosine phosphorylation of STAT protein IMP
IMP: Inferred from mutant phenotype
12388746 MGI
acts upstream of nitric oxide biosynthetic process IMP
IMP: Inferred from mutant phenotype
12388077 MGI
involved in positive regulation of calcium ion transport into cytosol IDA
IDA: Inferred from direct assay
19052258 MGI
acts upstream of or within positive regulation of catalytic activity IMP
IMP: Inferred from mutant phenotype
17349656 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
15734843 MGI
involved in positive regulation of gap junction assembly IMP
IMP: Inferred from mutant phenotype
25017399 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
25017399 MGI
acts upstream of or within positive regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
11884617 MGI
involved in post-transcriptional regulation of gene expression IMP
IMP: Inferred from mutant phenotype
25017399 MGI
acts upstream of or within protein localization IMP
IMP: Inferred from mutant phenotype
17416589 MGI
acts upstream of or within protein transport IMP
IMP: Inferred from mutant phenotype
17715130 MGI
involved in regulation of cell communication by electrical coupling involved in cardiac conduction IMP
IMP: Inferred from mutant phenotype
25017399 MGI
acts upstream of or within regulation of fatty acid metabolic process IMP
IMP: Inferred from mutant phenotype
11884617 MGI
involved in regulation of heart rate by cardiac conduction IMP
IMP: Inferred from mutant phenotype
25017399 MGI
acts upstream of or within regulation of peptidase activity IMP
IMP: Inferred from mutant phenotype
17349656 MGI
acts upstream of or within regulation of smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
16782699 MGI
acts upstream of or within regulation of the force of heart contraction IMP
IMP: Inferred from mutant phenotype
16380094 MGI
acts upstream of or within regulation of the force of heart contraction by chemical signal IGI
IGI: Inferred from genetic interaction
18951881 MGI
involved in regulation of ventricular cardiac muscle cell action potential IMP
IMP: Inferred from mutant phenotype
25017399 MGI
involved in response to calcium ion IDA
IDA: Inferred from direct assay
19052258 MGI
acts upstream of or within response to estrogen IDA
IDA: Inferred from direct assay
12388746 MGI
acts upstream of or within response to hypoxia IMP
IMP: Inferred from mutant phenotype
16601228 MGI
acts upstream of or within response to ischemia IMP
IMP: Inferred from mutant phenotype
17293479 MGI
acts upstream of or within skeletal muscle tissue development IMP
IMP: Inferred from mutant phenotype
17200204 MGI
acts upstream of or within triglyceride metabolic process IMP
IMP: Inferred from mutant phenotype
11884617 MGI
acts upstream of tyrosine phosphorylation of STAT protein IMP
IMP: Inferred from mutant phenotype
12388746 MGI
acts upstream of or within vasculogenesis IMP
IMP: Inferred from mutant phenotype
16601228 MGI
acts upstream of or within vasoconstriction IMP
IMP: Inferred from mutant phenotype
17098833 MGI
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
10787428 MGI
located in acrosomal membrane IDA
IDA: Inferred from direct assay
11784086 MGI
located in caveola IDA
IDA: Inferred from direct assay
8552590 MGI
part of caveolar macromolecular signaling complex IDA
IDA: Inferred from direct assay
11884617 MGI
located in cell cortex IDA
IDA: Inferred from direct assay
10631317 MGI
located in cilium IDA
IDA: Inferred from direct assay
11784086 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
10787428 MGI
colocalizes with focal adhesion IDA
IDA: Inferred from direct assay
12091389 MGI
located in membrane IDA
IDA: Inferred from direct assay
10460238 MGI
located in membrane raft IDA
IDA: Inferred from direct assay
10197531 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
8552590 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
8552590 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
25017399 MGI
part of protein-containing complex IPI
IPI: Inferred from physical interaction
17416589 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

caveolin-1

caveolin, caveolae protein 1

caveolin, caveolae protein, 22 kDa

Cav1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross
Cav1 P49817 MCL1 Homo sapiens Q07820
Anti Bait CoIP
22277751
Cross
Cav1 P49817 MCL1 Homo sapiens Q07820
Confocal
22277751
Cross
Cav1 P49817 SCP2 Homo sapiens P22307
Anti Bait CoIP
15182174
Cross
Cav1 P49817 SCP2 Homo sapiens P22307
EM
15182174
Cross: Cross-species interaction Intra: Intraspecies interaction

Orthologs Information

Species Symbol Source ID
Homo sapiens Cav1 NCBI NCBI:857